EMP3 Negatively Modulates Breast Cancer Cell DNA Replication, DNA Damage Repair, and Stem-Like Properties

In silico analysis showed that epithelial membrane protein 3 (EMP3) was associated with favorable survival, and negatively regulated cell cycle S-phase. Loss and gain of function studies demonstrated that EMP3 inhibited breast cancer cell S-phage entry, DNA replication, DNA damage repair, and stem-like properties.