T cells

[Cell] Researchers identified a gene signature defining CAR and TCR dysregulation and transcription factors, including SOX4 and ID3 as key regulators of CAR T cell exhaustion.

[Blood] Scientists identified PR domain zinc finger protein 1 (PRDM1) i.e., Blimp-1, as a key epigenetic gene associated with terminal T cell differentiation.

[Science Immunology] Researchers showed that SOCS1 was a critical node integrating both IL-2 and IFN-γ signals to block multiple downstream signaling pathways abrogating CD4+ T helper 1 (TH1) cell response.

[Nature Biomedical Engineering] The authors showed that T cell-mediated cancer-cell killing was hampered for cortically soft cancer cells, which have plasma membranes enriched in cholesterol.

[Cell Reports] Investigators used flow cytometry, T cell receptor sequencing, single-cell transcriptomics, and cytokine analysis to profile virus-specific CD8+ T cells recognizing the ubiquitous pathogens influenza and cytomegalovirus.

[Cell] The authors immunized rhesus macaques and assessed immune responses over one year in blood, upper and lower airways.