CD133

[PLOS ONE] Researchers evaluated the independent and synergistic effect of metformin and sodium dichloroacetate on the metabolic activity, cell proliferation, and apoptosis of a canine prostate adenocarcinoma and a transitional cell carcinoma cell line in comparison to a primary canine fibroblast culture.

[Cellular Oncology] Cell line-derived spheroids, ex vivo intestinal organoid cultures and induced-pluripotent stem cells were used to investigate the role of atypical cyclin P in stemness.

[International Journal of Oncology] As the tumor microenvironment is typically acidic due to increased glycolysis and consequently leads to an increased production of lactic acid in tumor cells, the role of acid‑sensing ion channel 1a (ASIC1a), an acid sensor, was explored as a tumor suppressor in gliomagenesis and stemness.

[EMBO Journal] Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.

[Heliyon] The possible roles of human umbilical mesenchymal stromal cord and adipose mesenchymal stem cells in neurogenesis and synaptic function were investigated using a β-amyloid 1-42-induced Alzheimer's disease rat model.

[Acta Histochemica] Scientists investigated the expression of CD44 and CD133 in gastric cancer and non-neoplastic gastric mucosa. They used samples of primary gastric adenocarcinomas, metastatic lymph nodes, intestinal metaplasia, and histologically normal gastric tissues of surgical margins.