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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Apolipoprotein a-I: A Non-Negligible Marker in Hypertriglyceridemia-Induced Acute Pancreatitis
[European Journal of Medical Research] Investigators evaluated the correlation between apolipoprotein A-I levels and disease severity, progression, and clinical outcomes in hypertriglyceridemia-induced acute pancreatitis patients.
Mechanistic Investigation of FBXW11-Mediated Ubiquitination and Degradation of HIC1 in Regulating IRF1 Transcription and Accelerating Acute Pancreatitis Progression
[Digestive Diseases and Sciences] Scientists elucidated the molecular mechanism by which F-box and WD repeat domain-containing 11 (FBXW11) promotes the progression of acute pancreatitis through ubiquitination-mediated degradation of hypermethylated in cancer 1 (HIC1), thereby enhancing interferon regulatory factor 1 (IRF1) transcription.
Targeting TNK2/ACK1 Reverses the Immunosuppressive Tumor Microenvironment and Synergizes with Immunochemotherapy in Pancreatic Cancer
[Nature Communications] Researchers identified TNK2/ACK1 as a key regulator of the immunosuppressive tumor microenvironment in pancreatic ductal adenocarcinoma (PDAC). TNK2/ACK1 is significantly upregulated in PDAC, at least in part via gene amplification and KRAS-G12 mutations.
AGR2 Suppresses Ferroptosis via the P53/FPN1 Regulatory Axis and Drives Therapeutic Vulnerabilities in Pancreatic Cancer
[Cell Death & Disease] Scientists showed the critical role of AGR2 in ferroptosis suppression across pancreatic cancer cell lines and in vivo models.
Efficacy and Safety of Garsorasib in Patients with KRAS G12C-Mutated Advanced Pancreatic Cancer
[British Journal of Cancer] Garsorasib demonstrated encouraging antitumor activity and a tolerable safety profile in patients with KRAS G12C-mutated advanced pancreatic cancer.
RNF187 Neddylation in Pancreatic Cancer Activates Malignancy via IQGAP1-Dependent Actin Cytoskeleton Rearrangement
[Oncogene] Investigators focused on screening neddylation-related molecules in pancreatic cancer (PC) and identified RNF187 as a key player, demonstrating its overexpression in PC and its ability to enhance cell proliferation and invasion both in vitro and in vivo.
A Mitochondria-Related Gene-Based Signature Predicts Pancreatic Ductal Adenocarcinoma Clinical Outcome and Revealed CAMK2A/THEM4 Regulates Progression Phenotypes and Mitophagy In Vivo and In Vitro
[Journal of Translational Medicine] Researchers established a mitochondria-driven prognostic model for pancreatic ductal adenocarcinoma (PDAC) and identified the CAMK2A-THEM4-AKT axis as a novel therapeutic target.
DTL Promotes Pancreatic Cancer Progression through Ubiquitin-Mediated Degradation of SMAD4
[International Journal of Biological Macromolecules] Scientists identified the DTL-SMAD4-Wnt/β-catenin axis as a pivotal signaling cascade and underscore the potential of DTL as a therapeutic target in the context of pancreatic cancer.
New Implications from Long-Term Outcomes of Perioperative Therapy in Resectable Pancreatic Cancer
[British Journal of Cancer] The results of long-term follow-up studies of the adjuvant PRODIGE24 trial comparing FOLFIRINOX with gemcitabine and the ESPAC4 trial of gemcitabine-capecitabine versus gemcitabine have consolidated and expanded the applicability of adjuvant chemotherapy.
YD Bio Limited Expands OkaiDxâ„¢ Testing Portfolio to Pancreatic and Colorectal Cancer Detection Across the US and Provides Clinical Research Update on Pancreatic Cancer...
[YD Bio Limited] YD Bio Limited provided an update regarding US access to the OkaiDx™ platform for post‑treatment breast cancer monitoring, detailing the continued expansion of OkaiDx™ blood‑based testing platform to pancreatic and colorectal cancer detections while presenting new clinical advances in early pancreatic cancer detection.
Directly Reprogrammed NK Cells Driven by BCL11B Depletion Enhance Targeted Immunotherapy against Pancreatic Ductal Adenocarcinoma
[Journal of Hematology & Oncology] Scientists presented a synergistic immunotherapy platform that integrates natural killer reprogramming, CAR engineering, and tumor sensitization. The combinatorial approach significantly enhances antitumor efficacy in PDAC and offers a promising strategy for overcoming immune resistance in solid tumors.
Injectable Self-Healing Hydrogels Loaded with Islet-Integrated Microfiber Scaffolds for Islet Transplantation in Diabetes Mellitus
[Science Bulletin] Inspired by the extracellular matrix structure of the pancreatic islets, an injectable self-healing hydrogel loaded with islet-integrated microfiber scaffolds was constructed for islet transplantation.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
