Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing through MiR-17-5p-mediated Enhancement of Angiogenesis

Researchers investigated the effects of extracellular vehicles secreted by human umbilical cord mesenchymal stem cells on angiogenesis under high glucose conditions in vivo and in vitro and to explore the underlying mechanisms.
[Stem Cell Reviews and Reports]
Wei, Q., Wang, Y., Ma, K., Li, Q., Li, B., Hu, W., Fu, X., & Zhang, C. (2021). Extracellular Vesicles from Human Umbilical Cord Mesenchymal Stem Cells Facilitate Diabetic Wound Healing Through MiR-17-5p-mediated Enhancement of Angiogenesis. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-021-10176-0 Cite
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Human Acellular Amniotic Membrane Incorporating Exosomes from Adipose-Derived Mesenchymal Stem Cells Promotes Diabetic Wound Healing

ADSC-derived exosomes enhanced the proliferation and migration of human dermal fibroblasts and promoted proliferation and tube formation of human umbilical vein endothelial cells in vitro.
[Stem Cell Research & Therapy]
Xiao, S., Xiao, C., Miao, Y., Wang, J., Chen, R., Fan, Z., & Hu, Z. (2021). Human acellular amniotic membrane incorporating exosomes from adipose-derived mesenchymal stem cells promotes diabetic wound healing. Stem Cell Research & Therapy, 12(1), 255. https://doi.org/10.1186/s13287-021-02333-6 Cite
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Complement Activation by an Angiogenic Imbalance Leads to Systemic Vascular Endothelial Dysfunction: A New Proposal for the Pathophysiology of Preeclampsia

Scientists evaluated whether angiogenic imbalance affected the expression and secretion of inhibitory complement factor H in endothelial cells, resulting in complement activation and systemic vascular endothelial dysfunction.
[Journal of Reproductive Immunology]
Matsuyama, T., Tomimatsu, T., Mimura, K., Yagi, K., Kawanishi, Y., Kakigano, A., Nakamura, H., Endo, M., & Kimura, T. (2021). Complement activation by an angiogenic imbalance leads to systemic vascular endothelial dysfunction: A new proposal for the pathophysiology of preeclampsia. Journal of Reproductive Immunology, 145, 103322. https://doi.org/10.1016/j.jri.2021.103322 Cite
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Scaffolds from Self-Assembling Tetrapeptides Support 3D Spreading, Osteogenic Differentiation, and Angiogenesis of Mesenchymal Stem Cells

The authors describe self-assembling tetrapeptide scaffolds for the growth and osteogenic differentiation of human MSCs. The rationally designed peptides are synthetic amphiphilic self-assembling peptides composed of four amino acids that are nontoxic.
[Biomacromolecules]
Alshehri, S., Susapto, H. H., & Hauser, C. A. E. (2021). Scaffolds from Self-Assembling Tetrapeptides Support 3D Spreading, Osteogenic Differentiation, and Angiogenesis of Mesenchymal Stem Cells. Biomacromolecules. https://doi.org/10.1021/acs.biomac.1c00205 Cite
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Apatinib Suppresses the Migration, Invasion and Angiogenesis of Hepatocellular Carcinoma Cells by Blocking VEGF and PI3K/AKT Signaling Pathways

Apatinib was used to treat hepatocellular carcinoma (HCC) cells transfected with or without VEGFR2 overexpression vectors. The proliferation of HCC cells was detected by MTT assay.
[Molecular Medicine Reports]
Song, J., Guan, Z., Song, C., Li, M., Gao, Z., & Zhao, Y. (2021). Apatinib suppresses the migration, invasion and angiogenesis of hepatocellular carcinoma cells by blocking VEGF and PI3K/AKT signaling pathways. Molecular Medicine Reports, 23(6), 1–8. https://doi.org/10.3892/mmr.2021.12068 Cite
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Pancreatic Cancer Cells-Derived Exosomal Long Non-coding RNA CCAT1/microRNA-138-5p/HMGA1 Axis Promotes Tumor Angiogenesis

The research was implemented to figure out the concrete role of pancreatic cancer (PC) cells-derived exosomal long non-coding RNA colon cancer-associated transcript-1 (CCAT1) in PC with its regulation on microRNA-138-5p/high mobility group A1 (miR-138-5p/HMGA1) axis.
[Life Sciences]
Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis. (2021). Life Sciences, 119495. https://doi.org/10.1016/j.lfs.2021.119495 Cite
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Paracrine Interleukin-8 Affects Mesenchymal Stem Cells through the Akt Pathway and Enhances Human Umbilical Vein Endothelial Cell Proliferation and Migration

Cultured human umbilical vein endothelial cells (HUVECs) were cultured in bone marrow mesenchymal stem cell conditioned medium
[Bioscience Reports]
wang, L., Li, Y., Zhang, X., Liu, N., Shen, S., Sun, S., Jiang, Y., Li, P., Jin, H., & Shen, L. (2021). Paracrine Interleukin-8 affects mesenchymal stem cells through the Akt pathway and enhances human umbilical vein endothelial cell proliferation and migration. Bioscience Reports, BSR20210198. https://doi.org/10.1042/BSR20210198 Cite
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LncRNA GAS5 Activates the HIF1A/VEGF Pathway by Binding to TAF15 to Promote Wound Healing in Diabetic Foot Ulcers

Scientists aimed to investigate the role of GAS5 in wound healing in diabetic foot ulcer as well as the underlying mechanism.
[Laboratory Investigation]
Peng, W.-X., He, P.-X., Liu, L.-J., Zhu, T., Zhong, Y.-Q., Xiang, L., Peng, K., Yang, J.-J., & Xiang, G.-D. (2021). LncRNA GAS5 activates the HIF1A/VEGF pathway by binding to TAF15 to promote wound healing in diabetic foot ulcers. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-021-00598-2 Cite
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Ferritinophagy Is Involved in the Zinc Oxide Nanoparticles-Induced Ferroptosis of Vascular Endothelial Cells

Scientists report that zinc oxide nanoparticles can induce ferroptosis of both HUVECs and EA.hy926 cells, as evidenced by the elevation of intracellular iron levels, lipid peroxidation and cell death in a dose- and time-dependent manner.
[Autophagy]
Qin, X., Zhang, J., Wang, B., Xu, G., Yang, X., Zou, Z., & Yu, C. (2021). Ferritinophagy is involved in the zinc oxide nanoparticles-induced ferroptosis of vascular endothelial cells. Autophagy, 0(0), 1–20. https://doi.org/10.1080/15548627.2021.1911016 Cite
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The CREB/KMT5A Complex Regulates PTP1B to Modulate High Glucose-Induced Endothelial Inflammatory Factor Levels in Diabetic Nephropathy

The authors hypothesized that cAMP response element-binding protein (CREB) associated with KMT5A to modulate PTP1B expression, thus contributing to high glucose-mediated glomerular endothelial inflammation.
[Cell Death & Disease]
Huang, T., Li, X., Wang, F., Lu, L., Hou, W., Zhu, M., & Miao, C. (2021). The CREB/KMT5A complex regulates PTP1B to modulate high glucose-induced endothelial inflammatory factor levels in diabetic nephropathy. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03629-4 Cite
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Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells

HUVECs and human lung microvascular endothelial cells incubated with human sickle cell plasma had significant increases in pro-inflammatory IL-8, IL-6, and soluble VCAM-1 secretion compared to endothelial cells incubated with normal plasma.
[Frontiers in Immunology]
Zhang, P., Nguyen, J., Abdulla, F., Nelson, A. T., Beckman, J. D., Vercellotti, G. M., & Belcher, J. D. (2021). Soluble MD-2 and Heme in Sickle Cell Disease Plasma Promote Pro-Inflammatory Signaling in Endothelial Cells. Frontiers in Immunology, 12. https://doi.org/10.3389/fimmu.2021.632709 Cite
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