Prostate Cell News

Prostate Cell News is an online resource summarizing the latest prostate cell research.

The Role of RAS Oncogenes in Controlling Epithelial Mechanics

[Trends in Cell Biology] Investigators discuss the role of oncogenic RAS in controlling mechanical cell phenotypes, and how these mechanical changes promote oncogenic transformation in single cells and tissues.

90 New Grants To Outsmart Cancer, Totalling $10.8 Million

[Cancer Research Society] The Cancer Research Society is awarding 90 new research grants valued at $10.8 million as part of its annual competition. It is an all-time record for the organization for a second year in a row. The grants are awarded to some of the most promising cancer research projects in Canada.

Direct Cell–Cell Interaction Regulates Division of Stem Cells From PC-3 Human Prostate Cancer Cell Line

[Biochemical and Biophysical Research Communications] Investigators found that the proliferation of PC-3-derived CSCs was significantly decreased in the presence of non-CSC-rich parental PC-3 cells compared with that in a culture in which they were absent.

Functional Precision Cancer Medicine: Drug Sensitivity Screening Enabled by Cell Culture Models

[Trends in Pharmacological Sciences] The authors provide an overview of the current state of functional precision medicine, highlight advances for drug-sensitivity screening enabled by cell culture models, and discuss how artificial intelligence can be coupled to functional precision medicine to guide patient stratification.

CYCLIN K Down-Regulation Induces Androgen Receptor Gene Intronic Polyadenylation, Variant Expression and PARP Inhibitor Vulnerability in Castration-Resistant Prostate Cancer

[Proceedings of the National Academy of Sciences of the United States of America] The authors demonstrated that pharmacological inhibition or genetic inactivation of CDK12 induces androgen receptor (AR) gene intronic polyadenylation intronic polyadenylation usage, AR-variant expression, and prostate cancer cell resistance to the antiandrogen enzalutamide.

CCR3 Blockage Elicits Polyploidization Associated with the Signatures of Epithelial-Mesenchymal Transition in Carcinoma Cell Lines

[Cancer Gene Therapy] Researchers explored the blockage of chemokine receptor CCR3 in carcinoma cell lines and found that inhibition of CCR3 induced the formation of polyploid giant cells and stabilization of β-catenin via the PI3K/Akt/GSK-3β signaling pathway.

Transgenic Construction and Functional miRNA Analysis Identify the Role of miR-7 in Prostate Cancer Suppression

[Oncogene] The authors found that expression of miR-7, regulated by p53, was lower in prostate cancer tissues, and miR-7 overexpression significantly mitigated prostate cancer cells growth both in vitro, in organoids, and in vivo regardless of p53 status.

Transcriptional Profiling of Matched Patient Biopsies Clarifies Molecular Determinants of Enzalutamide-Induced Lineage Plasticity

[Nature Communications] To improve our understanding of enza resistance, the authors analyzed the transcriptomes of matched biopsies from men with metastatic CRPC obtained prior to treatment and at progression.

Functions and Underlying Mechanisms of lncRNA HOTAIR in Cancer Chemotherapy Resistance

[Cell Death Discovery] The authors review the mechanisms underlying HOTAIR-related drug resistance and discuss the limitations of current knowledge and propose potential future directions.

Design, Synthesis, and Biological Evaluation of Androgen Receptor Degrading and Antagonizing Bifunctional Steroidal Analogs for the Treatment of Advanced Prostate Cancer

[Journal of Medicinal Chemistry] In vitro, 67-b exhibited excellent antiproliferative activity and potent androgen receptor (AR) degradation activity in different PCa cells, as well as outstanding antagonistic activity against wild-type and mutant ARs.

Investigation of the Effect of Meclofenamic Acid on the Proteome of LNCaP Cells Reveals Changes in Alternative Polyadenylation and Splicing Machinery

[Medical Oncology] Meclofenamic acid, a non-steroidal anti-inflammatory drug, with anti-tumor effects in various types of cancers, was used to investigate its effects on LNCaP cells, a prostate cancer cell line, at the proteome level.

The Effect of Ciprofloxacin on Doxorubicin Cytotoxic Activity in the Acquired Resistance to Doxorubicin in DU145 Prostate Carcinoma Cells

[Medical Oncology] Scientists assessed the influence of ciprofloxacin against the doxorubicin-resistant androgen-independent prostate cancer DU145 cells.

Published since 2010, Prostate Cell News compiles top scientific journal articles covering the characterization, behavior, and culturing of prostate cells. Additionally, our editorial team curates the latest press releases, technical advances, jobs, and events relevant to the prostate cell research community. Prostate Cell News saves scientists valuable time while keeping them informed in their field, facilitating the rapid exchange of cutting edge research updates and science news.

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