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Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Scalable Production of Human Cortical Organoids Using a Biocompatible Polymer
[Nature Biomedical Engineering] The authors developed a scalable cerebral cortical organoid platform by screening biocompatible polymers that prevent the fusion of organoids cultured in suspension.
Applications of Human Lung Organoids to Human Respiratory Virus Research: Advances, Limitations, and Future Directions
[Infection] Investigators compare common research models for human respiratory viruses (HRVs), outline the establishment of human lung organoids, and explore their applications in HRV studies.
Self-organization of sinusoidal vessels in pluripotent stem cell-derived human liver bud organoids
[Nature Biomedical Engineering] The authors directly differentiated hPSCs into CD32b+ putative liver sinusoidal progenitors by dictating developmental pathways.
Maturation of Human Cardiac Organoids Enables Complex Disease Modeling and Drug Discovery
[Nature Cardiovascular Research] Researchers mimicked human heart maturation pathways in the setting of hPSC-derived cardiac organoids.
Engrafted Nitrergic Neurons Derived from hPSCs Improve Gut Dysmotility in Mice
[Nature] Scientists introduced a platform based on hPSCs for therapeutic development targeting gastrointestinal motility disorders.
Graft-Derived Horizontal Cells Contribute to Host-Graft Synapses in Degenerated Retinas after Retinal Organoid Transplantation
[Stem Cell Reports] Scientists used horizontal cell (HC)-depleted retinal degeneration mice and Islet1−/− genome-edited retinal organoids that contain HCs but not rod bipolar cells.
An Organ-Chip Model of Sporadic ALS Using iPSC-Derived Spinal Cord Motor Neurons and an Integrated Blood-Brain-Like Barrier
[Cell Stem Cell] The authors combined motor neurons from patients with early-onset disease with brain microvascular endothelial-like cells in a microfluidic device and added media flow, which enhances neuronal maturation and improved cellular health.
In Vitro Generation of a Ureteral Organoid from Pluripotent Stem Cells
[Nature Communications] By mimicking the in vivo developmental process of ureteral stromal progenitors (SPs) from the posterior intermediate mesoderm, investigators report in vitro induction protocols for ureteral SPs from mouse and human PSCs.
Lysophosphatidic Acid and Sphingosine-1-Phosphate Are Apical Polarity Cues in Multiple Organoid Systems
[Cell Reports] Exposing brain organoids to serum induces apical-out orientation. Lysophosphatidic acid, present in the medium of prior apical-out techniques, was identified as the causative factor.
APOE4 Impacts Cortical Neurodevelopment and Alters Network Formation in Human Brain Organoids
[Stem Cell Reports] The authors used hiPSC-derived cortical and ganglionic eminence organoids to examine APOE4’s influence during the development of cortical excitatory and inhibitory neurons.
Cholinergic Neuron-to-Glioblastoma Synapses in a Human iPSC-Derived Co-Culture Model
[Stem Cell Reports] Investigators reported a co-culture system employing patient-derived glioblastoma organoids and hiPSC-derived cholinergic neurons.
3D Quantification of Viral Transduction Efficiency in Living Human Retinal Organoids
[Small Methods] Readout on a single-cell level can be realized via fluorescence-based flow cytometry at the cost of tissue dissociation and loss of spatial information.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
