Targeting CDCP1 Gene Transcription Coactivated by BRD4 and CBP/p300 in Castration-Resistant Prostate Cancer

Combined knockdown or dual-inhibition of BRD4 and CBP/p300 down-regulated CUB domain-containing protein 1 (CDCP1) transcription and downstream PI3K/AKT and/or SRC/MAPK signaling pathways in CRPC cells much more so than single-protein perturbation.