Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

Parechovirus Infection in Human Brain Organoids: Host Innate Inflammatory Response and Not Neuro-Infectivity Correlates to Neurologic Disease

[Nature Communications] Researchers expanded their current understanding of these differences in parechovirus A3 (PeV-A) central nervous system (CNS) disease using human brain organoids and clinical isolates of the two PeV-A genotypes. Their data indicated that PeV-A1 and A3 specific differences in neurological disease are not due to infectivity of CNS cells as both viruses productively infect brain organoids with a similar cell tropism.

Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients

[International Journal Of Cancer] Scientists established 75 patient-derived breast cancer organoid models. The results of H&E staining, immunohistochemical, and whole-exome sequencing revealed that patient-derived organoids inherited the histologic and genetic characteristics of their parental tumor tissues.

Parenteral Nutrition Emulsion Inhibits CYP3A4 in an iPSC Derived Liver Organoids Testing Platform

[Journal Of Pediatric Gastroenterology And Nutrition] Investigators exploited induced pluripotent stem cell derived liver organoids to provide a testing platform for parenteral nutriion associated liver disease. Liver organoids mimic the developing liver and contain the different hepatic cell types.

Expression of HIF1α in Intestinal Epithelium Restricts Arthritis Inflammation by Inhibiting RIPK3-Induced Cell Death Machinery

[Annals Of The Rheumatic Diseases] Researchers investigated the mechanism by which intestinal epithelial cell death induced arthritis. Effects of hypoxia-inducible factor 1α (HIF1α) stabilization by inhibition of prolyl hydroxylase domain-containing enzymes and treatment with the inhibitor of receptor-interacting protein kinase-3 (RIPK3) were tested in intestinal organoids and in collagen-induced arthritis.

Notoginsenoside R1 Promotes Lgr5+ Stem Cell and Epithelium Renovation in Colitis Mice via Activating Wnt/β-Catenin Signaling

[Acta Pharmacologica Sinica] The authors investigated the reparative effects of notoginsenoside R1 (NGR1) on mucosal barrier damage after the acute injury stage of DSS exposure. NGR1 (100 μM) also increased Lgr5+ cells and budding rates in a 3D intestinal organoid model. They demonstrated that NGR1 promoted intestinal stem cell proliferation and differentiation through activation of the Wnt signaling pathway.

A Compound That Inhibits Glycolysis in Prostate Cancer Controls Growth of Advanced Prostate Cancer

[Molecular Cancer Therapeutics] Scientists reported the preclinical activity, safety, and pharmacokinetics of a novel small molecule preclinical candidate, BKIDC-1553, with antiglycolytic activity. A human PDX model implanted in mice and a human organoid was studied for sensitivity to our BKIDC preclinical candidate.

Deciphering Fibroblast-Induced Drug Resistance in Non-Small Cell Lung Carcinoma Through Patient-Derived Organoids in Agarose Microwells

[Lab On A Chip] Investigators introduced an agarose microwell platform designed for patient-derived organoid-based tumor and tumor microenvironment models, enabling rapid drug screening and resistance studies with small sample volumes.

Molecular Insights of Cholestasis in MDR2 Knockout Murine Liver Organoids

[Journal Of Proteome Research] Hepatocyte-like organoids from multidrug resistance 2 (MDR2)-deficient mice (MDR2KO) were used to study the molecular alterations caused by the deficiency of this transporter. Proteomic analysis by mass spectrometry allowed the characterization of 279 proteins that were differentially expressed in MDR2KO compared with wild-type organoids.

Organoid-Based Personalized Medicine: From Tumor Outcome Prediction to Autologous Transplantation

[Stem Cells] The authors focus on the recent progress concerning the use of patient-derived organoids in personalized medicine, including diagnostics and disease prognosis, treatment outcome prediction to guide therapeutic advice, and organoid transplantation or cell-based therapies.

Vidac Pharma Receives Japanese Patent Office Notice of Allowance for VDA-1275 Cancer Drug Candidate

[Vidac Pharma Holdings, Plc. (Globe Newswire)] Vidac Pharma Holdings Plc. announced it has received a Notice of Allowance from the Japanese Patent Office for the composition and methods of use for its VDA-1275 drug candidate, which has shown multiple promising effects in preclinical studies. This new molecule shown effects through powerful synergistic effects in combination with two widely used types of chemotherapy in human liver organoids

Organ-on-Chip Models for Infectious Disease Research

[Nature Microbiology] The authors review various organ-on-chip models and how they have been applied for infectious disease research. They outline the properties that make them valuable tools in microbiology, such as dynamic microenvironments, vascularization, near-physiological tissue constitutions and partial integration of functional immune cells, as well as their limitations.

The Porcine Islet-Derived Organoid Showed the Characteristics As Pancreatic Duct

Researchers elucidated the characteristics of porcine islet organoids derived from porcine islets as a cell source for transplantation. Isolated porcine islets were 3D-cultured using...

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.

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