YAP

[Biochemical and Biophysical Research Communications] Scientists found that the expression level of YAP/TAZ in tamoxifen-resistant MCF7 breast cancer cells was significantly increased compared with that in MCF7 cells.

[Journal of Biological Chemistry] The authors found that a molecule designated GA-017 increased the number and size of spheroids of various cell-types in both scaffold-based and scaffold-independent cultures.

[Circulation Research] Mouse models of atherosclerosis in endothelial cell-specific-Bach1 knockout mice were used to study the role of BTB and CNC homology 1 (BACH1) in the regulation of atherogenesis and the underlying mechanisms.

[Pharmacological Research] Scientists found that fibroblast growth factor 18 was markedly upregulated in carbon tetrachloride-induced fibrotic mouse liver tissues and transforming growth factor β stimulated LX-2 cells.

[Molecular Cancer Research] To discover new neuroblastoma therapies, investigators utilized the Connectivity Map to identify compounds that could reverse the metastatic transcriptional signature and found calcipotriol, a Vitamin D3 analog, to be a compound that selectively targets cell lines with enhanced metastatic potential.

[Nature Communications] The authors suggested that KIRREL1 functioned as a feedback regulator of the mammalian Hippo pathway through sensing cell-cell interaction and recruiting SAV1 to cell-cell contact sites.