adipocytes

[Molecular Therapy-Nucleic Acids] The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.

[Stem Cell Research & Therapy] Investigators constructed PRL-1 overexpressed human placental mesenchymal stem cells in an attempt to enhance the suppressive function of adipogenesis in Graves’ ophthalmopathy animal models.

[Communications Biology] The authors fate mapped the leptin receptor-expressing (LepR+) MSCs in different embryonic and adult extremities using Lepr-cre; tdTomato mice and investigated the underling mechanism using Lepr-cre; Ppp2r1afl/fl mice.

[iScience] Prompted by findings in patient biopsies, scientists used the model to investigate the role of platelets in malignant cell invasion and ECM production.

[Nature Communications] Scientists found that the liver primarily controlled the circulating levels of soluble FNDC4 (sFNDC4) and lowering of the hepatokine FNDC4 led to prediabetes in mice.

[Nature Metabolism] Researchers identified an endocrine pathway regulated by Uncoupling protein 1 (UCP1) that antagonizes liver inflammation and pathology, independent of effects on obesity.