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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
Single-Cell Multiome and Spatial Profiling Reveals Pancreas Cell Type-Specific Gene Regulatory Programs of Type 1 Diabetes Progression
[Science Advances] Scientists performed single-nucleus multiomics and spatial transcriptomics in up to 32 nondiabetic, autoantibody-positive, and type 1 diabetes pancreas donors.
GPRC5B Preserves a Mature β-cell State in Obesity by Controlling MafA Expression
[JCI Insight] Using tamoxifen-inducible, β-cell-specific GPRC5B knockout mice, researchers showed that loss of GPRC5B does not affect β-cell function in the lean state, but results in strongly reduced insulin secretion and disturbed glucose tolerance in mice subjected to high fat diet for 16 weeks.
Nobiletin Alleviates Npy1r-Mediated Insulin Secretion Deficiency of Islet β-Cells via the Clock-Modulatory Signaling
[Molecular Nutrition & Food Research] Scientists investigated nobiletin's stimulatory effects on insulin secretion via neuropeptide Y1 receptor (Npy1r) and clock-modulatory signaling to elucidate its underlying mechanism.
Pancreatic Stellate Cells Promote Pancreatic Regeneration in Chronic Pancreatitis via Exosomal lncRNA MALAT1-Induced Acinar-Ductal Metaplasia
[Biochemical and Biophysical Research Communications] Investigators explored the impact of pancreatic stellate cells on pancreatic regeneration through exosome-mediated lncRNA MALAT1 in acinar-to-ductal metaplasia.
Durotaxis Is a Driver and Potential Therapeutic Target in Lung Fibrosis and Metastatic Pancreatic Cancer
[Nature Cell Biology] Researchers identified the focal adhesion kinase–paxillin interaction as a durotaxis-specific mechanosensory module and demonstrated that its genetic or pharmacological disruption reduces disease progression in mouse models of lung fibrosis and metastatic pancreatic cancer in vivo.
SLC7A11-AS1 Contributes to Prolonged Activation of Activin a/Smad Signaling by Suppressing PPM1A Myristoylation in Pancreatic Cancer
[British Journal of Cancer] SLC7A11-AS1 contributes to prolonged activation of activin A/Smad signaling by suppressing PPM1A myristoylation. Targeting both SLC7A11-AS1 and activin A may offer a potential therapeutic strategy for overcoming gemcitabine resistance in PDAC.
Bioactive Compounds from Marine Algae in Pancreatic Cancer Therapy: Mechanistic Insights Into Fucoidan and Phlorotannins: A Review
[Medical Oncology] The authors examine fucoidan, a sulfated polysaccharide, and phlorotannins, polyphenols exclusive to brown algae, emphasizing their therapeutic effects and molecular mechanisms in pancreatic cancer.
Rezolute Announces Alignment with FDA on Streamlined Design for Ongoing Phase 3 Trial of Ersodetug in Tumor Hyperinsulinism
[Rezolute, Inc.] Rezolute, Inc. announced that the Company has gained alignment with FDA on a significantly streamlined clinical development path for its ongoing Phase III study of ersodetug for the treatment of hypoglycemia caused by tumor hyperinsulinism.
TRAF3IP2-AS1 Deficiency Induces Necroptosis to Promote Pancreatic Cancer Liver Metastasis
[Cancer Research] Using patient-derived organoid models, single-cell RNA sequencing, and multiplex immunofluorescence staining of samples from patients with PDAC, in vivo TGFβ1 conditional knockout mouse models, and 3D in vitro models, scientists discovered that the formation of intratumoral necrotic foci in pancreatic cancer is closely associated with liver metastatic events.
An Allele-Agnostic Mutant-KRAS Inhibitor Suppresses Tumor Maintenance Signals and Reprograms Tumor Immunity in Pancreatic Cancer
[Science Translational Medicine] Researchers comprehensively evaluated the preclinical efficacy of BI-2493, a first-in-class allele-agnostic mutant-KRAS inhibitor, in PDAC.
PIM1 Protects Pancreatic Ductal Cancer Cells from Glucose Deprivation-Induced Oxidative Stress via OXR1 Phosphorylation
[Biochimica Et Biophysica Acta-Molecular Basis of Disease] Investigators found that PIM1, a serine/threonine kinase, is upregulated in PDAC tumors and serves as a poor prognostic indicator.
Aryl Hydrocarbon Receptor Ligands Drive Pancreatic Cancer Initiation and Progression through Pro-Tumorigenic T Cell Polarization
[Cancer Discovery] The authors showed that aryl hydrocarbon receptor ligands found in cigarette smoke, like the carcinogen 2,3,7,8-tetrachlorodibenzo-p-dioxin, promote pancreatic dysplasia and PDAC progression in a mouse model of this disease.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
