Investigators confirmed that CB1 receptor (CB1R) was expressed in non-small cell lung cancer cells in this study. Arachidonoylcyclopropylamide (ACPA) as a synthetic, CB1R-specific ligand decreased proliferation rate in NSCLC cells by WST-1 analysis and real-time proliferation assay.
[Cell Death & Disease]
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Researchers inferred that CXCR4 confers resistance to ionizing radiation (IR) in nonsmall cell lung cancer cells. Further, on the basis of colony forming ability, they found that drug-resistant A549/GR cells with improved CXCR4 expression exhibited more resistance to IR than A549 cells evidenced along with a reduction in the formation of γ-H2AX foci after IR.
[Cell Death & Disease]
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Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2, scientists found that overexpression of AXL in HEK293T cells promoted SARS-CoV-2 entry as efficiently as overexpression of ACE2, while knocking out AXL significantly reduced SARS-CoV-2 infection in H1299 pulmonary cells and in human primary lung epithelial cells.
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Wang, S., Qiu, Z., Hou, Y., Deng, X., Xu, W., Zheng, T., Wu, P., Xie, S., Bian, W., Zhang, C., Sun, Z., Liu, K., Shan, C., Lin, A., Jiang, S., Xie, Y., Zhou, Q., Lu, L., Huang, J., & Li, X. (2021). AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells. Cell Research, 1–15. https://doi.org/10.1038/s41422-020-00460-y Cite
Researchers investigated the role of miR-519a-targeted ephrinA2 receptor in radiosensitivity of NSCLC. miR-519a and EphA2 expression in non-small cell lung cancer and paracancerous tissues were detected using RT-qPCR and western blot analysis.
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Genentech announced that tiragolumab, a novel cancer immunotherapy designed to bind to TIGIT, has been granted Breakthrough Therapy Designation by the FDA, in combination with Tecentriq® for the first-line treatment of people with metastatic non-small cell lung cancer whose tumors have high PD-L1 expression with no EGFR or ALK genomic tumor aberrations.
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Scientists investigated the modulatory role of bone marrow mesenchymal stem cell‐EV‐derived let‐7i and their molecular mechanism in lung cancer progression.
[Journal of Cellular and Molecular Medicine]
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The authors showed that ferroptosis in A549 cells was induced by Erastin, which decreased the expression levels of E-cadherin, α-SMA, and SLC7A11, accompanied with reactive oxygen species and malondialdehyde increase, as well as glutathione decrease.
[DNA and Cell Biology]
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Deconvolution analysis revealed that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decreased with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21+ dendritic cells increased with age.
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Scientists explored the functional roles of microRNAs in lung cancer patients that were complicated with obstructive sleep apnea-hypopnea involving the deubiquitination enzyme. The miR-320b expression pattern in lung cancer tissues and cells was determined.
[Molecular Therapy-Nucleic Acids]
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Researchers showed the protective effect of human recombinant CypA on hydrogen peroxide-induced oxidative damage in A549 cells, which play crucial roles in lung cancer.
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Scientists studied cystic fibrosis transmembrane conductance regulator (CFTR) function in organoids of subjects with common and rare CFTR mutations and evaluated correlations between CFTR function and clinical data.
[European Respiratory Journal]
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