Disturbance of Cellular Homeostasis as a Molecular Risk Evaluation of Human Endothelial Cells Exposed to Nanoparticles

Researchers determined the effect of different types of nanoparticles on human endothelial cells and examined the types of toxicity responses they can induce.
[Scientific Reports]
Wigner, P., Zielinski, K., Michlewska, S., Danielska, P., Marczak, A., Ricci, E. J., Santos-Oliveira, R., & Szwed, M. (2021). Disturbance of cellular homeostasis as a molecular risk evaluation of human endothelial cells exposed to nanoparticles. Scientific Reports, 11(1), 3849. https://doi.org/10.1038/s41598-021-83291-0 Cite
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Human Umbilical Vein Endothelial Cells-Derived MicroRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

The authors investigated the potential of extracellular vesicles derived from human umbilical vein endothelial cells to transfer miR-203 to affect the progression of non-small cell lung cancer (NSCLC). miR-203 and p21 were poorly expressed while DTL was highly expressed both in NSCLC tissues and cell lines.
[Cancer Gene Therapy]
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The Effect of Endothelial Progenitor Cell Transplantation on Neointimal Hyperplasia and Reendothelialisation after Balloon Catheter Injury in Rat Carotid Arteries

Transplanted endothelial progenitor cells labelled with PKH26 were attached to the injured luminal surface the first day after balloon injury.
[Stem Cell Research & Therapy]
Wang, W., Zhang, Y., Hui, H., Tong, W., Wei, Z., Li, Z., Zhang, S., Yang, X., Tian, J., & Chen, Y. (2021). The effect of endothelial progenitor cell transplantation on neointimal hyperplasia and reendothelialisation after balloon catheter injury in rat carotid arteries. Stem Cell Research & Therapy, 12(1), 99. https://doi.org/10.1186/s13287-021-02135-w Cite
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Human Umbilical Vein Endothelial Cells-Derived microRNA-203-Containing Extracellular Vesicles Alleviate Non-Small-Cell Lung Cancer Progression through Modulating the DTL/p21 Axis

The authors investigated the potential of extracellular vesicles derived from HUVECs to transfer miR-203 to affect the progression of non-small cell lung cancer.
[Cancer Gene Therapy]
Ma, T., Hu, Y., Guo, Y., & Zhang, Q. (2021). Human umbilical vein endothelial cells-derived microRNA-203-containing extracellular vesicles alleviate non-small-cell lung cancer progression through modulating the DTL/p21 axis. Cancer Gene Therapy, 1–14. https://doi.org/10.1038/s41417-020-00292-3 Cite
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A GLP-1 Analog Lowers ER Stress and Enhances Protein Folding to Ameliorate Homocysteine-Induced Endothelial Dysfunction

Exendin-4 increased the expression of endoplasmic reticulum oxidoreductase, an important endothelial reticulum chaperone in endothelial cells, and this effect was mediated by AMPK activation.
[Acta Pharmacologica Sinica]
Cheng, C. K., Luo, J.-Y., Lau, C. W., Cho, W. C., Ng, C. F., Ma, R. C. W., Tian, X. Y., & Huang, Y. (2021). A GLP-1 analog lowers ER stress and enhances protein folding to ameliorate homocysteine-induced endothelial dysfunction. Acta Pharmacologica Sinica, 1–12. https://doi.org/10.1038/s41401-020-00589-x Cite
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Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices

In order to investigate effects of oxygen microenvironment and matrix composition on the 3D network formation, an upside‐down microfluidic cell culture device capable of generating oxygen gradients was developed.
[Small]
Hsu, H.-H., Ko, P.-L., Wu, H.-M., Lin, H.-C., Wang, C.-K., & Tung, Y.-C. (n.d.). Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices. Small, n/a(n/a), 2006091. https://doi.org/https://doi.org/10.1002/smll.202006091 Cite
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Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside‐Down Microfluidic Devices

In cell experiments, network formation of human umbilical vein endothelial cells (HUVECs) within fibrinogen‐based hydrogels with different concentrations of hyaluronic acid (HA) were systematically studied.
[Small]
Hsu, H.-H., Ko, P.-L., Wu, H.-M., Lin, H.-C., Wang, C.-K., & Tung, Y.-C. (n.d.). Study 3D Endothelial Cell Network Formation under Various Oxygen Microenvironment and Hydrogel Composition Combinations Using Upside-Down Microfluidic Devices. Small, n/a(n/a), 2006091. https://doi.org/https://doi.org/10.1002/smll.202006091 Cite
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Longitudinal Shear Stress Response in Human Endothelial Cells to Atheroprone and Atheroprotective Conditions

Investigators measured oscillatory shear and pulsatile shear transcriptomic responses in human aortic endothelial cells (HAECs) over 24 hours and compared these temporal responses of HAECs with our previous findings on HUVECs.
[Proceedings of the National Academy of Sciences of the United States of America]
Maurya, M. R., Gupta, S., Li, J. Y.-S., Ajami, N. E., Chen, Z. B., Shyy, J. Y.-J., Chien, S., & Subramaniam, S. (2021). Longitudinal shear stress response in human endothelial cells to atheroprone and atheroprotective conditions. Proceedings of the National Academy of Sciences, 118(4). https://doi.org/10.1073/pnas.2023236118 Cite
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Conditioned Media from Endothelial Progenitor Cells Cultured in Simulated Microgravity Promote Angiogenesis and Bone Fracture Healing

Human peripheral blood-derived endothelial progenitor cells were cultured under microgravity (MG) or normal gravity (NG) followed by analysis for angiogenic gene expression. Furthermore, the serum-free cultured medium under MG or NG were collected, and their pro-angiogenic properties were examined in HUVECs.
[Current Stem Cell Research & Therapy]
Kong, L., Wang, Y., Wang, H., Pan, Q., Zuo, R., Bai, S., Zhang, X., Lee, W. Y., Kang, Q., & Li, G. (2021). Conditioned media from endothelial progenitor cells cultured in simulated microgravity promote angiogenesis and bone fracture healing. Stem Cell Research & Therapy, 12(1), 47. https://doi.org/10.1186/s13287-020-02074-y Cite
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Exosomal LINC00161 Promotes Angiogenesis and Metastasis via Regulating miR-590-3p/ROCK Axis in Hepatocellular Carcinoma

Functional study demonstrated that exosomal LINC00161 derived from hepatocellular carcinoma (HCC)-cells were significantly associated with enhanced proliferation, migration, and angiogenesis in HUVECs in vitro, all of which were effectively inhibited when LINC00161 was sliced with shRNA in HCC-cells.
[Cancer Gene Therapy]
You, L.-N., Tai, Q.-W., Xu, L., Hao, Y., Guo, W.-J., Zhang, Q., Tong, Q., Zhang, H., & Huang, W.-K. (2021). Exosomal LINC00161 promotes angiogenesis and metastasis via regulating miR-590-3p/ROCK axis in hepatocellular carcinoma. Cancer Gene Therapy, 1–18. https://doi.org/10.1038/s41417-020-00269-2 Cite
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miR-217 Promotes Endothelial Cell Senescence through the SIRT1/p53 Signaling Pathway

Human umbilical vein endothelial cells (HUVECs) were used to replicate the aging model, and the population doubling levels during cell passage were counted. Senescence-associated β-galactosidase staining, real-time quantitative PCR, MTT assay, Transwell, and tube formation were used to detect the effects of miR-217 on young and senescent HUVECs.
[Journal of Molecular Histology]
Wang, Z., Shi, D., Zhang, N., Yuan, T., & Tao, H. (2021). MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway. Journal of Molecular Histology. https://doi.org/10.1007/s10735-020-09945-x Cite
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