Daiichi Sankyo and Gustave Roussy Enter Innovative Research Collaboration for DXd ADCs DS-1062 and Patritumab Deruxtecan

Daiichi Sankyo Company, Limited and Gustave Roussy announced a multi-year, multi-study research collaboration to enrich and further enable the development of DS-1062 and patritumab deruxtecan, two of Daiichi Sankyo’s lead DXd antibody drug conjugates, in lung and breast cancer.
[Daiichi-Sankyo]
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Spatial Density and Distribution of Tumor-Associated Macrophages Predict Survival in Non-Small-Cell Lung Carcinoma

Scientists investigated tumor-associated macrophage (TAM) subtype density and distribution between tumor center and invasive margin in human lung cancer and TAM associations with overall survival.
[Cancer Research]
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Cell–Cell Interaction Mechanisms in Acute Lung Injury

The authors provide an overview of current advancements in understanding the role of cell–cell interaction in the development of acute lung injury (ALI) and depict molecular mechanisms by which cell–cell interactions regulate lung inflammation, focusing on inter-cellular activities and signaling pathways that point to possible therapeutic opportunities for ALI/acute respiratory distress syndrome.
[Shock]
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Lantern Pharma Establishes Manufacturing Network in Preparation for Its Phase II Clinical Trial for the Treatment of Non-Small Cell Lung Cancer and a Phase I Clinical Trial for Solid Tumors and Glioblastoma

Lantern Pharma announced entering into agreements with leading contract manufacturing companies for process development and manufacturing for two of Lantern’s oncology drug candidates, LP-300 and LP-184.
[Lantern Pharma Inc.]
Press Release

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Emergence of a High-Plasticity Cell State during Lung Cancer Evolution

The authors profile single-cell transcriptomes of genetically engineered mouse lung tumors at seven stages, from pre-neoplastic hyperplasia to adenocarcinoma.
[Cancer Cell]
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Epigenomic State Transitions Characterize Tumor Progression in Mouse Lung Adenocarcinoma

Scientists used single-cell epigenomics to profile chromatin state transitions in a mouse model of lung adenocarcinoma. They identified an epigenomic continuum representing loss of cellular identity and progression toward a metastatic state.
[Cancer Cell]
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NRF2-GPX4/SOD2 Axis Imparts Resistance to EGFR-Tyrosine Kinase Inhibitors in Non-Small-Cell Lung Cancer Cells

The authors investigated the role of NRF2 in resistance to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). They showed that NRF2 protein levels were markedly increased in a panel of EGFR-TKI-resistant non-small cell lung cancer cell lines due to slow degradation of NRF2 protein.
[Acta Pharmacologica Sinica]
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Clinical Trials Rebound After COVID-19 Crash, but Can Enrollment Gains Continue?

For the hundreds of thousands of people enrolling in clinical trials every year—and for whom experimental therapies can offer a last hope—a new report provides some welcome news: Enrollment in clinical studies in the United States is on the rebound after disruptions caused by the COVID-19 pandemic.
[ScienceInsider]
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Science Money Slashed in EU’s €1.8-Trillion Budget Deal

A historic €1.8-trillion (US$2.1-trillion) budget deal reached by European Union (EU) leaders to fund its next seven years — and its recovery from the coronavirus pandemic — has left scientists and research advocates disappointed.
[Nature News]
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Characterization and Treatment of SARS-CoV-2 in Nasal and Bronchial Human Airway Epithelia

Researchers used reconstituted human airway epithelia to isolate and then characterized the viral infection kinetics, tissue-level remodeling of the cellular ultrastructure, and transcriptional early immune signatures induced by SARS-CoV-2 in a physiologically relevant model.
[Cell Reports Medicine]
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Post-Transcriptional Air Pollution Oxidation to the Cholesterol Biosynthesis Pathway Promotes Pulmonary Stress Phenotypes

Investigators develop a method for 8-oxo-7,8-dihydroguanine profiling using immunocapturing and RNA sequencing. They found 42 oxidized transcripts in bronchial epithelial BEAS-2B cells exposed to two air pollution mixtures that recreate urban atmospheres.
[Communications Biology]
Gonzalez-Rivera, J. C., Baldridge, K. C., Wang, D. S., Patel, K., Chuvalo-Abraham, J. C. L., Hildebrandt Ruiz, L., & Contreras, L. M. (2020). Post-transcriptional air pollution oxidation to the cholesterol biosynthesis pathway promotes pulmonary stress phenotypes. Communications Biology, 3(1), 1–16. https://doi.org/10.1038/s42003-020-01118-6 Cite
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Sanford Burnham Prebys Receives CIRM Award for COVID-19 Research

Sanford Burnham Prebys Medical Discovery Institute has received an award from the California Institute for Regenerative Medicine to advance promising drug candidates for COVID-19.
[Sanford Burnham Prebys Medical Discovery Institute]
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