astrocytes

[Cell Reports] Scientists assessed medial prefrontal cortex and visual cortex astrocyte and whole-tissue gene expression changes in mice following peripherally induced neuroinflammation triggered by a systemic bacterial endotoxin, lipopolysaccharide, which produced sickness-related behaviors, including anhedonia.

[Cell Metabolism] The paradigm of this biological feature is the astrocyte-neuron couple, in which the glycolytic metabolism of astrocytes contrasts with the mitochondrial oxidative activity of neurons.

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

[Nature Communications] Investigators generated sensorimotor organoids containing physiologically functional neuromuscular junctions and applied the model to different subgroups of amyotrophic lateral sclerosis.

[Advanced Science] Serum-exposed brain organoids are able to recapitulate Alzheimer's disease-like pathologies, including increased amyloid beta aggregates and phosphorylated microtubule-associated tau protein level, synaptic loss, and impaired neural network.

[Cell Death & Disease] Researchers showed that α-synuclein preformed fibrils induced pathogenic activation of human midbrain astrocytes, marked by inflammatory transcriptional responses, downregulation of phagocytic function, and conferral of neurotoxic activity.