β-cells

[Proceedings of the National Academy of Sciences of the United States of America] Using global stimulator of interferon genes (STING) knockout (STING−/−) and β-cell–specific STING knockout (STING-βKO) mouse models, scientists revealed a distinct role of STING in the regulation of glucose homeostasis through peripheral tissues and β-cells.

[Nature Communications] The authors showed that ICl,SWELL and SWELL1 protein were reduced in adipose and β-cells in murine and human diabetes.

[Nature Metabolism] In vitro expression of Mycl provoked active replication in islet cells, even in those from aged mice.

[Nature Communications] RNA-seq of purified recombined β-cells reveals transcriptomic consequences of Insr loss, which differ between female and male mice.

[Cell Metabolism] By screening the expression and functional characterization of olfactory receptors in pancreatic islets, investigators identified Olfr109 as the receptor that detects insulin peptides.

[Cellular Signalling] Scientists investigated whether the lncRNA MEG3 could regulate autophagy and pyroptosis through FOXO1 in pancreatic β-cells.