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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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The Role of the RS1-NEDD4-YAP1 Axis Orchestrates Epithelial-Macrophage Interplay in COPD
[Respiratory Research] Researchers integrated single-cell transcriptomics, conditional gene knockout mouse models, organoid culture, multiplex immunofluorescence validation, and flow cytometry to investigate the role of the RS1 gene in chronic obstructive pulmonary disease.
Alveolus-on-a-Chip: A Novel Tool for Modeling Lung Transplant Cold Storage Ischemia/Reperfusion Injury
[Transplantation] Investigators reported a novel cold storage ischemia/reperfusion injury model that incorporates physiological flow, stretch, and cell-cell interactions.
BRD4 Aggravates Acute Lung Injury by Inducing Ferroptosis in Alveolar Epithelial Cells
[Journal of Biochemical and Molecular Toxicology] Scientists investigated the mechanism by which BRD4 accelerates acute lung injury by promoting ferroptosis mediated by ANP32B/H3K27ac/MYC/HOXB8/BACH1 in alveolar epithelial cells.
An HDAC4-Specific PROTAC Degrader Achieves Radiation Sensitization by Enhancing Ferroptosis in Lung Cancer
[Nature Communications] The authors showed that HDAC4 promotes radiation resistance in lung cancer by inhibiting ferroptosis. Through a CRISPR screen in patient-derived organoids, they identified HDAC4 as a key mediator.
Multifactorial Sheltering in Peristromal Niches Shapes In Vivo Responses of Lung Cancers to Targeted Therapies
[Nature Communications] Using spatial histological inferences from ALK + NSCLC models, researchers showed that peristromal niches protect tumor cells from elimination, enabling in vivo persistence.
SNORD50A/B Disassemble ASC-1 Complex to Silence NF-κB and Boost PD-1 Blockade in Non-Small-Cell Lung Cancer
[NPJ Precision Oncology] Researchers observed that SNORD50A/B were frequently deleted in lung adenocarcinomas, and this molecular event was strongly linked to poor patient survival.
Silencing of NUP62 Overcomes Osimertinib Resistance via Ubiquitination of Survivin in Non-Small Cell Lung Cancer Cells
[British Journal of Cancer] Scientists identified nucleoporin 62 (NUP62) knockdown as a potential strategy to overcome osimertinib resistance in NSCLC and investigated the underlying molecular mechanisms.
Lipid Metabolic Reprogramming in Lung Cancer: Mechanisms and Therapeutic Targets in the Tumor Microenvironment
[International Journal of Cancer] The authors synthesize preclinical and clinical evidence to map the interconnected lipid metabolic networks spanning tumor, immune, and stromal compartments.
Verastem Oncology Announces US FDA Fast Track Designation for VS-7375, an Oral and Potential Best-in-Class Investigational KRAS G12D (ON/OFF) Inhibitor for the Treatment of...
[Verastem Oncology] Verastem Oncology announced that the FDA granted Fast Track Designation to VS-7375, an investigational oral KRAS G12D (ON/OFF) inhibitor, for previously treated patients with KRAS G12D-mutated advanced or metastatic NSCLC.
US Food and Drug Administration Approves FoundationOne®CDx as a Companion Diagnostic for TEPMETKO® (tepotinib) to Identify Patients with MET Exon 14 Skipping Alterations in...
[Foundation Medicine, Inc.] Foundation Medicine, Inc., announced that it has received approval from the US FDA for FoundationOne®CDx to be used as a companion diagnostic (CDx) for TEPMETKO® (tepotinib) developed by EMD Serono, the healthcare business of Merck KGaA, Darmstadt, Germany in the US and Canada.
Persistence of Alveolar Fibroblast-Derived ADAMTS4+ Cells in a Preclinical Model of Delayed Pulmonary Fibrosis Resolution
[Nature Communications] Lineage tracing of alveolar fibroblasts was carried out during fibrosis development and delayed resolution in aged mice. Histological analyses, single-cell transcriptomics, and ex vivo models including alveolar organoids and precision-cut lung slice cultures were employed.
Discovery of a Novel Lung-Restricted ALK5 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
[Journal of Medicinal Chemistry] Researchers develop a lung-restricted ALK5 inhibitor that shows strong antifibrotic activity in preclinical models, highlighting a targeted inhalation strategy for idiopathic pulmonary fibrosis.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
