PDAC cells

[Nature Communications] Researchers derived pancreatic ductal adenocarcinoma organoids from 18 primary tumors and two matched liver metastases, and showed that ‘classical’ and ‘basal-like’ cells coexist in individual organoids.

[Molecular Cancer Therapeutics] Investigators showed that IL-1α was overexpressed in both murine and human pancreatic ductal adenocarcinomatumors and engaged with its cognate receptor IL-1R1 which was strongly expressed on stromal cells.

[Scientific Reports] Using quantitative real-time RT-PCR and western blot analysis, scientists analysed the changes in the expression of HA-synthesizing enzymesand hyaluronan HA-degrading enzymes in pancreatic ductal adenocarcinoma cell lines under hypoxic conditions.

[International Journal of Radiation Oncology Biology Physics] In a panel of 3D, extracellular matrix based PDAC cell cultures, β1 integrin was inhibited by antibodies or siRNA-mediated knockdown. Together with X-ray irradiation and specific chemotherapies, scientists determined 3D colony formation capacity in therapy-naïve and radioresistant PDAC cultures.

[ACS Nano] Investigators developed a size switchable nanosystem based on PEG–PLGA nanospheres encapsulated within liposomes for the combined delivery of vactosertib, a TGF-β1 receptor kinase inhibitor, and the cytotoxic drug paclitaxel.

[Cancer Cell International] Researchers analyzed the expression of BCL10-, cell cycle-, and NF-κB- related signaling molecules, and the DNA-binding activity of NF-κB in three pancreatic ductal adenocarcinoma cell lines using BCL10 short hairpin RNA.