BDNF

[Scientific Reports] Reseachers used chronic brain-derived neurotrophic factor (BDNF) treatment of defined-medium, serum-free spinal organotypic cultures to study intracellular calcium fluctuations.

[Scientific Reports] Scientists unravelled the down-stream pathways associated with mitochondrial complex II (CII) inhibition and compared with CI inhibition and the Manganese neurotoxicity. Genome-wide transcriptomics of N27 neuronal cells exposed to 3-nitropropionic acid, compared with 1-methyl-4-phenylpyridinium and Mn revealed varied transcriptomic profile.

[Journal of Materials Science-Materials in Medicine] Umbilical-cord blood vessels were isolated for decellularization and to establish endothelial cell culture. Cultured cells were characterized by immunophenotype, gene expression and in vitro angiogenesis assay.

[Scientific Reports] Scientists investigated the trophic potential of dental pulp stem cells-derived conditioned medium to protect and regenerate isolated primary trigeminal ganglion neuronal cells.

[Cell Reports Medicine] The authors report that elevating circulating unacylated-ghrelin, using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice.

[Cell Death & Disease] Investigators transfected HT22 cells with lentivirus--alpha-synuclein (α-Syn) shRNA, followed by brain-derived neurotrophic factor (BDNF) and manganese stimulation. In vitro experiments indicated that α-Syn selectively interacted with TrkB receptors and inhibited BDNF/TrkB signaling, leading to phosphorylation and downregulation of GluN2B.