Scientists developed an alginate-based scaffolding structure, which was processed using three-dimensional printing and electrospinning for use as a spheroid-entrapping structure.
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Researchers describe the design and synthesis of a panel of fluorinated L-fucose analogs bearing fluorine atoms at the C2 and/or C6 positions of L-fucose as metabolic fucosylation inhibitors. Preliminary study of their effects on cell proliferation revealed that the 6,6-difluoro-L-fucose and 6,6,6-trifluoro-L-fucose showed significant inhibitory activity against proliferation of human colon cancer cells and human umbilical vein endothelial cells.
[ACS Chemical Biology]
Palmitoyl-dl-carnitine chloride was used as a protein kinase C inhibitor to provide a cationic surface charge to LARPC. The formulation was characterized for particle size, zeta potential, drug release and various cell culture assays using HUVEC and vemurafenib resistant melanoma cells.
[Experimental Cell Research]
Scientists observed that hypoxic exosomes derived from pancreatic cancer cells promoted cell migration and tube formation of human umbilical vein endothelial cells.
[Molecular Therapy-Nucleic Acids]
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Guo, Z., Wang, X., Yang, Y., Chen, W., Zhang, K., Teng, B., Huang, C., Zhao, Q., & Qiu, Z. (2020). Hypoxic Tumor-derived Exosomal Long Noncoding RNA UCA1 Promotes Angiogenesis via miR-96-5p/AMOTL2 in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.08.021 Cite
Scientists showed that Zfp148 deficiency downregulated cell cycle genes in mouse embryonic fibroblasts in a p53-dependent manner.
Researchers report the design of a small molecule that specifically and potently enhanced VEGFA expression by the targeting of a non-coding microRNA that regulates its expression.
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Haniff, H. S., Knerr, L., Liu, X., Crynen, G., Boström, J., Abegg, D., Adibekian, A., Lekah, E., Wang, K. W., Cameron, M. D., Yildirim, I., Lemurell, M., & Disney, M. D. (2020). Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions. Nature Chemistry, 1–10. https://doi.org/10.1038/s41557-020-0514-4 Cite
A novel strategy was developed to support ex vivo expansion of hematopoietic stem and progenitor cells by coculture with engineered human umbilical arterial endothelial cells, which expressed E4ORF1 stably by using a retroviral system.
[Stem Cell Research & Therapy]
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Li, H., Pei, H., Wang, S., Zhang, B., Fan, Z., Liu, Y., Xie, X., Yang, Z., Xu, L., Jia, Y., Bai, Y., Han, Y., Chen, L., He, L., Nan, X., Yue, W., & Pei, X. (2020). Arterial endothelium creates a permissive niche for expansion of human cord blood hematopoietic stem and progenitor cells. Stem Cell Research & Therapy, 11(1), 358. https://doi.org/10.1186/s13287-020-01880-8 Cite
Scientists showed that berberine administration markedly ameliorated intralipid-induced insulin without affecting blood glucose, which was accompanied by alleviated mitochondrial swelling in skeletal muscle. They used human skeletal muscle cells, AML12 hepatocytes, HUVECs, and CypD knockout mice to investigate metabolic and molecular alternations.
[Acta Pharmacologica Sinica]
The authors showed that BVT-948-mediated SETD8 inhibition in HUVECs resulted in an inhibition of angiogenesis. Inhibition of SETD8 not only inhibited angiogenesis but also disrupted actin stress fiber formation and induced cell cycle arrest at S phase.
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Investigators showed that reduction of [Cl−]i inhibited HUVEC proliferation, migration, cytoskeleton reorganization, tube formation, and subsequently suppressed angiogenesis under basal condition, and VEGF stimulation or hypoxia treatment.
[Acta Pharmacologica Sinica]
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Li, K., Liu, Y., Lv, X., Lin, Z., Zhang, T., Zhang, F., Guo, J., Hong, Y., Liu, X., Lin, X., Zhou, J., Wu, Q., Liang, S., & Shang, J. (2020). Reduced intracellular chloride concentration impairs angiogenesis by inhibiting oxidative stress-mediated VEGFR2 activation. Acta Pharmacologica Sinica, 1–13. https://doi.org/10.1038/s41401-020-0458-7 Cite
Investigators evaluated cellular senescence, interleukin 8 concentrations, and angiogenesis using β-galactosidase staining, enzyme-linked immunosorbent assay, and in vitro assays, respectively.