β-cells

[Nature Reviews Endocrinology] The focus of this Review is the description of how endocrine cell heterogeneity affects the regulation of hormone secretion within the islets of Langerhans.

[Scientific Reports] Copine 3 (CPNE3) is a calcium-dependent phospholipid-binding protein that has been found to play an essential role in cancer progression and stages. RNA sequencing and microarray data revealed that CPNE3 was highly expressed in human islets compared to other CPNE genes.

[Islets] Scientists identified genes that were specifically expressed in pancreatic islet β-cells. Large-scale complementary DNA-sequencing analysis was performed for 3,429 expressed sequence tags derived from murine MIN6 β-cells, through homology comparisons using the GenBank database.

[Pancreas] Adopting a 3D rotary cell culture system, researchers co-cultured several PDAC cell lines and MIN6 islet β cells.

[Cell Reports] MAFAS64F production in male human β cells accelerated cellular senescence and increase senescence-associated secretory proteins compared to cells expressing MAFAWT.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers presented ultrasound imaging of nanodroplet (ND) contrast-agent accumulation within the islet. ND accumulation is dependent on immune infiltration; therefore, it tracked presymptomatic type I diabetes development and progression to diabetes