Integrated Systems-Analysis of the Murine and Human Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

Researchers observed both common and distinct patterns of glycosylation in pancreatic cancer across species. Common alterations included increased levels of α-2,3- and α-2,6-sialic acids, bisecting GlcNAc and poly-LacNAc.
[Molecular & Cellular Proteomics]
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The Role of miRNAs 340-5p, 92a-3p, and 381-3p in Patients with Endometriosis: A Plasma and Mesenchymal Stem-Like Cell Study

Peripheral blood and endometrial (e)MSC specimens were collected from suspected women of endometriosis before laparoscopy. Total RNA was isolated from plasma and cultured eMSCs to synthesize complementary DNA.
[Biomed Research International]
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Clinical Evolution, Genetic Landscape and Trajectories of Clonal Hematopoiesis in SAMD9/SAMD9L Syndromes

The authors investigated a clinically annotated pediatric myelodysplastic syndromes cohort to define the prevalence, genetic landscape, phenotype, therapy outcome and clonal architecture of SAMD9/9L syndromes.
[Nature Medicine]
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Discovery of a New Candidate Drug to Overcome Cabazitaxel-Resistant Gene Signature in Castration-Resistant Prostate Cancer by In Silico Screening

Researchers used screening tests for candidate drugs targeting cabazitaxel (CBZ)-resistant-related gene expression and identified pimozide as a potential candidate for overcoming CBZ resistance in castration-resistant prostate cancer.
[Prostate Cancer and Prostatic Diseases]
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Identification of HMGCR as the Anticancer Target of Physapubenolide against Melanoma Cells by In Silico Target Prediction

Scientists demonstrated that physapubenolide (PB) inhibited cell proliferation and migration in melanoma cells by inducing cell apoptosis. They explored the mechanism underlying the anticancer effects of PB through an in silico target prediction study.
[Acta Pharmaceutica Sinica B]
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Oxysterol Binding Protein-Like 3 (OSBPL3) Is a Novel Driver Gene That Promotes Tumor Growth in Part through R-Ras/Akt Signaling in Gastric Cancer

Gastric cancer (GC) is one of the most lethal malignant tumors. Researchers identified novel driver genes and clarified their roles in GC.
[Scientific Reports]
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Rutin Inhibited the Advanced Glycation End Products-Stimulated Inflammatory Response and Extracellular Matrix Degeneration via Targeting TRAF-6 and BCL-2 Proteins in Mouse Model of Osteoarthritis

Scientists screened rutin (RT) for its activity against osteoarthritis with in vivo and in vitro models of osteoarthritis. Pretreatment of RT decreased the ECM degradation, inhibited expression of TRAF-6 and BCL-2 the NF-κB/MAPK pathway proteins.
[Aging]
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SNAI1-Mediated Transcriptional Regulation of Epithelial-to-Mesenchymal Transition Genes in Breast Cancer Stem Cells

Researchers performed in silico analysis of microarray data from luminal, Her2+, and triple-negative breast cancer cell lines and identified 15 relatively unexplored epithelial-to-mesenchymal (EMT)-related differentially expressed genes along with the markedly high expression of EMT-transcription factor, SNAI1.
[Cellular Signalling]
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Targeting the Actin Nucleation Promoting Factor WASp Provides a Therapeutic Approach for Hematopoietic Malignancies

Since Wiskott–Aldrich Syndrome protein (WASp) is exclusively expressed in hematopoietic cells, scientists performed in silico screening to identify small molecule compounds that bound WASp and promoted its degradation.
[Nature Communications]
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In Vitro and In Silico Studies of Holothurin a on Androgen Receptor in Prostate Cancer

Scientists investigated the potential of using a marine triterpenoid saponin, holothurin A, on targeting androgen receptor expression of prostate cancer using in vitro and in silico studies.
[Journal of Biomolecular Structure and Dynamics]
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MicroRNA-26a/B-5p Promotes Myocardial Infarction-Induced Cell Death by Downregulating Cytochrome C Oxidase 5a

Researchers found that cytochrome c oxidase subunit 5a expression was noticeably decreased in myocardial infarcted rat hearts and myocardial cells under hypoxic conditions, regulated other identified proteins and was closely related to hypoxia-induced cell death.
[Experimental and Molecular Medicine]
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