Culture with Apically Applied Healthy or Disease Sputum Alters the Airway Surface Liquid Proteome and Ion Transport across Human Bronchial Epithelial Cells.

Researchers investigated how culture of normal human bronchial epithelial cells with apically applied secretions from healthy or disease lungs affected epithelial function with a view to providing better in vitro models of the in vivo environment.
[American Journal of Physiology-Cell Physiology]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Heterogeneous Distribution of PD-L1 Expression in the IASLC/ATS/ERS Classification of Lung Adenocarcinoma

94 lung adenocarcinoma cases were reviewed in the Third Affiliated Hospital of Soochow University from January to December 2019. PD-L1 (DAKO 22C3) was used to test the PD-L1 expression in lung cancer tissue.
[International Journal of Clinical Oncology]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Tenax Therapeutics Announces Clearance of the Investigational New Drug Application for Imatinib in Pulmonary Arterial Hypertension (PAH)

Tenax Therapeutics, Inc. announced that the FDA has reviewed and cleared its Investigational New Drug application for a novel formulation of imatinib.
[Tenax Therapeutics, Inc.]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Press Release
Bookmark

No account yet? Register

Share

Antigen Presentation by Lung Epithelial Cells Directs CD4+TRM Cell Function and Regulates Barrier Immunity

Researchers reported that lung epithelial cells, including distinct surfactant protein C (SPC)lowMHChigh epithelial cells, functioned as anatomically-segregated and temporally-dynamic antigen presenting cells.
[Nature Communications]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Cis-Acting Lnc-Cxcl2 Restrains Neutrophil-Mediated Lung Inflammation by Inhibiting Epithelial Cell CXCL2 Expression in Virus Infection

Scientists identified an inducible lncRNA in the Cxcl2 gene locus, lnc-Cxcl2, which could selectively inhibit Cxcl2 expression in mouse lung epithelial cells but not in macrophages.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Biomarkers of Response to Checkpoint Inhibitors beyond PD-L1 in Lung Cancer

In this review, scientists address the state of PD-L1 testing in lung cancer, the role for tumor mutation burden as a predictive biomarker
[Modern Pathology]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Contribution of p53 in Sensitivity to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.
[Scientific Reports]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Hamster Organotypic Modeling of SARS-CoV-2 Lung and Brainstem Infection

Researchers developed and characterized two new organotypic cultures from hamster brainstem and lung tissues that offered a unique opportunity to study the early steps of viral infection and screening antivirals.
[Nature Communications]
[zotpress userid=” items=’45XWATNZ’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Differentiation of Mouse Fetal Lung Alveolar Progenitors in Serum-Free Organotypic Cultures

Investigators reported serum-free conditions that allowed for growth and differentiation of mouse distal lung epithelial progenitors.
[eLife]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Stereospecific Inhibition of AMPK by (R)-Crizotinib Induced Changes to the Morphology and Properties of Cancer and Cancer Stem Cell-Like Cells

While (R)-crizotinib induced changes in morphologies or sizes of cells, (S)-crizotinib did not. Pretreatment with (R)-crizotinib suppressed the proliferation of cancer or CSC-like cells in vitro and tumor growth in vivo.
[European Journal of Pharmacology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Lung Cancer Stem Cells and Their Clinical Implications

Mouse models of lung cancer have shown that lung CSCs reside in niches that are essential for the maintenance of stemness, plasticity, enable antitumor immune evasion, and provide metastatic potential.
[Cold Spring Harbor Perspectives in Medicine]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share