Immunobiology and Immunotherapy of HCC: Spotlight on Endothelial Specific YY1 Deletion Restricts Tumor Angiogenesis and Tumor Growthinnate and Innate-Like Immune Cells

VEGF-induced endothelial cell (EC) migration was diminished in Yin Yang 1 (YY1)-depleted HUVECs. A rescue experiment revealed that YY1-regulated BMP6 expression in ECs was involved in EC migration.
[Scientific Reports]
Ruf, B., Heinrich, B., & Greten, T. F. (2020). Immunobiology and immunotherapy of HCC: spotlight on innate and innate-like immune cells. Cellular & Molecular Immunology, 1–16. https://doi.org/10.1038/s41423-020-00572-w Cite
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Cardiovascular Tissue Regeneration System Based on Multiscale Scaffolds Comprising Double-Layered Hydrogels and Fibers

Mulltiscale scaffolds compartmentalized cells into the core region of cardiac tissue and the peripheral region of blood vessels to construct cardiovascular tissue, which was accomplished by a triple culture system of adipose-derived mesenchymal stem cells with C2C12 myoblasts on polycaprolactone fibers along with human umbilical vein endothelial cells (HUVECs) in fibrin hydrogel.
[Scientific Reports]
Kook, Y.-M., Hwang, S., Kim, H., Rhee, K.-J., Lee, K., & Koh, W.-G. (2020). Cardiovascular tissue regeneration system based on multiscale scaffolds comprising double-layered hydrogels and fibers. Scientific Reports, 10(1), 20321. https://doi.org/10.1038/s41598-020-77187-8 Cite
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In Vitro Modeling of Solid Tumor Interactions with Perfused Blood Vessels

Researchers introduced a microfluidic model of the solid tumor-vascular interface composed of a human umbilical vein endothelial cell (HUVEC)-lined, perfusable, bioengineered blood vessel and tumor spheroids embedded in an extracellular matrix.
[Scientific Reports]
Kwak, T. J., & Lee, E. (2020). In vitro modeling of solid tumor interactions with perfused blood vessels. Scientific Reports, 10(1), 20142. https://doi.org/10.1038/s41598-020-77180-1 Cite
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The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells

Scientists investigated whether the antihypertensive peptides Val-Pro-Pro (VPP) and Ile-Pro-Pro (IPP) ameliorate the effects of extracellular vesicles from Ang II-induced vascular smooth muscles on the endothelial dysfunction.
[Journal of Agricultural and Food Chemistry]
Song, T., Lv, M., Zhang, L., Zhang, X., Song, G., Huang, M., Zheng, L., & Zhao, M. (2020). The Protective Effects of Tripeptides VPP and IPP against Small Extracellular Vesicles from Angiotensin II-Induced Vascular Smooth Muscle Cells Mediating Endothelial Dysfunction in Human Umbilical Vein Endothelial Cells. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.0c05698 Cite
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Transport Properties of Statins by OATP1A2 and Regulation by Transforming Growth Factor-β (TGF-β) Signaling in Human Endothelial Cells

Cellular uptake and monolayer permeability of atorvastatin, pravastatin, and rosuvastatin were investigated, in vitro, using HUVECs.
[Journal of Pharmacology and Experimental Therapeutics]
Ronaldson, P. T., Brzica, H., Abdullahi, W., Reilly, B. G., & Davis, T. P. (2020). Transport Properties of Statins by OATP1A2 and Regulation by Transforming Growth Factor-β (TGF-β) Signaling in Human Endothelial Cells. Journal of Pharmacology and Experimental Therapeutics. https://doi.org/10.1124/jpet.120.000267 Cite
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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

Endothelial cells were isolated from human brain and analyzed by RNA sequencing. Human umbilical vein and human brain microvascular cells were used in both monolayer culture and endothelialized within a 3-dimensional printed vascular model of the middle cerebral artery.
[Stroke]
Kaneko Naoki, Satta Sandro, Komuro Yutaro, Muthukrishnan Sree Deepthi, Kakarla Visesha, Guo Lea, An Jennifer, Elahi Fanny, Kornblum Harley I., Liebeskind David S., Hsiai Tzung, & Hinman Jason D. (n.d.). Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection. Stroke, 0(0), STROKEAHA.120.032764. https://doi.org/10.1161/STROKEAHA.120.032764 Cite
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Docosahexaenoic Acid Reverses the Promoting Effects of Breast Tumor Cell-Derived Exosomes on Endothelial Cell Migration and Angiogenesis

By the time breast cancer cells were treated with DHA, RT-qPCR was used to investigate the expression of vascular endothelial growth factor (VEGF) and the selected pro- and anti-angiogenic microRNAs.
[Life Sciences]
Ghaffari-Makhmalbaf, P., Sayyad, M., Pakravan, K., Razmara, E., Bitaraf, A., Bakhshinejad, B., Goudarzi, P., Yousefi, H., Pournaghshband, M., Nemati, F., Fahimi, H., Rohollah, F., Hasanzad, M., Hashemi, M., Mousavi, S. H., & Babashah, S. (2020). Docosahexaenoic acid reverses the promoting effects of breast tumor cell-derived exosomes on endothelial cell migration and angiogenesis. Life Sciences, 118719. https://doi.org/10.1016/j.lfs.2020.118719 Cite
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Expression of CARD8 in Human Atherosclerosis and Its Regulation of Inflammatory Proteins in Human Endothelial Cells

The CARD8 mRNA was knocked-down in HUVECs in vitro, followed by quantitative RT-PCR analysis and OLINK Proteomics. Endothelial and smooth muscle cells in arterial tissue expressed CARD8 and CARD8 correlated with vWF, CD163 and the expression of inflammatory genes, such as CXCL1, CXCL6 and PDGF-A in plaque.
[Scientific Reports]
Paramel, G. V., Karadimou, G., Eremo, A. G., Ljungberg, L. U., Hedin, U., Olofsson, P. S., Folkersen, L., Berne, G. P., Sirsjö, A., & Fransén, K. (2020). Expression of CARD8 in human atherosclerosis and its regulation of inflammatory proteins in human endothelial cells. Scientific Reports, 10(1), 19108. https://doi.org/10.1038/s41598-020-73600-4 Cite
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Mesenchymal Stem Cell-Derived Exosomal MiR-145 Inhibit Atherosclerosis by targeting JAM-A

Scientists showed that microRNA-145 is associated with atherosclerosis by microRNA sequencing and bioinformatics analysis. MSC-derived miR-145 rich exosomes could efficiently deliver miR-145 from MSCs to human umbilical vein endothelial cells.
[Molecular Therapy-Nucleic Acids]
Yang, W., Yin, R., Zhu, X., Yang, S., Wang, J., Zhou, Z., Pan, X., & Ma, A. (2020). Mesenchymal Stem Cell-Derived Exosomal MiR-145 Inhibit Atherosclerosis by targeting JAM-A. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.037 Cite
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miRNA-126-3p Carried by Human Umbilical Cord Mesenchymal Stem Cell Enhances Endothelial Function through Exosome-Mediated Mechanisms In Vitro and Attenuates Vein Graft Neointimal Formation In Vivo

Human umbilical cord MSCs (hucMSCs) and human umbilical vein endothelial cells (HUVECs) were isolated from human umbilical cords and characterized by a series of experiments. Lentivirus vector encoding miRNA-126-3p was transfected into hucMSCs and verified by PCR.
[Stem Cell Research & Therapy]
Qu, Q., Wang, L., Bing, W., Bi, Y., Zhang, C., Jing, X., & Liu, L. (2020). miRNA-126-3p carried by human umbilical cord mesenchymal stem cell enhances endothelial function through exosome-mediated mechanisms in vitro and attenuates vein graft neointimal formation in vivo. Stem Cell Research & Therapy, 11(1), 464. https://doi.org/10.1186/s13287-020-01978-z Cite
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Pyruvate Kinase M2 Mediates the Glycolysis in the Lymphatic Endothelial Cells and Its Potential Relation to the Progression of Lymphatic Malformations

The glycolysis index, including glucose uptake, ATP and lactate production stayed at a relatively high level in human dermal lymphatic endothelial cells (HDLECs) compared with HUVECS, while inhibition of PKM2 by shikinon or PKM2 knockdown could significantly suppress glycolysis, migration, tubular formation, and invasion of HDLECs.
[American Journal of Pathology]
Jiang, H., Zou, Y., Zhao, J., Li, X., Yang, S., Zhou, X., Mou, D., Zhong, W., & Cai, Y. (2020). Pyruvate kinase M2 mediates the glycolysis in the lymphatic endothelial cells and its potential relation to the progression of lymphatic malformations. The American Journal of Pathology, 0(0). https://doi.org/10.1016/j.ajpath.2020.10.003 Cite
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