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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
The Efficiency of Stem Cell Differentiation into Functional Beta Cells for Treating Insulin-Requiring Diabetes: Recent Advances and Current Challenges
[Endocrine] The authors review the current advances and challenges faced by stem cell differentiation into functional β-cells for diabetes treatment.
E3 Ubiquitin Ligase UBR5 Promotes Gemcitabine Resistance in Pancreatic Cancer by Inducing O-GlcNAcylation-Mediated EMT via Destabilization of OGA
[Cell Death & Disease] Investigators reported that ubiquitin-protein ligase E3 module N-recognition 5 (UBR5) was a therapeutic target against gemcitabine (GEM) resistance. Further analysis revealed that UBR5 promoted GEM resistance in pancreatic cancer cells by enhancing O-GlcNAcylation-mediated epithelial-mesenchymal transition.
3D Printed VEGF-CPO Biomaterial Scaffold to Promote Subcutaneous Vascularization and Survival of Transplanted Islets for the Treatment of Diabetes
[International Journal Of Biological Macromolecules] Investigators utilized biocompatible copolymers of L-lactide and D,L-lactide to manufacture a biomaterial scaffold with a mesh-like structure via 3D printing technology, providing a material foundation for encapsulating pancreatic islet cells.
A Mucus Production Program Promotes Classical Pancreatic Ductal Adenocarcinoma
Investigators explored intratumour heterogeneity and plasticity of cancer cell states in pancreatic dutal adenocarcinoma (PDA) in order to reveal cell state-specific regulators. They analyzed...
MKLN1-AS Promotes Pancreatic Cancer Progression as a Crucial Downstream Mediator of HIF-1α through miR-185-5p/TEAD1 Pathway
[Cell Biology And Toxicology] The authors highlighted the important role played by the long noncoding RNA MKLN1-AS, which was controlled by hypoxia-inducible factor-1 alpha (HIF-1α), in the progression of PDAC.
P2X7R and P2X4R Expression of Mice Submandibular Gland in High-Fat Diet/Streptozotocin-Induced Type 2 Diabetes
[Scientific Reports] Researchers evaluated P2X7R and P2X4R expression and morphological changes in the submandibular gland in type 2 diabetes mellitus.
Bax Inhibitor-1 Preserves Pancreatic β-Cell Proteostasis by Limiting Proinsulin Misfolding and Programmed Cell Death
[Cell Death & Disease] Investigators uncovered a new role for bax inhibitor-one, a negative regulator of inositol-requiring enzyme 1 in preserving β-cell health against terminal unfolded protein response (UPR)-induced apoptosis and pyroptosis in the context of supraphysiological loads of insulin production.
The Janus Kinase 1 Is Critical for Pancreatic Cancer Initiation and Progression
[Cell Reports] Using a ligand-controlled and pancreas-specific knockout in adult mice, researchers demonstrated that Janus tyrosine kinase (JAK1) deficiency prevented the formation of KRASG12D-induced pancreatic tumors. They established that JAK1 was essential for the constitutive activation of STAT3, whose activation is a prominent characteristic of PDAC.
Oncolytics Biotech® Receives Regulatory Clearance to Evaluate Pelareorep in Combination with Modified FOLFIRINOX +/- an Anti-PD-L1 Inhibitor in Pancreatic Cancer
[Oncolytics Biotech, Inc.] Oncolytics Biotech® Inc. will commence enrollment into a new GOBLET study pancreatic cancer cohort following both German regulatory and ethics approvals. This cohort will evaluate pelareorep in combination with modified FOLFIRINOX with or without the PD-L1 immune checkpoint inhibitor atezolizumab in newly diagnosed patients with PDAC.
SUCNR1 Regulates Insulin Secretion and Glucose Elevates the Succinate Response in People with Prediabetes
[Journal Of Clinical Investigation] Scientists reported that the succinate receptor (SUCNR1) was expressed in β-cells and was up-regulated in hyperglycemic states in mice and humans.
Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
[Cancer Research] Researchers used a convergence approach to identify tumor cell and cancer-associated fibroblast interactions through the integration of single-cell data from human tumors with human organoid coculture experiments.
Positive Feedback Regulation between Glycolysis and Histone Lactylation Drives Oncogenesis in Pancreatic Ductal Adenocarcinoma
[Molecular Cancer] The participation of histone lactylation in the growth and progression of PDAC was confirmed through inhibition of histone lactylation by glycolysis inhibitors or lactate dehydrogenase A knockdown both in vitro and in vivo.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
