PDAC cells

[Oncogene] Scientists found that the 18fluoro-deoxyglucose positron emission tomography/computed tomography-based markers were positively associated with the expression of programmed cell death ligand 1, pyruvate kinase M2, both of which indicate poor prognosis in patients with pancreatic ductal adenocarcinoma.

[Cell Reports] Pharmacologic inhibition of CHK1 alone caused apoptotic growth suppression of both PDAC cell lines and organoids, which correlated with loss of MYC expression.

[Nature Communications] Scientists found that 41 and 84 microRNA inhibitors enhanced the sensitivity of Capan1 and MiaPaCa2 pancreatic ductal adenocarcinoma cells respectively.

[Scientific Reports] Scientists clarified the role and mechanisms of action of apoptosis-associated speck-like protein containing a caspase recruitment domain in pancreatic ductal adenocarcinoma using clinical evidence and in vitro data.

[Molecules] Scientists investigated whether the autophagy inhibitor chloroquine could potentiate the anticancer effect of pterostilbene in the PDAC cell lines MIA PaCa-2 and BxPC-3, as well as in an orthotopic animal model.

[Cancers] Researchers showed that inhibition of RAC1 activation attenuated pluripotency marker expression and self-renewal ability, while depletion of RAC1b dramatically enhanced stemness features and clonogenic potential.