Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
[American Journal of Physiology-Cell Physiology]
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Heterogeneous Distribution of PD-L1 Expression in the IASLC/ATS/ERS Classification of Lung Adenocarcinoma

94 lung adenocarcinoma cases were reviewed in the Third Affiliated Hospital of Soochow University from January to December 2019. PD-L1 (DAKO 22C3) was used to test the PD-L1 expression in lung cancer tissue.
[International Journal of Clinical Oncology]
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Tenax Therapeutics Announces Clearance of the Investigational New Drug Application for Imatinib in Pulmonary Arterial Hypertension (PAH)

Tenax Therapeutics, Inc. announced that the FDA has reviewed and cleared its Investigational New Drug application for a novel formulation of imatinib.
[Tenax Therapeutics, Inc.]
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Antigen Presentation by Lung Epithelial Cells Directs CD4+TRM Cell Function and Regulates Barrier Immunity

Researchers reported that lung epithelial cells, including distinct surfactant protein C (SPC)lowMHChigh epithelial cells, functioned as anatomically-segregated and temporally-dynamic antigen presenting cells.
[Nature Communications]
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Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
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Biomarkers of Response to Checkpoint Inhibitors beyond PD-L1 in Lung Cancer

In this review, scientists address the state of PD-L1 testing in lung cancer, the role for tumor mutation burden as a predictive biomarker
[Modern Pathology]
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Contribution of p53 in Sensitivity to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.
[Scientific Reports]
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Hamster Organotypic Modeling of SARS-CoV-2 Lung and Brainstem Infection

Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.
[Nature Communications]
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Differentiation of Mouse Fetal Lung Alveolar Progenitors in Serum-Free Organotypic Cultures

Investigators reported serum-free conditions that allowed for growth and differentiation of mouse distal lung epithelial progenitors.
[eLife]
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Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
[European Journal of Pharmacology]
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Lung Cancer Stem Cells and Their Clinical Implications

Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]
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