Anti-Estrogenic and Anti-Aromatase Activities of Citrus Peels Major Compounds in Breast Cancer

The authors investigated the antitumor potential of the most potent compounds in citrus peels on breast cancer by exploring their anti-estrogenic and anti-aromatase activities.
[Scientific Reports]
El-Kersh, D. M., Ezzat, S. M., Salama, M. M., Mahrous, E. A., Attia, Y. M., Ahmed, M. S., & Elmazar, M. M. (2021). Anti-estrogenic and anti-aromatase activities of citrus peels major compounds in breast cancer. Scientific Reports, 11(1), 7121. https://doi.org/10.1038/s41598-021-86599-z Cite
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Colon Epithelial Cell TGFβ Signaling Modulates the Expression of Tight Junction Proteins and Barrier Function in Mice

In vitro colon organoid culture was utilized to assess junction-related gene expression by qPCR and trans-epithelial resistance. In silico analyses of human inflammatory bowel disease and colon cancer databases were performed.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
Marincola Smith, P., Choksi, Y. A., Markham, N. O., Hanna, D. N., Zi, J., Weaver, C. J., Hamaamen, J. A., Lewis, K. B., Yang, J., Liu, Q., Kaji, I., Means, A. L., & Beauchamp, R. D. (2021). Colon epithelial cell TGFβ signaling modulates the expression of tight junction proteins and barrier function in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology. https://doi.org/10.1152/ajpgi.00053.2021 Cite
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Computational and Experimental Characterization of the Novel ECM Glycoprotein SNED1 and Prediction of its Interactome

Pathway analysis of the predicted SNED1 interactome further revealed that it may contribute to signaling through cell surface receptors, such as integrins, and participate in the regulation of ECM organization and developmental processes.
[Biochemical Journal]
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CASC11 Promotes Aggressiveness of Prostate Cancer Cells through miR-145/IGF1R Axis

The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.
[Prostate Cancer and Prostatic Diseases]
Capik, O., Sanli, F., Kurt, A., Ceylan, O., Suer, I., Kaya, M., Ittmann, M., & Karatas, O. F. (2021). CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis. Prostate Cancer and Prostatic Diseases, 1–12. https://doi.org/10.1038/s41391-021-00353-0 Cite
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Bone Marrow‐Derived Mesenchymal Stem Cells Improve Rat Islet Graft Revascularization by Upregulating ISL1

Researchers identified the insulin gene enhancer binding protein‐1 (ISL-1) protein as a potential modulator in bone marrow‐derived mesenchymal stem cell (BMSC)‐mediated revascularization of islet grafts. They demonstrated that the survival rate and insulin secretion of islets were increased in the presence of BMSCs, indicating that BMSCs promoted islet revascularization in a coculture system and rat diabetes model.
[Stem Cells]
Wang, Y., Wang, J.-W., Li, Y., Tian, X.-H., Feng, X.-S., Zhang, S.-C., Liu, P.-J., Xue, W.-J., Zheng, J., & Ding, X.-M. (n.d.). Bone marrow-derived mesenchymal stem cells improve rat islet graft revascularization by upregulating ISL1. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3378 Cite
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Circulating Mucosal-Associated Invariant T Cells Identify Patients Responding to Anti-PD-1 Therapy

Scientists combined single-cell RNA-sequencing and multiparameter flow cytometry to assess changes in circulating CD8+ T cells in 28 patients with metastatic melanoma starting anti-PD-1 therapy.
[Nature Communications]
De Biasi, S., Gibellini, L., Lo Tartaro, D., Puccio, S., Rabacchi, C., Mazza, E. M. C., Brummelman, J., Williams, B., Kaihara, K., Forcato, M., Bicciato, S., Pinti, M., Depenni, R., Sabbatini, R., Longo, C., Dominici, M., Pellacani, G., Lugli, E., & Cossarizza, A. (2021). Circulating mucosal-associated invariant T cells identify patients responding to anti-PD-1 therapy. Nature Communications, 12(1), 1669. https://doi.org/10.1038/s41467-021-21928-4 Cite
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All-Trans Retinoic Acid and Protein Kinase C α/β1 Inhibitor Combined Treatment Targets Cancer Stem Cells and Impairs Breast Tumor Progression

Employing hormone-independent mammary cancer models, Gö6976 and all-trans-retinoic acid combined treatment induced a synergistic reduction in proliferative potential that correlated with an increased apoptosis and RARs modulation towards an anti-oncogenic profile.
[Scientific Reports]
Berardi, D. E., Ariza Bareño, L., Amigo, N., Cañonero, L., Pelagatti, M. de las N., Motter, A. N., Taruselli, M. A., Díaz Bessone, M. I., Cirigliano, S. M., Edelstein, A., Peters, M. G., Diament, M., Urtreger, A. J., & Todaro, L. B. (2021). All-trans retinoic acid and protein kinase C α/β1 inhibitor combined treatment targets cancer stem cells and impairs breast tumor progression. Scientific Reports, 11(1), 6044. https://doi.org/10.1038/s41598-021-85344-w Cite
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GLIPR1 and SPARC Expression Profile Reveals a Signature Associated with Prostate Cancer Brain Metastasis

Researchers analyzed the molecular profile, as well as the functional consequences involved in the reciprocal interactions between prostate tumor cells and human astrocytes.
[Molecular and Cellular Endocrinology]
Gouvêa de Oliveira Barros, E., Branco, L. C., Da Costa, N. M., Neto, P. N., Palmero, C., Pontes, B., Ferreira do Amaral, R., Alves-Leon, S. V., Marcondes de Souza, J., Romão, L., Fernandes, P. V., Martins, I., Takiya, C., Ribeiro Pinto, L. F., Palumbo, A., & Nasciutti, L. E. (2021). GLIPR1 and SPARC Expression Profile Reveals a Signature Associated with Prostate Cancer Brain Metastasis. Molecular and Cellular Endocrinology, 111230. https://doi.org/10.1016/j.mce.2021.111230 Cite
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TGFβ/Cyclin D1/Smad-Mediated Inhibition of BMP4 Promotes Breast Cancer Stem Cell Self-Renewal Activity

Investigators investigated the interplay and networking pathways occurring between TGFβ family ligands in regulating stemness in triple negative breast cancer (TNBC). They found that TGFβ stimulation of TNBCs resulted in enhanced tumorsphere formation efficiency and an increased proportion of the highly tumorigenic CD44high/CD24low cancer stem cell population.
[Oncogenesis]
Yan, G., Dai, M., Zhang, C., Poulet, S., Moamer, A., Wang, N., Boudreault, J., Ali, S., & Lebrun, J.-J. (2021). TGFβ/cyclin D1/Smad-mediated inhibition of BMP4 promotes breast cancer stem cell self-renewal activity. Oncogenesis, 10(3), 1–14. https://doi.org/10.1038/s41389-021-00310-5 Cite
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Single-Cell Transcriptomic Profiling and Characterization of Endothelial Progenitor Cells: New Approach for Finding Novel Markers

Scientists assembled five groups of chosen endothelial progenitor cells (EPCs)-related genes/factors using PubMed literature and Gene Ontology databases. This shortened database of EPC factors was fed into publically published transcriptome matrix to compare their expression between endothelial colony-forming cells, HUVECs, and two adult endothelial cell types from the skin and adipose tissue.
[Stem Cell Research & Therapy]
Abdelgawad, M. E., Desterke, C., Uzan, G., & Naserian, S. (2021). Single-cell transcriptomic profiling and characterization of endothelial progenitor cells: new approach for finding novel markers. Stem Cell Research & Therapy, 12(1), 145. https://doi.org/10.1186/s13287-021-02185-0 Cite
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Optogenetic Current in Myofibroblasts Acutely Alters Electrophysiology and Conduction of Co-Cultured Cardiomyocytes

Cardiac myofibroblasts were transduced with Channelrhodopsin-2, which allowed acute and selective increase of myofibroblast current, and plated on top of cardiomyocytes.
[Scientific Reports]
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