[NPJ Regenerative Medicine] Researchers evaluated ferrets exposed to a single dose of bleomycin longitudinally, and found sustained restrictive physiology, increased opacification and fibrotic injury in the lungs through 22 weeks.

[Scientific Reports] The authors investigated the roles of the transcription factor CEBPA and the sirtuin family protein SIRT4 in sepsis-induced acute lung injury through both cell-based experiments and animal models.

[npj Precision Oncology] Investigators reported that the epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) resistance mechanism is mediated by lysosome-related regulation.

[Cell Reports] Researchers demonstrated that genetic loss of protein kinase Cι alters the trajectory of mouse Kras/Trp53-driven lung adenocarcinoma tumors from one resembling lung development to one mimicking lung regeneration.

[Science Signaling] The authors found that inhibiting the proximal receptor tyrosine kinase signaling intermediate SOS1 promoted continued osimertinib efficacy in sensitive cells and restored sensitivity in cells with acquired resistance.

[Communications Biology] Researchers identified that tensin-1 (TNS1) is upregulated in a TGFβ-induced epithelial-mesenchymal transition cell model.

[Cancer Gene Therapy] Investigators reconstructed the epithelial-to-mesenchymal transition (EMT) spectrum in lung adenocarcinoma by integrating single-cell RNA sequencing data with advanced cell trajectory inference techniques.

[Cell Biology International] The authors summarize and compare previous studies of the application and complementarity of organ-chip technologies and traditional animal models for investigating the same genetic alterations.

[Broad Institute] The US FDA has approved sevabertinib, which was developed by Bayer Healthcare Pharmaceuticals in close collaboration with the Broad, and is the first FDA-approved medicine from the long-standing Broad-Bayer oncology research alliance.

[Advanced Science] A bioorthogonal crosslinking strategy using rhodamine and polyethylene glycol was reported to fabricate dense, mechanically reinforced collagen hydrogels.

[Journal of Biomedical Science] Scientists found that TGF-β1 induced mouse kidney progenitor cell differentiation into myofibroblasts on stiff matrices or endothelial-like cells on soft matrices. Matrix stiffness regulated PSPC1 and Neat1 to trigger either TGF-β1-induced transdifferentiation into myofibroblasts or angiogenesis on soft collagen gels.

[Advanced Healthcare Materials] Clinical use of current decellularized tissue (dECM) biomaterials, advances in the fabrication of dECM biomaterials, and hurdles to clinical translation of dECM products are discussed.