RUNX1

[Nature] Scientists created a single-cell transcriptome map of human hematopoietic tissues from the first trimester to birth and found that the hematopoietic stem cell (HSC) signature RUNX1+HOXA9+MLLT3+MECOM+HLF+SPINK2+ distinguished HSCs from progenitors throughout gestation.

[PLoS One] Researchers observed the adverse effects of pentachlorophenol (PCP) on the development of zebrafish by using fluorescence microscopy, and saw that increased concentrations of PCP decreased the numbers of normal red blood cells and myeloid cells.

[Science Advances] Scientists found that global or endothelial-specific loss of all three Tet enzymes immediately after gastrulation led to a reduced number of HSCs and progenitor cells and lethality in mid-gestation mouse embryos.

[Proceedings of the National Academy of Sciences of the United States of America] In NOXA-deficient isogenic cellular models, the authors identified an inhibitor of the transcription factor heterodimer CBFβ/RUNX1.

[Proceedings of the National Academy of Sciences of the United States of America] By genetic gain and loss of function experiments, scientists validated that mode of action dependWS on RUNX1 and NOXA.

[Journal of Proteome Research] The authors performed an in-depth glycosphingolipid (GSL) glycan analysis of 19 AML cell lines using porous graphitized carbon liquid chromatography-mass spectrometry revealing strikingly different GSL glycan profiles between the various AML cell lines.