Circ-HMGA2 (hsa_circ_0027446) Promotes the Metastasis and Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells through the miR-1236-3p/ZEB1 Axis

Through microarray analysis, investigators obtained the circRNA expression profile of lung adenocarcinoma and found that circ-HMGA2, a novel RNA, was highly expressed in lung adenocarcinoma.
[Cell Death & Disease]
Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis | Cell Death & Disease. (n.d.). Retrieved March 25, 2021, from https://www.nature.com/articles/s41419-021-03601-2 Cite
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Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes

Postchronic single-walled carbon nanotubes (SWCNTs) exposed human lung cell model were established to investigate SWCNT-induced carcinogenesis.
[ACS Nano]
Wang, J., Tian, X., Zhang, J., Tan, L., Ouyang, N., Jia, B., Chen, C., Ge, C., & Li, J. (2021). Postchronic Single-Walled Carbon Nanotube Exposure Causes Irreversible Malignant Transformation of Human Bronchial Epithelial Cells through DNA Methylation Changes. ACS Nano. https://doi.org/10.1021/acsnano.1c00239 Cite
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SARS-CoV-2 Variants Reveal Features Critical for Replication in Primary Human Cells

By integrating viral sequencing data from patient material, virus stocks, and passaging experiments, together with kinetic virus replication data from nonhuman Vero-CCL81 cells and primary differentiated human bronchial epithelial cells (BEpCs), scientists observed several SARS-CoV-2 features that associated with distinct phenotypes.
[PLOS Biology]
Pohl, M. O., Busnadiego, I., Kufner, V., Glas, I., Karakus, U., Schmutz, S., Zaheri, M., Abela, I., Trkola, A., Huber, M., Stertz, S., & Hale, B. G. (2021). SARS-CoV-2 variants reveal features critical for replication in primary human cells. PLOS Biology, 19(3), e3001006. https://doi.org/10.1371/journal.pbio.3001006 Cite
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Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression

Investigators showed that the levels of kindlin-2 and its binding partner PYCR1, a key enzyme for proline synthesis, were significantly increased in the lung tissues of human patients with pulmonary fibrosis.
[American Journal of Respiratory Cell and Molecular Biology]
Zhang, P., Wang, J., Luo, W., Yuan, J., Cui, C., Guo, L., & Wu, C. (2021). Kindlin-2 Acts as a Key Mediator of Lung Fibroblast Activation and Pulmonary Fibrosis Progression. American Journal of Respiratory Cell and Molecular Biology. https://doi.org/10.1165/rcmb.2020-0320OC Cite
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MZT2A Promotes NSCLC Viability and Invasion by Increasing Akt Phosphorylation via the MOZART2 Domain

Scientists showed that mitotic spindle organizing protein 2A (MZT2A) exhibited oncogenic activity by activating galectin‐3‐binding protein and Akt in NSCLC.
[Cancer Science]
Wang, H., Jiang, X., Cheng, Y., Ren, H., Hu, Y., Zhang, Y., Su, H., Zou, Z., Wang, Q., Liu, Z., Zhang, J., & Qiu, X. (n.d.). MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain. Cancer Science, n/a(n/a). https://doi.org/https://doi.org/10.1111/cas.14900 Cite
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Long-Term Evolution of the Epithelial Cell Secretome in Preclinical 3D Models of the Human Bronchial Epithelium

Investigators developed a 3D model of the human bronchial epithelium using Calu-3 cell line and demonstrated its viability and functionality for 21 days without subculturing.
[Scientific Reports]
Sanchez-Guzman, D., Boland, S., Brookes, O., Mc Cord, C., Lai Kuen, R., Sirri, V., Baeza Squiban, A., & Devineau, S. (2021). Long-term evolution of the epithelial cell secretome in preclinical 3D models of the human bronchial epithelium. Scientific Reports, 11(1), 6621. https://doi.org/10.1038/s41598-021-86037-0 Cite
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Tissue-Specific Transplantation Antigen P35B Functions as an Oncogene and is Regulated by Microrna-125a-5p in Lung Cancer

Researchers demonstrated that tissue‑specific transplantation antigen P35B (TSTA3) was regulated by miR‑125a‑5p and functions as an oncogene in lung cancer via promoting the activation of β‑catenin signaling.
[Oncology Reports]
Gao, Y., Zhang, G., Liu, J., & Li, H. (2021). Tissue-specific transplantation antigen P35B functions as an oncogene and is regulated by microRNA-125a-5p in lung cancer. Oncology Reports, 45(5), 1–13. https://doi.org/10.3892/or.2021.8023 Cite
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ARIKAYCE® (Amikacin Liposome Inhalation Suspension) Approved by Japan’s Ministry of Health, Labour and Welfare for the Treatment of Patients with NTM Lung Disease Caused by MAC Who Did Not Sufficiently Respond to Prior Treatment with MDR

Insmed Incorporated announced that Japan’s Ministry of Health, Labour and Welfare has approved ARIKAYCE ® for the treatment of patients with nontuberculous mycobacterial lung disease caused by Mycobacterium avium complex who did not sufficiently respond to prior treatment with a multidrug regimen. The launch of ARIKAYCE in Japan is anticipated in mid-2021.
[Insmed, Inc.]
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GRP78 in Lung Cancer

The authors reviewed the functions and mechanisms of glucose-regulating protein 78 (GRP78) in the pathological processes of lung cancer, including tumorigenesis, apoptosis, autophagy, progression, and drug resistance, giving a comprehensive understanding of the function of GRP78 in lung cancer. They also discussed the potential role of GRP78 as a prognostic biomarker and therapeutic target for lung cancer.
[Journal of Translational Medicine]
Xia, S., Duan, W., Liu, W., Zhang, X., & Wang, Q. (2021). GRP78 in lung cancer. Journal of Translational Medicine, 19(1), 118. https://doi.org/10.1186/s12967-021-02786-6 Cite
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miR‑454‑3p Inhibits Non‑Small Cell Lung Cancer Cell Proliferation and Metastasis by Targeting TGFB2

miR‑454‑3p overexpression led to the suppression of proliferation, migration, and invasion in A549 and NCI‑H1650 cells. The overexpression of miR‑454‑3p in A549 and NCI‑H1650 cells significantly inhibited EMT. TGFB2 was revealed to be a direct target of miR‑454‑3p by using TargetScan database and luciferase reporter assay.
[Oncology Reports]
Liao, H., Liang, Y., Kang, L., Xiao, Y., Yu, T., & Wan, R. (2021). miR‑454‑3p inhibits non‑small cell lung cancer cell proliferation and metastasis by targeting TGFB2. Oncology Reports, 45(5), 1–12. https://doi.org/10.3892/or.2021.8018 Cite
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Anti-Cancer Effects of Polyphenol-Rich Sugarcane Extract

Investigators showed that polyphenol-rich sugarcane extract exerted anti-cancer properties on a range of cancer cells including human and mouse colon cancer cells lines; human lung cancer, human ovarian cancer, pro-monocytic human leukemia and mouse melanoma cell lines
[PLoS One]
Prakash, M. D., Stojanovska, L., Feehan, J., Nurgali, K., Donald, E. L., Plebanski, M., Flavel, M., Kitchen, B., & Apostolopoulos, V. (2021). Anti-cancer effects of polyphenol-rich sugarcane extract. PLOS ONE, 16(3), e0247492. https://doi.org/10.1371/journal.pone.0247492 Cite
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