T cells

[Nature Reviews Immunology] Scientists review the cells that produce IFNγ and the different effects of IFNγ in the tumor microenvironment, highlighting the pleiotropic nature of this multifunctional and abundant cytokine.

[Environmental Research] The authors investigated the associations between gestational mercury exposure and frequency of cord blood T cells as well as placental gene expression.

[Molecular Imaging and Biology] Scientists used 89Zr-Df-IAB22M2C, a human CD8-specific minibody to monitor CD8+ T cell infiltration into tumors by positron emission tomography.

[Oncogene] Researchers investigated the impact of inhibiting HIF-1α transcriptional activity on cytotoxic immune cell infiltration into B16-F10 melanoma.

[Journal of Hepatocellular Carcinoma] Orthotopic and ectopic hepatocellular carcinoma models were constructed by implanting Hepa1-6 cells at different body sites of mice. Immune agents were administrated via three ways, including intratumoral injection into one site of the tumor, intraperitoneal injection, and subcutaneous injection.

[npj Precision Oncology] Investigators described elevated infiltration by regulatory T cells as the most common feature, while other lymphocyte subsets and also expression of immune-regulatory molecules on tumor-infiltrating lymphocytes showed site-specific variation.