Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

JMJD2C-Mediated Long Non-Coding RNA MALAT1/MicroRNA-503-5p/SEPT2 Axis Worsens Non-Small Cell Lung Cancer

Researchers explored the downstream mechanism of Jumonji domain containing protein 2C (JMJD2C) in NSCLC from the long non-coding RNA metastasis associated with lung adenocarcinoma transcript 1/microRNA-503-5p/septin 2 axis.
[Cell Death & Disease]
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Imaging Pulmonary Blood Vessels and Ventilation-Perfusion Mismatch in COVID-19

A severe pulmonary ventilation-perfusion mismatch usually triggers moderate to severe COVID-19 cases. Imaging can aid the physician in assessing severity of COVID-19.
[Molecular Imaging and Biology]
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LUMAKRAS® (Sotorasib) Receives Approval in Japan for Patients with KRAS G12C-Mutated Advanced Non-small Cell Lung Cancer

Amgen announced that LUMAKRAS® (sotorasib) has been approved in Japan for the treatment of KRAS G12C-mutated positive, unresectable, advanced and/or recurrent non-small cell lung cancer that has progressed after systemic anticancer therapy.
[Amgen, Inc.]
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Tissue-Level Alveolar Epithelium Model for Recapitulating SARS-CoV-2 Infection and Cellular Plasticity

Researchers presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that could recapitulate viral infection and cellular plasticity.
[Communications Biology]
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ISM1 Protects Lung Homeostasis via Cell-Surface GRP78-Mediated Alveolar Macrophage Apoptosis

Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.
[Proceedings of the National Academy of Sciences of the United States of America]
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Notch Pathway Inhibition Mediated by Arsenic Trioxide Depletes Tumor Initiating Cells in Small Cell Lung Cancer

Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway
[Molecular Biology Reports]
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FOXP3 Activated-LINC01232 Accelerates the Stemness of Non-Small Cell Lung Carcinoma by Activating TGF-β Signaling Pathway and Recruiting IGF2BP2 to Stabilize TGFBR1

Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research]
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Tissue-Level Alveolar Epithelium Model for Recapitulating SARS-CoV-2 Infection and Cellular Plasticity

Scientists presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that can recapitulate viral infection and cellular plasticity.
[Communications Biology]
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Development of Human Alveolar Epithelial Cell Models to Study Distal Lung Biology and Disease

Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.
[iScience]
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The Orphan Receptor GPRC5B Activates Pro-inflammatory Signaling in the Vascular Wall via Fyn and NFκB

In endothelial cells and vascular smooth muscle cells, stimulation with high glucose, TNFα or LPS induced a significant upregulation of endogenous GPRC5B mRNA and protein levels.
[Biochemical and Biophysical Research Communications]
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PLOD3 Regulates the Expression of YAP1 to Affect the Progression of Non-Small Cell Lung Cancer via the PKCδ/CDK1/LIMD1 Signaling Pathway

Silencing procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) promoted the cleavage ofprotein kinase C δ (PKCδ) in a caspase-dependent manner to generate a catalytically active fragment cleaved PKCδ, enhanced phosphorylation levels of CDK1, and LIMD1 but suppressed nuclear translocation of YAP1.
[Laboratory Investigation]
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