NLRP3

[Free Radical Biology and Medicine] Investigators characterized how Prototheca bovis induced inflammatory responses in mouse mammary gland tissue and mammary epithelial cells.

[Cell Death & Disease] Scientists evaluated the anti-inflammatory effects and potential mechanisms of action of 3TC in vitro in retinal microvascular endothelial cells treated with high-glucose and lipopolysaccharide.

[Free Radical Biology and Medicine] Scientists investigated the important role and mechanism of C3a in preventing the occurrence of pyroptosis to protect the lung endothelial cells in sepsis-induced acute lung injury.

[American Journal of Pathology] The authors review evidence of NOD-like receptor (NLR) P3 activation in IPF, of NLRP3 inhibition in different animal models of fibrosis, and highlight the recent advances in direct and indirect NLRP3 inhibitors.

[Cell Death & Disease] Irisin effectively inhibited β-GP-induced calcium deposition in VSMCs in vitro and in mice aortic rings ex vivo. Overexpression of Nlrp3 attenuated the suppressive effect of Irisin on VSMC calcification.

[Journal of Hepatology] Researchers investigated the role of X-box binding protein-1 (XBP1) in the progression of non-alcoholic steatohepatitis.