STAT3

[Cancer Cell International] The authors found that, upon knockdown of DNA Polymerase Theta (POLQ), the proliferation and migration of hepatocellular carcinoma cells decreased and apoptosis percentage increased.

[Science Advances] Investigators indicated that interleukin-11 signaling in endothelial cells antagonized profibrotic transforming growth factor–β signaling and endothelial-to-mesenchymal transition, limiting scarring and promoting cardiomyocyte repopulation, after injury.

[Molecular Cancer Therapeutics] Investigators showed that IL-1α was overexpressed in both murine and human pancreatic ductal adenocarcinomatumors and engaged with its cognate receptor IL-1R1 which was strongly expressed on stromal cells.

[Cancer Cell International] Resveratrol (RES), a naturally occurring phytoalexin, has demonstrated anti-cancer activity in several disease models. The authors describe the STAT3 cascade signaling pathway and address the therapeutic targeting of STAT3 by RES as a tool to mitigate breast cancer.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators identified that coronavirus induced an increased Mφ-mediated inflammatory response due to a coronavirus-induced decrease in the histone methyltransferase, SETDB2.

[American Journal of Chinese Medicine] Researchers investigated the role of puerarin in endoplasmic reticulum stress-associated apoptosis and explore its underlying mechanism in the mouse insulinoma cell line.