Persistence of Alveolar Fibroblast-Derived ADAMTS4+ Cells in a Preclinical Model of Delayed Pulmonary Fibrosis Resolution

Lineage tracing of alveolar fibroblasts was carried out during fibrosis development and delayed resolution in aged mice. Histological analyses, single-cell transcriptomics, and ex vivo models including alveolar organoids and precision-cut lung slice cultures were employed.