Pulmonary Cell News

Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.

PRMT5-Mediated Methylation of STAT3 Is Required for Lung Cancer Stem Cell Maintenance and Tumor Growth

[Communications Biology] Investigators showed that PRMT5 directly methylated STAT3 and enhances its activated tyrosine phosphorylation in non-small cell lung cancer cells.

MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV-075) in Small-Cell Lung Cancer

[Molecular Cancer Research] Investigators described small-cell lung cancer cell lines harboring amplification of MYC and MYCN, but not MYCL1 nor non-amplified MYC cell lines, exhibited superior sensitivity to treatment with the pan-BET bromodomain protein inhibitor Mivebresib.

Vinpocetine Alleviated Alveolar Epithelial Cells Injury in Experimental Pulmonary Fibrosis by Targeting PPAR-γ/NLRP3/NF-κB and TGF-β1/Smad2/3 Pathways

[Molecular Cancer Research] Pulmonary fibrosis was induced in BALB/c mice by oropharyngeal aspiration of a single dose of bleomycin

Genome-Wide CRISPR Screens in Spheroid Culture Reveal That the Tumor Suppressor LKB1 Inhibits Growth via the PIKFYVE Lipid Kinase

[Proceedings Of The National Academy Of Sciences Of The United States Of America] To identify mechanisms of liver kinase B1 (LKB1)-mediated growth suppression, the authors developed a spheroid-based cell culture assay to study LKB1-dependent growth.

A Modified Orthotopic Left Lung Transplantation Model in Rats

[Heliyon] Researchers employed a modified three-cuff technique for the orthotopic left lung transplantation. Their modified perfusion method could prevent donor lung edema, while waist-shaped cuffs minimized suture slippage during anastomosis.

Recent Progress in Neonatal Hyperoxic Lung Injury

[Pediatric Pulmonology] Investigators analyze and summarize sex differences in neonatal hyperoxic lung injury, potential pathogenesis, and treatment progress to provide new ideas for basic and clinical research in this field.

First In Vitro Measurement of VHEE Relative Biological Effectiveness (RBE) in Lung and Prostate Cancer Cells Using the ARES Linac at DESY

[Scientific Reports] Investigators explored how electrons in the very high energy electrons (VHEE) range could be used to perform successful in vitro radiobiological studies.

Divarasib in the Evolving Landscape of KRAS G12C Inhibitors for NSCLC

[Targeted Oncology] Kristen Rat Sarcoma viral oncogene (KRAS) mutations are one of the most common oncogenic drivers found in 12–14% of NSCLC and 4% of colorectal cancer tumors.

A Virus-Inspired Inhalable Liponanogel Induces Potent Antitumor Immunity and Regression in Metastatic Lung Tumors

[Cancer Research] Inspired by the structure of a virus that utilized internal viral proteins to tune the loading and cytosolic delivery of viral nucleic acids, scientists developed a liponanogel-based platform to overcome the delivery challenges of poly(I:C).

Downregulation of Mirlet7 miRNA Family Promotes Tc17 Differentiation and Emphysema via De-repression of RORγt

[eLife] The authors demonstrated that loss of the Mirlet7b/Mirlet7c2 cluster in T cells predisposed mice to exaggerated cigarette smoke- or nanosized carbon black-elicited emphysema.

Iron Overload–Dependent Ferroptosis Aggravates LPS-Induced Acute Lung Injury by Impairing Mitochondrial Function

[Inflammation] Investigators observed a significant increase in iron concentration during acute lung injury, accompanied by elevated levels of lipid peroxidation markers such as malonaldehyde and 4-hydroxynonenal.

β-Catenin Turnover Is Regulated by Nek10-Mediated Tyrosine Phosphorylation in A549 Lung Adenocarcinoma Cells

[Proceedings Of The National Academy Of Sciences Of The United States Of America] Investigators observed that deletion of Nek10 in lung adenocarcinoma cells resulted in dramatic stabilization of β-catenin, suggestive of a Nek10 role in the control of β-catenin turnover.

Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

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