RAS

[Cancer Letters] Researchers investigated the interaction of ras-related protein in brain (Rab8A) and tropomyosin-related kinase B in regulating the progression of breast cancer. Rab8A was upregulated in breast cancer tissues.

[International Journal of Obesity] Abdominal adipose tissue-derived mesenchymal stem cell were harvested from patients without or with obesity during kidney donation or bariatric surgery, respectively.

[Molecular Cancer Research] Scientists reported a gatekeeper function of the Ras/Erk and NF-κB pathways pathways by working in synergy to suppress liver tumorigenesis.

[Scientific Reports] Gene knockout studies revealed that SOX2 was an essential factor for the generation of CSCs by HRASV12 in mouse and human fibroblasts.

[Scientific Reports] Scientists explored clinical factors in 332 advanced NSCLC who received EGFR TKI and molecular characteristics through 65 whole exome sequencing of various EGFR TKI responses including; de novo, intermediate response and long-term response.

[Cell Death & Disease] Investigators demonstrated the role of oncogenic Ras/syntenin-1 axis in the release of small extracellular vesicles (sEVs) and elucidated the function of syntenin-1-mediated miRNAs in sEVs in lung cancer progression.