JMJD2C-Mediated Long Non-Coding RNA MALAT1/MicroRNA-503-5p/SEPT2 Axis Worsens Non-Small Cell Lung Cancer

Researchers explored the downstream mechanism of Jumonji domain containing protein 2C (JMJD2C) in NSCLC from the long non-coding RNA metastasis associated with lung adenocarcinoma transcript 1/microRNA-503-5p/septin 2 axis.
[Cell Death & Disease]
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Imaging Pulmonary Blood Vessels and Ventilation-Perfusion Mismatch in COVID-19

A severe pulmonary ventilation-perfusion mismatch usually triggers moderate to severe COVID-19 cases. Imaging can aid the physician in assessing severity of COVID-19.
[Molecular Imaging and Biology]
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LUMAKRAS® (Sotorasib) Receives Approval in Japan for Patients with KRAS G12C-Mutated Advanced Non-small Cell Lung Cancer

Amgen announced that LUMAKRAS® (sotorasib) has been approved in Japan for the treatment of KRAS G12C-mutated positive, unresectable, advanced and/or recurrent non-small cell lung cancer that has progressed after systemic anticancer therapy.
[Amgen, Inc.]
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Tissue-Level Alveolar Epithelium Model for Recapitulating SARS-CoV-2 Infection and Cellular Plasticity

Researchers presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that could recapitulate viral infection and cellular plasticity.
[Communications Biology]
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ISM1 Protects Lung Homeostasis via Cell-Surface GRP78-Mediated Alveolar Macrophage Apoptosis

Researchers reported that absence of isthmin 1 (ISM1) in mice led to increase in both alveolar macrophages number and functional heterogeneity, with enduring lung inflammation, progressive emphysema, and significant lung function decline, phenotypes similar to human obstructive pulmonary disease.
[Proceedings of the National Academy of Sciences of the United States of America]
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Notch Pathway Inhibition Mediated by Arsenic Trioxide Depletes Tumor Initiating Cells in Small Cell Lung Cancer

Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway
[Molecular Biology Reports]
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FOXP3 Activated-LINC01232 Accelerates the Stemness of Non-Small Cell Lung Carcinoma by Activating TGF-β Signaling Pathway and Recruiting IGF2BP2 to Stabilize TGFBR1

Flow cytometry and sphere formation assays indicated that LINC01232 significantly promoted non-small cell lung carcinoma cell stemness.
[Experimental Cell Research]
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Tissue-Level Alveolar Epithelium Model for Recapitulating SARS-CoV-2 Infection and Cellular Plasticity

Scientists presented a standardized primary alveolar cell culture method for establishing a human alveolar epithelium model that can recapitulate viral infection and cellular plasticity.
[Communications Biology]
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Development of Human Alveolar Epithelial Cell Models to Study Distal Lung Biology and Disease

Researchers used de-identified human remnant transplant lungs to develop a method to establish alveolar epithelial cell lines. The lines grew well in 2D culture as epithelial monolayers expressing lung progenitor markers.
[iScience]
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The Orphan Receptor GPRC5B Activates Pro-inflammatory Signaling in the Vascular Wall via Fyn and NFκB

In endothelial cells and vascular smooth muscle cells, stimulation with high glucose, TNFα or LPS induced a significant upregulation of endogenous GPRC5B mRNA and protein levels.
[Biochemical and Biophysical Research Communications]
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PLOD3 Regulates the Expression of YAP1 to Affect the Progression of Non-Small Cell Lung Cancer via the PKCδ/CDK1/LIMD1 Signaling Pathway

Silencing procollagen-lysine, 2-oxoglutarate 5-dioxygenase (PLOD3) promoted the cleavage ofprotein kinase C δ (PKCδ) in a caspase-dependent manner to generate a catalytically active fragment cleaved PKCδ, enhanced phosphorylation levels of CDK1, and LIMD1 but suppressed nuclear translocation of YAP1.
[Laboratory Investigation]
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