Tag Archives: T-cell leukemia

Overexpression of Aberrant Wnt5a and Its Effect on Acquisition of Malignant Phenotypes in Adult T-Cell Leukemia/Lymphoma (ATL) Cells

Scientists demonstrated that the overexpression of c-Myb and FoxM1 was responsible for the synergistic activation of the WNT5A promoter.
[Scientific Reports]
Nakano, K., Chihara, Y., Kobayashi, S., Iwanaga, M., Utsunomiya, A., Watanabe, T., & Uchimaru, K. (2021). Overexpression of aberrant Wnt5a and its effect on acquisition of malignant phenotypes in adult T-cell leukemia/lymphoma (ATL) cells. Scientific Reports, 11(1), 4114. https://doi.org/10.1038/s41598-021-83613-2 Cite
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HTLV-1 Targets Human Placental Trophoblasts in Seropositive Pregnant Women

Investigators found that human T cell leukemia virus type 1 proviral DNA was present in the placental villous tissues of the fetuses of nearly half of pregnant carriers and in a small number of cord blood samples.
[Journal of Clinical Investigation]
Tezuka, K., Fuchi, N., Okuma, K., Tsukiyama, T., Miura, S., Hasegawa, Y., Nagata, A., Komatsu, N., Hasegawa, H., Sasaki, D., Sasaki, E., Mizukami, T., Kuramitsu, M., Matsuoka, S., Yanagihara, K., Miura, K., & Hamaguchi, I. (2020). HTLV-1 targets human placental trophoblasts in seropositive pregnant women. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI135525 Cite
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5-Aminolevulinic Acid-Mediated Photodynamic Therapy Can Target Aggressive Adult T Cell Leukemia/Lymphoma Resistant to Conventional Chemotherapy

With 16 primary blood samples from 13 patients, researchers demonstrated that photodynamic therapy efficiently killed tumor cells without influencing normal lymphocytes in aggressive diseases such as acute adult T cell leukemia/lymphoma.
[Scientific Reports]
Sando, Y., Matsuoka, K., Sumii, Y., Kondo, T., Ikegawa, S., Sugiura, H., Nakamura, M., Iwamoto, M., Meguri, Y., Asada, N., Ennishi, D., Nishimori, H., Fujii, K., Fujii, N., Utsunomiya, A., Oka, T., & Maeda, Y. (2020). 5-aminolevulinic acid-mediated photodynamic therapy can target aggressive adult T cell leukemia/lymphoma resistant to conventional chemotherapy. Scientific Reports, 10(1), 17237. https://doi.org/10.1038/s41598-020-74174-x Cite
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Increased Baseline RASGRP1 Signals Enhance Stem Cell Fitness during Native Hematopoiesis

The authors expanded RASGRP1 expression surveys in pediatric T-ALL and generated a RoLoRiG mouse model crossed to Mx1CRE to determine the consequences of induced RASGRP1 overexpression in primary hematopoietic cells.
[Oncogene]
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GvHD-Free, Relapse-Free Survival Provides Novel Clues for Optimizing Allogeneic-HSCT for Adult T-Cell Leukemia/Lymphoma

The authors performed a nationwide retrospective study of graft-versus-host disease (GvHD)-free, relapse-free survival of patients with allogeneic hematopoietic stem cell transplantation (HSCT)-treated adult T-cell leukemia/lymphoma.
[Bone Marrow Transplantation]
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