Axin2

[Cell Death & Disease] Researchers demonstrated that Zic2 was highly expressed in colon cancer tissues and correlated with poor survival. Knockdown of Zic2 inhibited colon cancer cell growth, arrested the cell cycle transition from G0/G1 to S phase, and suppressed tumor sphere formation in vitro.

[Biology] Using osteoblasts as a model system, scientists observed that prostate cancer cells and their conditioned medium could stimulate and increase mineralisation and osteoblasts’ differentiation.

[Cell Reports] To enable cell-type-specific gene manipulation in vitro, scientists establish an organoid system via coculture of endothelial cells (ECs), fibroblasts, and mammary epithelial cells.