ACPA Decreases Non-Small Cell Lung Cancer Line Growth through Akt/PI3K and JNK Pathways In Vitro

Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
[Cell Death & Disease]
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CXCR4 Uses STAT3-Mediated Slug Expression to Maintain Radioresistance of Non-Small Cell Lung Cancer Cells: Emerges as a Potential Prognostic Biomarker for Lung Cancer

Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in nonsmall cell lung cancer cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.
[Cell Death & Disease]
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AXL Is a Candidate Receptor for SARS-CoV-2 That Promotes Infection of Pulmonary and Bronchial Epithelial Cells

Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2, scientists found that overexpression of AXL in HEK293T cells promoted SARS-CoV-2 entry as efficiently as overexpression of ACE2, while knocking out AXL significantly reduced SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells.
[Cell Research]
Wang, S., Qiu, Z., Hou, Y., Deng, X., Xu, W., Zheng, T., Wu, P., Xie, S., Bian, W., Zhang, C., Sun, Z., Liu, K., Shan, C., Lin, A., Jiang, S., Xie, Y., Zhou, Q., Lu, L., Huang, J., & Li, X. (2021). AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell Research, 1–15. https://doi.org/10.1038/s41422-020-00460-y Cite
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Restored MicroRNA-519a Enhances the Radiosensitivity of Non-Small Cell Lung Cancer via Suppressing EphA2

Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in non-small cell lung cancer and paracancerous tissues were detected using RT-qPCR and western blot analysis.
[Gene Therapy]
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Genentech’s Novel Anti-TIGIT Tiragolumab Granted FDA Breakthrough Therapy Designation in Combination with Tecentriq for PD-L1-High Non-Small Cell Lung Cancer

Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq® for the first-line treatment of people with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.
[Genentech]
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Extracellular Vesicles‐Encapsulated let‐7i Shed from Bone Mesenchymal Stem Cells Suppress Lung Cancer via KDM3A/DCLK1/FXYD3 Axis

Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
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Lipid Peroxidation, GSH Depletion, and SLC7A11 Inhibition Are Common Causes of EMT and Ferroptosis in A549 Cells, but Different in Specific Mechanisms

The authors showed that ferroptosis in A549 cells was induced by Erastin, which decreased the expression levels of E-cadherin, α-SMA, and SLC7A11, accompanied with reactive oxygen species and malondialdehyde increase, as well as glutathione decrease.
[DNA and Cell Biology]
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The Aging Transcriptome and Cellular Landscape of the Human Lung in Relation to SARS-CoV-2

Deconvolution analysis revealed that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decreased with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21+ dendritic cells increased with age.
[Nature Communications]
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Intermittent Hypoxia-Induced Downregulation of MicroRNA-320b Promotes the Lung Cancer Tumorigenesis by Increasing CDT1 via USP37

Scientists explored the functional roles of microRNAs in lung cancer patients that were complicated with obstructive sleep apnea-hypopnea involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined.
[Molecular Therapy-Nucleic Acids]
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Cyclophilin A Inhibits A549 Cell Oxidative Stress and Apoptosis by Modulating the PI3K/Akt/mTOR Signaling Pathway

Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
[Bioscience Reports]
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Correction of CFTR Function in Intestinal Organoids to Guide Treatment of Cystic Fibrosis

Scientists studied cystic fibrosis transmembrane conductance regulator (CFTR) function in organoids of subjects with common and rare CFTR mutations and evaluated correlations between CFTR function and clinical data.
[European Respiratory Journal]
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