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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Defining GRAMD2 Expression in the Alveolar Epithelium Using Organoid and Single Cell Approaches
[American Journal of Respiratory Cell and Molecular Biology] Researchers performed immunofluorescence of whole lung and cytospins of GFPhigh cells from Gramd2CreERT2;mTmG mice. They showed that GFPhigh cells were enriched for alveolar type (AT) I cells and formed organoids in culture that over time showed expression of ATII and airway markers.
Tongsai Granules Ameliorate Airway Mucus Hypersecretion in AECOPD by Remodeling LIPA-Driven Ceramide Metabolism
[Journal of Ethnopharmacology] Scientists aimed to investigate the mechanisms by which Tongsai Granules alleviate airway mucus hypersecretion in acute exacerbation of chronic obstructive pulmonary disease (AECOPD) through regulation of the lipase A (LIPA)/ceramide axis.
PINK1-Mediated Mitophagy Supports Lung Cancer Initiation and Limits the Efficacy of KRAS-Targeted Therapy
[Science Advances] Researchers investigated PTEN–induced kinase 1 (PINK1)-dependent mitophagy in human lung adenocarcinoma and directly monitored mitophagy in vivo using mito-QC reporter mice during lung tumor development.
Early Transcriptional Divergence and Spatial Remodeling toward Immune Activation and Evasion Shape Lung Adenocarcinoma Precancer Evolution
[Cancer Letters] Investigators integrated spatial transcriptomics with single-cell RNA sequencing to characterize inter- and intratumoral heterogeneity across hyperplasia, adenoma, and invasive adenocarcinoma in a genetically engineered mouse model.
MMP14-Mediated Proteolytic Cleavage of LAMC2 Domain III Fragment Drives Osimertinib Resistance in EGFR-Mutant Non-Small Cell Lung Cancer
[Acta Pharmacologica Sinica] Through quantitative secretomic profiling of paired osimertinib-sensitive and -resistant NSCLC cell lines, the authors identified laminin subunit γ2 (LAMC2) as markedly enriched in resistant cell secretomes.
PLA2G4A-Driven Arachidonic Acid Metabolic Reprogramming Promotes NSCLC Progression via the HSF1 Signaling Axis
[Cell Death Discovery] Scientists showed that cytosolic phospholipase A2 (PLA2G4A) is significantly upregulated in NSCLC patients and cell lines. Aberrant arachidonic acid metabolism is a hallmark of cancer, and PLA2G4A is the rate-limiting enzyme that initiates this cascade.
Hypoxia-Induced SATB Homeobox 2 Increases Hypoxia-Inducible Factor-1-Dependent Tumorigenesis and Drives Bevacizumab Resistance in Lung Adenocarcinoma
[Translational Oncology] By integrating lung adenocarcinoma (LUAD) cell models, murine tumor models, and spatial transcriptomics with reference-based cell-type deconvolution, investigators identified SATB2 as a previously unrecognized hypoxia-inducible epigenetic regulator in LUAD.
Nebulization-Stable Lipid-Polymer Hybrid Nanoparticles for mRNA Delivery in Advanced In Vitro Respiratory Models
[International Journal of Pharmaceutics] Researchers developed PEG-free lipid–polymer hybrid nanoparticles composed of a solid polylactic acid core and an engineered lipid corona to test the pulmonary delivery of messenger RNA that offers a promising strategy for local vaccination and treating respiratory diseases.
Bioinformatics Screening and Experimental Validation of Candidate Key Genes in Hyperoxia-Induced Acute Lung Injury
[Gene] Scientists sought to delineate candidate genes and associated signaling pathways involved in hyperoxia-induced acute lung injury through integrated transcriptomic analysis and experimental validation.
Oncogenic Mutations in Non-Small Cell Lung Cancer: From Molecular Mechanisms to Clinical Practice
[Signal Transduction and Targeted Therapy] The authors comprehensively summarize the efficacy and safety of tyrosine kinase inhibitors and targeted specific antibodies in advanced or metastatic patients with common or rare mutations, providing guidance in selecting the optimal agent.
Revolution Medicines Begins Treating Patients in Phase III RASolve 308 Trial Evaluating Zoldonrasib in Combination with Pembrolizumab and Chemotherapy as First-Line Treatment for Patients...
[Revolution Medicines, Inc.] Revolution Medicines, Inc. announced that it has begun treating patients in RASolve 308, a global Phase III clinical trial evaluating zoldonrasib, an investigational, RAS(ON) G12D-selective inhibitor, in combination with standard of care pembrolizumab plus chemotherapy as a first-line treatment in adult patients with metastatic RAS G12D non-squamous NSCLC.
JASCAYD™ Receives Health Canada Authorization for a New, Well-Tolerated Oral Treatment for Adults with IPF and PPF
[Boehringer Ingelheim Canada] Boehringer Ingelheim Canada announced that JASCAYDTM (nerandomilast) has received authorization from Health Canada for the treatment of adults with idiopathic pulmonary fibrosis (IPF) and adults with progressive pulmonary fibrosis (PPF).
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
