β-cells

[Journal of Nutritional Biochemistry] Researchers investigated the short-term effect of 1α,25(OH)2 vitamin D3 and cholecalciferol on the glycemia and insulin sensitivity of control and dexamethasone-induced insulin-resistance in rats.

[Laboratory Investigation] ATP synthase inhibitory factor subunit 1 (IF1) is a mitochondrial protein interacting with ATP synthase to inhibit its enzyme activity. Scientists investigated islets freshly isolated from mouse lines with global inhibitory factor subunit 1 knockout (IF1−/−) and overexpression.

[Journal of Nutritional Biochemistry] Researchers explored the underlying mechanisms of type 2 diabetes prevention by vitamin D, concentrating on pancreatic iron deposition reported recently.

[Journal of Diabetes investigation] Recent research has suggested that transdifferentiation and dedifferentiation are involved in the decrease in β-cell volume and that it may change dynamically depending on the glucose metabolic state.

[Cold Spring Harbor Perspectives in Biology] Scientists describe the development and function of β-cells the emerging concept of heterogeneity within insulin-producing cells, and the potential of other cell types to assume β-cell functionality via transdifferentiation.

[Molecular Therapy-Nucleic Acids] Scientists experimentally verified one such micropeptide encoded by a β cell- and neural cell-enriched lncRNA TCL1 upstream neural differentiation-associated RNA. They provided the first evidence that lncRNA-encoded micropeptides played a critical role in pancreatic β cell functions and provided a foundation for future comprehensive analyses of micropeptide function and pathophysiological impact on diabetes.