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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
NAC and DNase I Synergistically Reduce NETs to Attenuate Severe Acute Pancreatitis via Suppressing the NETs/NF-κB/CXCL3 Pathway
[Apoptosis] Researchers investigated whether combined N-acetylcysteine (NAC) and deoxyribonuclease I (DNase I) therapy mitigates severe acute pancreatitis and associated lung injury by suppressing neutrophil extracellular traps (NETs) formation and degradation, respectively, and explores the underlying molecular mechanisms.
Evaluation of Rat Pancreatic Islets Damage after siRNA Microporation
[PLOS One] The authors evaluated whether microporation is a suitable technique for the transfection of pancreatic islets and whether the selected siRNA is recognized by islet cells as foreign, potentially triggering an inflammatory or cytotoxic response.
Glycolytic Heterogeneity Drives Metabolic-Targeted Therapy in Pancreatic Ductal Adenocarcinoma
[Signal transduction and targeted therapy] Scientists investigated whether glycolytic activity follows a consistent expression pattern across pancreatic ductal adenocarcinoma patients and explored how metabolic diversity influences therapeutic responses.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression
[Cancer Research] The authors investigated the contribution of WT1+ mesenchymal cells to cancer-associated fibroblasts populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer.
FNDC4 Drives Metastasis and Immune Evasion in Pancreatic Cancer
[Cancer Research] Investigators found that fibronectin type III domain–containing 4 (FNDC4), known for its role in macrophage polarization and metabolic regulation, was elevated in metastatic PDAC cells and correlated with poor patient outcomes.
Selective Targeting of NRF2-High Pancreatic Ductal Adenocarcinoma with an NQO1-Activatable Prodrug
[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that NRF2high PDAC can be selectively controlled by a prodrug, C29h, that is specifically activated by the NRF2-inducible enzyme NAD(P)H:quinone oxidoreductase-1 (NQO1).
Identification and Characterization of MARCO-Expressing Tumor-Associated Macrophages in Pancreatic Ductal Adenocarcinoma with Pan-Cancer Relevance
[NPJ Precision Oncology] Researchers identified a subset of macrophage receptor with collagenous structure (MARCO)-expressing macrophages with strong immunosuppressive signatures that were markedly increased in PDAC patients.
CKAAKN Peptide-Conjugated Long-Circulating Nanoliposomes for the Targeted Delivery of Oridonin to Pancreatic Cancers
[Scientific Reports] Investigators developed a long-circulating PEGylated nanoliposome (ORI@PD-Lipo) with 1,2-distearoylphosphoethanolamine- polyethyleneglycol-amine (DSPE-PEG2000-NH2) to deliver oridonin, one of the active ingredients in Rabdosia rubescens in this study.
Immunometabolic Reprogramming and β-cell Dedifferentiation: Integrated Mechanisms Driving Type 2 Diabetes Progression
[Diabetes Research and Clinical Practice] The authors synthesize current evidence to illustrate how metabolic and immune pathways converge on key molecular regulators of β-cell fate.
Diabetes Canada Awards Nearly $6 Million in Funding to New Research Projects
[Diabetes Canada] Diabetes Canada announced the winners of its End Diabetes Awards, an annual competition that aims to improve the lives of people living with, or at risk of, diabetes through innovative research. 13 new research projects will receive a 3-year grant of up to $450,000 each—for a total of almost $6 million.
Wilms Tumor 1-Expressing Stromal Cells Promote Pancreatic Cancer Progression
[Cancer Research] Scientists investigated the contribution of WT1+ mesenchymal cells to cancer-associated fibroblast populations and evaluated the functional role of WT1+ stromal cells in pancreatic cancer.
Physical Differentiation of Adipose-Derived Mesenchymal Stem Cells Into Pancreatic Beta-Like Cells Using Cell-Imprinting and Evaluation of Insulin Production
[Adipocyte] Researchers physically induced the differentiation of rat adipose-derived mesenchymal stem cells into β-like cells using the cell-imprinting technique.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
