A Novel Survivin Dimerization Inhibitor without a Labile Hydrazone Linker Induces Spontaneous Apoptosis and Synergizes with Docetaxel in Prostate Cancer Cells

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The authors showed that the combination of tetracyclic aromatic core and docetaxel have strong synergism in inhibiting prostate cancer cell survival.
[Bioorganic & Medicinal Chemistry]
AbstractGraphical Abstract