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Pancreatic Cell News is an online resource providing updates on the latest pancreatitis, diabetes, and pancreatic cancer research.
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m6a Modification-Mediated LINC01547 Promotes Pancreatic Cancer Growth and Gemcitabine Resistance through Mir-34a-5p/MYH9 Axis
[Biochemical Genetics] Researchers investigated the function of LINC01547 in PDAC progression and chemoresistance. LINC01547 was significantly upregulated in PDAC tissues and cell lines, and its high expression correlated with unfavorable patient outcomes.
Sodium Perborate Tetrahydrate Targets Pancreatic Cancer Cells by Inducing Apoptosis, Arresting the Cell Cycle, and Disrupting Cytoskeletal Integrity
[Molecular Biology Reports] Researchers investigated the anti-cancer potential of the boron-containing compound sodium perborate tetrahydrate in pancreatic cancer cell lines.
Adaptive Mechanisms in Pancreatic Islets Counteract Mitochondrial Dysfunction in Barth Syndrome
[Diabetologia] Scientists determined how Tafazzin deficiency affects mouse pancreatic islet metabolism and hormone secretion, and whether systemic signals, such as circulating factors, modulate these effects in vivo.
Impact of Exendin-4 on the Differentiation and Function of Transplanted Porcine Neonatal Pancreatic Cell Clusters in Diabetic Nude Mice
[Journal of Diabetes Research] Researchers investigated whether posttransplant treatment with exendin-4 could accelerate neonatal pancreatic cell clusters differentiation and improve long-term glycemic outcomes in diabetic nude mice.
SMUG1 Promoted the Progression of Pancreatic Cancer via AKT Signaling Pathway through Binding with FOXQ1
[Chinese Medical Journal] SMUG1 promoted proliferation, migration, gemcitabine resistance, and c-Myc protein stability in pancreatic cancer via protein kinase B signaling through binding with FOXQ1.
Oncogenic Peptide Encoded by Noncoding RNA of FOXM1 Promotes Pancreatic Cancer Malignancy through PI3K/AKT Signaling
[Molecular Carcinogenesis] Investigators determined the function and mechanism of FOXM1s-encoded peptide, FOXM1s, in the development and progression of pancreatic cancer.
The Association Between Serum HbA1c and Infected Pancreatic Necrosis in Acute Necrotizing Pancreatitis
[BMC Gastroenterology] Scientists explored the association between poor glycemic control and infected pancreatic necrosis in patients with acute necrotizing pancreatitis.
Diagnosis and Treatment Strategies for Hereditary Pancreatic Cancer Syndrome
[International Journal of Clinical Oncology] A germline pathogenic variant of BRCA suggests the effectiveness of platinum agents and PARP inhibitors against pancreatic cancers. The need for genetic counseling and testing is increasing to support at-risk individuals in making autonomous decisions based on sufficient information.
Revolution Medicines’ RAS(ON) Multi-Selective Inhibitor Daraxonrasib Granted US FDA Orphan Drug Designation in Pancreatic Cancer
[Revolution Medicines, Inc.] Revolution Medicines, Inc. announced that the US FDA has granted Orphan Drug Designation to daraxonrasib, the company’s RAS(ON) multi-selective inhibitor, for the treatment of pancreatic cancer.
Human Pancreatic α-Cell Heterogeneity and Trajectory Inference Analyses Reveal SMOC1 As a β-Cell Dedifferentiation Gene
[Nature Communications] Using single-cell and single-nucleus RNA-seq, RNA velocity, PAGA/cell trajectory inference, and gene commonality, scientists interrogated α-β-cell fate switching in human islets.
Functional Recovery of Islet β Cells in Human Type 2 Diabetes: Transcriptome Signatures Unveil Therapeutic Approaches
[Science Advances] Scientists studied islets from nondiabetic and type 2 diabetes (T2D) donors. They examined whether T2D β cell dysfunction can be rescued, charted the underlying molecular mechanisms by RNA sequencing, and mined transcriptomes for drug targets.
Truncated CD19 As a Selection Marker for the Isolation of Stem Cell Derived β-Cells
[Disease Models & Mechanisms] Investigators explored CD19 as a potential cell surface marker for the enrichment of insulin-expressing stem cell-derived β-cells.
Pancreatic Cell News highlights recent top articles in the field of pancreatic cell research. These articles have been carefully selected from high-impact, peer-reviewed academic journals by our experienced editorial team. We cover topics including pancreatic cell culture, pancreatitis, diabetes, and pancreatic cancer. We also feature the latest industry and policy news alongside job postings and upcoming events to keep scientists current while saving them valuable time.
