TGFBI Modulates Tumor Hypoxia and Promotes Breast Cancer Metastasis

Researchers crossed the MMTV‐PyMT model of mammary gland tumorigenesis with a TgfbiΔ/Δ mouse, and studied the cancer stem cell (CSC) content of the tumors. They performed RNAseq on WT and KO tumours, and analyzed the tumor vasculature and the immune compartment by IHC and FACS.
[Molecular Oncology]
Fico, F., & Santamaria‐Martínez, A. (n.d.). TGFBI modulates tumour hypoxia and promotes breast cancer metastasis. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12828 Cite
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EVI1 Phosphorylation at S436 Regulates Interactions with CtBP1 and DNMT3A and Promotes Self-Renewal

Wild-type EVI1 with S436 available for phosphorylation, but not non-phosphorylatable EVI1-S436A, conferred hematopoietic progenitor cell self-renewal and was associated with significantly higher organized transcriptional patterns.
[Cell Death & Disease]
Paredes, R., Kelly, J. R., Geary, B., Almarzouq, B., Schneider, M., Pearson, S., Narayanan, P., Williamson, A., Lovell, S. C., Wiseman, D. H., Chadwick, J. A., Jones, N. J., Kustikova, O., Schambach, A., Garner, T., Amaral, F. M. R., Pierce, A., Stevens, A., Somervaille, T. C. P., … Meyer, S. (2020). EVI1 phosphorylation at S436 regulates interactions with CtBP1 and DNMT3A and promotes self-renewal. Cell Death & Disease, 11(10), 1–14. https://doi.org/10.1038/s41419-020-03099-0 Cite
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Inherited Causes of Clonal Haematopoiesis in 97,691 Whole Genomes

In silico-informed in vitro evaluation of the TET2 germline locus enabled the identification of a causal variant that disrupted a TET2 distal enhancer, resulting in increased self-renewal of hematopoietic stem cells.
[Nature]
Bick, A. G., Weinstock, J. S., Nandakumar, S. K., Fulco, C. P., Bao, E. L., Zekavat, S. M., Szeto, M. D., Liao, X., Leventhal, M. J., Nasser, J., Chang, K., Laurie, C., Burugula, B. B., Gibson, C. J., Lin, A. E., Taub, M. A., Aguet, F., Ardlie, K., Mitchell, B. D., … Natarajan, P. (2020). Inherited causes of clonal haematopoiesis in 97,691 whole genomes. Nature, 1–7. https://doi.org/10.1038/s41586-020-2819-2 Cite
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EZH2 Regulates Expression of FOXC1 by Mediating H3K27me3 in Breast Cancers

Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Zheng, X., Li, W., Yi, J., Liu, J., Ren, L., Zhu, X., Liu, S., Wang, J., & Du, G. (2020). EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-00543-x Cite
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Nicotinamide Inhibits Melanoma In Vitro and In Vivo

The anti-melanoma activity of Nicotinamide, the amide form of Niacin, was assessed in vitro and in vivo.
[Journal of Experimental & Clinical Cancer Research]
Scatozza, F., Moschella, F., D’Arcangelo, D., Rossi, S., Tabolacci, C., Giampietri, C., Proietti, E., Facchiano, F., & Facchiano, A. (2020). Nicotinamide inhibits melanoma in vitro and in vivo. Journal of Experimental & Clinical Cancer Research, 39(1), 211. https://doi.org/10.1186/s13046-020-01719-3 Cite
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Fibroblast Growth Factor Receptor 3 Activates a Network of Profibrotic Signaling Pathways to Promote Fibrosis in Systemic Sclerosis

Investigators demonstrated that the profibrotic cytokine transforming growth factor β selectively up-regulated fibroblast growth factor receptor 3 (FGFR3) and its ligand FGF9 to promote fibroblast activation and tissue fibrosis, leading to a prominent FGFR3 signature in the systemic sclerosis skin.
Chakraborty, D., Zhu, H., Jüngel, A., Summa, L., Li, Y.-N., Matei, A.-E., Zhou, X., Huang, J., Trinh-Minh, T., Chen, C.-W., Lafyatis, R., Dees, C., Bergmann, C., Soare, A., Luo, H., Ramming, A., Schett, G., Distler, O., & Distler, J. H. W. (2020). Fibroblast growth factor receptor 3 activates a network of profibrotic signaling pathways to promote fibrosis in systemic sclerosis. Science Translational Medicine, 12(563). https://doi.org/10.1126/scitranslmed.aaz5506 Cite
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Designing a Multi-Epitope Peptide Based Vaccine against SARS-CoV-2

Researchers mapped immunogenic epitopes present on the four structural proteins of SARS-CoV-2 and we designed a multi-epitope peptide based vaccine that, demonstrated a high immunogenic response with a vast application on world’s human population.
[Scientific Reports]
Designing a multi-epitope peptide based vaccine against SARS-CoV-2 | Scientific Reports. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41598-020-73371-y Cite
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A Functional Genomic Screen Identifies the Deubiquitinase USP11 as a Novel Transcriptional Regulator of ERα in Breast Cancer

Scientists investigated the role of deubiquitinases (DUB) in regulating estrogen receptor α (ERα) in breast cancer. An RNAi loss-of-function screen in breast cancer cells targeting all DUB identified USP11 was a regulator of ERα transcriptional activity, which was further validated by assessment of direct transcriptional targets of ERα.
[Cancer Research]
Dwane, L., O’Connor, A. E., Das, S., Moran, B., Mulrane, L., Pinto-Fernandez, A., Ward, E., Blümel, A. M., Cavanagh, B. L., Mooney, B., Dirac, A. M., Jirström, K., Kessler, B. M., Chonghaile, T. N., Bernards, R., Gallagher, W. M., & O’Connor, D. P. (2020). A functional genomic screen identifies the deubiquitinase USP11 as a novel transcriptional regulator of ERα in breast cancer. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-0214 Cite
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Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner

Scientists recognized the tumor suppressor gene Phosphatase and Tensin homolog (PTEN) as a potential gene causing CIN in TNBC and showed that TNBC with low expression levels of PTEN can be sensitized for the treatment with poly-(ADP-ribose)-polymerase 1 (PARP1) inhibitors, independent of Breast Cancer (BRCA) mutations or a BRCA-like phenotype.
[Cancers]
Rieckhoff, J., Meyer, F., Classen, S., Zielinski, A., Riepen, B., Wikman, H., Petersen, C., Rothkamm, K., Borgmann, K., & Parplys, A. C. (2020). Exploiting Chromosomal Instability of PTEN-Deficient Triple-Negative Breast Cancer Cell Lines for the Sensitization against PARP1 Inhibition in a Replication-Dependent Manner. Cancers, 12(10), 2809. https://doi.org/10.3390/cancers12102809 Cite
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CSPG4-Specific CAR.CIK Lymphocytes as a Novel Therapy for the Treatment of Multiple Soft Tissue Sarcoma Histotypes

The functional activity of chondroitin sulfate proteoglycan 4 (CSPG4)-CAR-redirected cytokine-induced killer lymphocytes (CAR.CIK) was explored in vitro, in 2D and 3D soft tissue sarcoma (STS) cultures, and in three in vivo STS xenograft models.
[Clinical Cancer Research]
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Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer

Scientists showed that the VAV2-regulated stem cell-like program harbored a number of cell cycle- and signaling-related kinases that were essential for the viability of undifferentiated keratinocytes and head and neck squamous cell carcinomapatient-derived cells endowed with high levels of VAV2 activity.
[Cancers]
Lorenzo-Martín, L. F., Menacho-Márquez, M., & Bustelo, X. R. (2020). Drug Vulnerabilities and Disease Prognosis Linked to the Stem Cell-Like Gene Expression Program Triggered by the RHO GTPase Activator VAV2 in Hyperplastic Keratinocytes and Head and Neck Cancer. Cancers, 12(9), 2498. https://doi.org/10.3390/cancers12092498 Cite
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