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Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Kelun-Biotech Announces Phase III Study of Sacituzumab Tirumotecan (sac-TMT) in Combination with Pembrolizumab as First-Line Treatment for PD-L1-Negative Non-Squamous NSCLC Met Primary Endpoint
[Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. (PR Newswire)] Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. announced that its Phase III OptiTROP-Lung06 trial met its primary endpoint, with sac-TMT plus pembrolizumab significantly improving progression-free survival as a first-line treatment for PD-L1-negative advanced non-squamous NSCLC.
Kat5 Deficiency in Alveolar Type II Cells Licenses STAT6-Driven Glycolytic Reprogramming and Pulmonary Fibrosis
[Nature Communications] Researchers identified a Kat5-STAT6 epigenetic-metabolic axis that governs fibrotic progression. Kat5 directly acetylates STAT6 at lysine 636, thereby suppressing STAT6 dimerization, phosphorylation and nuclear translocation.
Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis
[Journal of the American Chemical Society] Scientists developed an inhalable dual-PROTAC nanotherapy that simultaneously degrades STING and BRD4, targeting epithelial senescence and fibroblast activation to reverse pulmonary fibrosis.
TGF-Alpha/EGFR Signalling Mediates Retinoic Acid-Induced Lung Repair
[NPJ Regenerative Medicine] The authors showed that retinoic acid induces endothelial angiogenesis, which is associated with enhanced paracrine signalling to alveolar epithelial cells.
Alveolar Type II Cell Therapy Ameliorates Pulmonary Fibrosis by Reprogramming Macrophage Activation
[Inflammation and Regeneration] Researchers showed that alveolar type II cell therapy alleviates pulmonary fibrosis by reprogramming profibrotic macrophages and restoring a pro-repair lung immune microenvironment.
Emodin Alleviates Radiation-Induced Pulmonary Fibrosis by Targeting Cellular Senescence via the mtDNA-cGAS-STING Axis
[Biogerontology] Scientists investigated whether emodin, a natural compound with known anti-aging properties, alleviates radiation-induced pulmonary fibrosis by suppressing radiation-induced cellular senescence.
Targeting TROP2 in Drug-Tolerant Persister Cells Delays EGFR Tyrosine Kinase Inhibitor Resistance in Non-Small-Cell Lung Cancer
[Cancer Cell] Researchers identified TROP2 as a vulnerability in drug-tolerant persister cells, showing that combining a TROP2-targeting antibody-drug conjugate with osimertinib delays resistance and tumor relapse in EGFR-mutant lung cancer.
SUMOylation Activates ECHS1 for Adaptive Catabolism in Lung Cancer
[Cell Death & Disease] Investigators identified SUMO1 modification at lysine 128 of ECHS1 as an essential activation switch that drives mitochondrial catabolism and restricts growth of lung cancer cells.
Chalcones As Multitarget Modulators in Non-Small Cell Lung Cancer: Mechanistic Insights and Therapeutic Perspectives
[Archives of Toxicology] Scientists highlight chalcones as multitarget compounds for non-small cell lung cancer, reviewing their potential to modulate tumor signaling, epithelial–mesenchymal transition, and therapy resistance.
Inhalable Polymeric PROTAC Nanococktail for Targeted Protein Degradation in Idiopathic Pulmonary Fibrosis
[Journal of the American Chemical Society] Researchers developed an inhalable enzyme-activated polymeric proteolysis-targeting chimera (PROTAC) nanococktail that enables concurrent degradation of two key profibrotic signaling regulators in fibrotic lungs.
Foxe1 Deficiency Impairs Thyroid Fate While Supporting Lung Differentiation
[EMBO Reports] By using mouse stem cell lines, scRNA-seq, and transcriptomic and chromatin accessibility profiling, scientists showed that Foxe1 knockout impairs Nkx2-1+ cell differentiation and maturation into thyroid follicular-like cells.
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis
[Cancer Discovery] Investigators discovered that breast cancer–derived lung metastases stimulate the proliferation of alveolar type II (AT2) cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
