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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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Directly Reprogrammed NK Cells Driven by BCL11B Depletion Enhance Targeted Immunotherapy against Pancreatic Ductal Adenocarcinoma
[Journal of Hematology & Oncology] Scientists presented a synergistic immunotherapy platform that integrates natural killer reprogramming, CAR engineering, and tumor sensitization. The combinatorial approach significantly enhances antitumor efficacy in PDAC and offers a promising strategy for overcoming immune resistance in solid tumors.
Injectable Self-Healing Hydrogels Loaded with Islet-Integrated Microfiber Scaffolds for Islet Transplantation in Diabetes Mellitus
[Science Bulletin] Inspired by the extracellular matrix structure of the pancreatic islets, an injectable self-healing hydrogel loaded with islet-integrated microfiber scaffolds was constructed for islet transplantation.
Fructose and Follistatin Potentiate Acute MASLD during Complete Hepatic Insulin Resistance
[Nature Communications] Investigators found that male LDKO mice lacking hepatic insulin receptor substrates acutely developed metabolic-associated steatotic liver disease if fed a fructose-enriched “steatohepatitis diet” or high-fructose diet.
CARD9 Conveys Pancreatic Islet Sympathetic Nervous β2 Signals to Reshape Macrophage Creatine Metabolism in Type 1 Diabetes
[Advanced Science] Single-cell omics and whole-tissue immunostaining revealed a decrease in pancreatic sympathetic nerve density in type 1 diabetes (T1D) patients and T1D mouse models.
CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer
[Cancer Research] To further determine genetic mechanisms of KRAS inhibitor (KRASi) resistance, scientists performed KRASi-anchored CRISPR-Cas9 loss-of-function screens in KRASG12D, KRASG12C, KRASG12R, and KRASQ61H mutant PDAC cell lines, using six KRASi, to identify genes that modulate sensitivity to KRAS inhibition.
TRPV6-Related Pancreatitis: Natural History and the Impact of the Pancreas-Specific Deletion on Pancreatitis in Mice
[Journal of Gastroenterology] Functionally impaired TRPV6 variants significantly influenced the clinical outcomes of chronic pancreatitis. TRPV6 in pancreatic acinar cells might play a protective role against pancreatitis in mice.
Serum Levels of Trace Elements and Minerals in Non-Alcoholic Fatty Liver Disease Patients with and Without Type 2 Diabetes Are Associated with Metabolic Risk...
[Biological Trace Element Research] Investigators assessed serum levels of essential trace elements and minerals in non-alcoholic fatty liver disease patients with and without type 2 diabetes mellitus, as well as evaluate their association with metabolic risk biomarkers with adjustment for the prevalence of comorbidities.
Cannabidiol in Pancreatic Ductal Adenocarcinoma: Preclinical Evidence, Molecular Mechanisms, and Translational Challenges
[Cancer Cell International] The authors evaluate the preclinical and early clinical evidence regarding cannabidiol’s anticancer effects in PDAC, with emphasis on its molecular mechanisms, therapeutic synergies, and translational feasibility.
Oncolytics Biotech® Aligns with FDA on Pivotal Study Design for Pelareorep in First-Line Pancreatic Cancer
[Oncolytics Biotech®, Inc.] Oncolytics Biotech®, Inc. announced alignment with the US FDA regarding the design of its pivotal study of pelareorep in combination with standard-of-care therapy for the first-line treatment of metastatic pancreatic ductal adenocarcinoma.
m6a Modification-Mediated LINC01547 Promotes Pancreatic Cancer Growth and Gemcitabine Resistance through Mir-34a-5p/MYH9 Axis
[Biochemical Genetics] Researchers investigated the function of LINC01547 in PDAC progression and chemoresistance. LINC01547 was significantly upregulated in PDAC tissues and cell lines, and its high expression correlated with unfavorable patient outcomes.
Sodium Perborate Tetrahydrate Targets Pancreatic Cancer Cells by Inducing Apoptosis, Arresting the Cell Cycle, and Disrupting Cytoskeletal Integrity
[Molecular Biology Reports] Researchers investigated the anti-cancer potential of the boron-containing compound sodium perborate tetrahydrate in pancreatic cancer cell lines.
Adaptive Mechanisms in Pancreatic Islets Counteract Mitochondrial Dysfunction in Barth Syndrome
[Diabetologia] Scientists determined how Tafazzin deficiency affects mouse pancreatic islet metabolism and hormone secretion, and whether systemic signals, such as circulating factors, modulate these effects in vivo.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
