astrocytes

[Cell Death Discovery] With various stimulus, chances for neural stem cells (NSCs) to differentiate into neurons, astrocytes, oligodendrocytes are great and is considered as a potential source of the stem cell therapy to SCI. Scientists used adeno-associated virus to carry the target gene to transfect NSCs.

[Translational Psychiatry] Scientists found that bilobalide inhibited Aβ-induced and STAT3-dependent expression of TNF-α, IL-1β, and IL-6 in primary astrocyte culture.

[Cell Death & Disease] Scientists provided an integrative analysis of cellular metabolism during the early stages of amyloid-β accumulation in the cerebral cortex and hippocampus of the 5xFAD mouse model of Alzheimer’s disease.

[Clinical Cancer Research] Four patient-derived xenografts, two patient-derived organoi and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of 6-thio-2'-deoxyguanosine.

[Cell Death & Disease] Researchers found that YAP was upregulated and activated in astrocytes of spinal cords of encephalomyelitis mice through suppression of the Hippo pathway.

[EMBO Reports] The authors showed that secreted frizzled-related protein 1 (SFRP1), a multifunctional regulator of cell-to-cell communication, was part of the cellular crosstalk underlying neuroinflammation.