NSCLC

[Signal Transduction and Targeted Therapy] Scientists identified two 4q12 long noncoding RNAs LCETRL3 and LCETRL4 which could significantly dimmish EGFR-TKIs efficiency.

[Thoracic Cancer] GEPIA database was employed to reveal the expression level of Ovarian tumor protease domain-containing protein 1 (OTUD1) in addition to Krüppel- like factor 4 (KLF4) in NSCLC tissue samples and prove the correlation between OTUD1 and KLF4.

[Scientific Reports] The high expression of NEK2/3mRNA was significantly associated with poor prognosis in patients with NSCLC, while high expression of NEK1/4/6/7/8/9/10/11mRNA was associated with good prognosis.

[Nature Communications] By utilizing a ΔNp63-specific conditional knockout mouse model and xenograft models of lung adenocarcinoma and squamous cell carcinoma, scientists found that ∆Np63 promoted NSCLC by maintaining the lung stem cells necessary for lung cancer cell initiation and progression in quiescence.

[Cell Communication and Signaling] The biological role of copine 1 (CPNE1) and receptor for activated C kinase 1 (RACK1) in NSCLC was investigated using gene expression knockdown and overexpression, cell proliferation assays, clonogenic assays, and Transwell assays.

[Lung Cancer Research Foundation] The Lung Cancer Research Foundation (LCRF) and KRAS Kickers announced a partnership aimed at raising much needed funds for research. Together they to pledge to fund at least one two-year grant in 2022 with the goal of improving outcomes for people with KRAS-mutant lung cancer.