ASCL1 Activates Neuronal Stem Cell-Like Lineage Programming through Remodeling of the Chromatin Landscape in Prostate Cancer

Scientists provided insights into the epigenetic alterations induced by androgen receptor pathway inhibitors (ARPIs), governed by ASCL1, provided a proof of principle of targeting ASCL1 to reverse neuroendocrine phenotype, supported luminal conversion and re-addiction to ARPIs.