breast cancer cells

[iScience] Researchers examined the significance of olfactory receptor (OR) transcript abundance in primary and metastatic breast cancer to the brain, bone, and lung. Knockdown of OR5B21 significantly decreased the invasion and migration of breast cancer cells as well as metastasis to different organs.

[Cell Death & Disease] Scientists compared the effects of cancer-associated fibroblasts (CAFs)-derived exosomes and normal fibroblasts (NFs)-derived exosomes on breast cancer cells migration and invasion and showed that CAFs-derived exosomes had a more enhancing effect on breast cancer cells migration and invasion than NFs-derived exosomes.

[Acta Pharmacologica Sinica] Investigators demonstrated that organic anion transporting polypeptide and endocytosis synergistically drove the uptake of the farnesylthiosalicylic acid-IR783 conjugate in breast cancer MDA-MB-231 cells, resulting in superior tumor-targeting ability of the conjugate both in vitro and in vivo.

[Scientific Reports] The authors characterized the anticancer activity of the A. testudineus antimicrobial peptides, which were synthetically produced and subjected to cytotoxic assay to prove their efficacy against cancer cell lines.

[Bioengineered] Researchers found high TSPAN1 expression in breast cancer tumor samples and cell lines which was confirmed by bioinformation analysis. The ablation of TSPAN1 suppressed the growth, and motility of breast cancer cells and affected the epithelial-mesenchymal transition in breast cancer cells.

[Oncogene] The authors showed that TMEM201, as a positive modulator, was both necessary and sufficient to regulate the migration and invasion of breast cancer cells in vitro and in vivo.