PTEN

[Oncogene] Both immunohistochemistry and Western blot assays demonstrated that the expression of PR domain zinc finger protein 4 (PRDM4) in cervical cancer tissues was much lower than that in the normal cervix.

[Oncogene] Researchers discovered that CREB1 played a central role in maintaining new luminal cell survival and that oncogenesis dramatically changed the CREB1-induced transcriptome. CREB1 was active in luminal cells, but not basal cells.

[Journal of Urology] Through genomic profiling of prostate cancer (PCa) across various metastatic sites, scientists identified an extremely low frequency of androgen receptor alterations in pulmonary metastasis without liver involvement PCa, high prevalence of DNA damage response pathway deficiency in hepatic metastasis PCa and high PTEN alteration rates in viscerally-metastatic PCa.

[Cell Death & Disease] Loss of PTEN in fallopian tube epithelium led to the enrichment of CSC markers such as LGR5, WNT4, ALDH1, CD44.

[Cell Death & Disease] Researchers established a library of cancer cell lines that overexpressed mutant proteins using the U87MG and patient-derived cell models lacking functional PTEN.

[Autophagy] Macroautophagy/autophagy plays a critical role in spiral ganglion neurons (SGNs) development, but the effect of autophagy on cisplatin-induced SGN injury is unclear. Scientists found that autophagic flux was activated in SGNs after cisplatin damage.