TRPV4

[Acta Pharmacologica Sinica] The authors showed that interrupting TRPV4–Nox2 coupling by TRPV4 knockout, or by treatment with a specific Nox2 inhibitor Nox2 dstat or a specific TRPV4 inhibitor HC067046 significantly attenuated obesity-induced ROS overproduction in aortic endothelial cells, and reversed the abnormal endothelial cytoskeletal structure.

[Journal of Cellular and Molecular Medicine] The authors found that the secretome obtained by human amniotic fluid-derived stem cells undergoing hypoxic preconditioning induced intracellular Ca2+ oscillations by promoting extracellular Ca2+ entry through Transient Receptor Potential Vanilloid 4.

[Proceedings of the National Academy of Sciences of the United States of America] Investigators demonstrated that mouse microglia exhibited temperature-dependent movement in vitro and in vivo that was mediated by TRPV4 channels within the physiological range of body temperature.

[Laboratory Investigation] The authors investigated the role of Transient Receptor Potential Vanilloid 4 in 5-HT-induced plasma extravasation using pharmacological and genetic approaches.

[Science Signaling] The authors studied the effects of the proinflammatory cytokine TNFα on transendothelial permeability and electrophysiology in ex vivo murine veins and arteries.

[Autophagy] Researchers investigated the molecular mechanisms underlying the antitumor effect of cannabidiol in preclinical models of human glioma.