breast cancer cells

[Cell] Scientists showed that nuclear envelope ruptures induced DNA damage that promoted senescence in non-transformed cells and induced an invasive phenotype in human breast cancer cells.

[EMBO Journal] Investigators showed that the novel oncogene RASSF1C drove mesenchymal-to-amoeboid transition and stem cell attributes in breast cancer cells. Mechanistically, RASSF1C activated Rho/ROCK via SRC-mediated RhoGDI inhibition, resulting in generation of actomyosin contractility.

[npj Breast Cancer] From in vitro and in vivo studies, scientists concluded that Iminodibenzyl could reprogram COX-2 induced DGLA peroxidation to produce anti-cancer activity.

[Frontiers in Immunology] Investigators enriched ubiquitinated proteins (UPs) from epirubicin (EPB)-induced multi-drug-resistant cancer stem-like breast cancer cell line and tested the efficacy of α-Al2O3-UPs-4T1/EPB as therapeutic vaccine alone and in combination with the stimulator of interferon genes (STING) agonist in mice with drug-resistant and metastatic breast cancer.

[Cell Biochemistry and Function] The authors provide an overview of the key growth factors that trigger breast cancer angiogenesis.

[Cell Death & Disease] In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.