Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.
[Biomedicine & Pharmacotherapy]
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Urine Peptidome in Combination with Transcriptomics Analysis Highlights MMP7, MMP14 and PCSK5 for Further Investigation in Chronic Kidney Disease

Through investigating chronic kidney disease-associated transcriptomics datasets, several proteases were highlighted including members of matrix metalloproteinases and serine proteases.
[PLoS One]
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MiR-423-5p Prevents MALAT1-Mediated Proliferation and Metastasis in Prostate Cancer

Using lentiviral stable miRNA transfection together with cell biology functional assays and gene expression/target analysis, scientists investigated the interaction between MALAT1 and miR-423-5p, defined as a target with in silico prediction analysis, in prostate cancer.
[Journal of Experimental & Clinical Cancer Research]
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Methylation-Mediated Silencing of Protein Kinase C Zeta Induces Apoptosis Avoidance through ATM/CHK2 Inactivation in Dedifferentiated Chondrosarcoma

Researchers identified genes downregulated in dedifferentiated chondrosarcoma vs. conventional chondrosarcoma due to DNA methylation using in silico analysis.
[British Journal of Cancer]
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Pediatric Brain Tumor Cell Lines Exhibit miRNA-Depleted, Y RNA-Enriched Extracellular Vesicles

Scientists isolated extracellular vesicles from medulloblastoma and diffuse infiltrative pontine glioma patient-derived cell lines and explored the small ncRNA transcriptome.
[Journal of Neuro-Oncology]
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FGFR Blockade by Pemigatinib Treats Naïve and Castration Resistant Prostate Cancer

Investigators validated the therapeutic efficacy the FDA-approved FGFR inhibitor pemigatinib, in an integrated platform consisting of human and murine prostate cancer (PCa) cells, and the transgenic multistage TRAMP model of PCa that recapitulated both androgen-dependent and CRPC settings.
[Cancer Letters]
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AMPK Modulation Ameliorates Dominant Disease Phenotypes of CTRP5 Variant in Retinal Degeneration

In iPSC-derived retinal pigment epithelium from late-onset retinal degeneration patients, researchers showed that the dominant pathogenic CTRP5 variant led to reduced CTRP5 secretion.
[Communications Biology]
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Fibroblast-Mediated Intercellular Crosstalk in the Healthy and Diseased Heart

The authors review the current knowledge of fibroblast interactions in the healthy, diseased and aging heart.
[Febs Letters]
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Combination of Resveratrol and BIBR1532 Inhibits Proliferation of Colon Cancer Cells by Repressing Expression of LncRNAs

Scientists investigated the effect of resveratrol and BIBR1532, either alone or in combination, on the cell viability as well as on expression of long non-coding RNAs for HT-29 colon adenocarcinoma cells.
[Medical Oncology]
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Topoisomerase II Alpha Inhibition Can Overcome Taxane-Resistant Prostate Cancer through DNA Repair Pathways

Cabazitaxel (CBZ) was approved for the treatment of docetaxel-resistant castration-resistant prostate cancer (CRPC). Researchers explored the optimal treatment for CRPC in the post-cabazitaxel setting using PC3 (CBZ-sensitive) and PC3CR cells (CBZ-resistant).
[Scientific Reports]
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Chemogenetic Modulation of Sensory Neurons Reveals Their Regulating Role in Melanoma Progression

Whether sensory neuronal activity is important for tumor progression remains unknown. Researchers suggested that sensory innervations regulate melanoma progression, indicating that manipulation of sensory neurons’ activity may provide a valuable tool to improve melanoma patients’ outcomes.
[Acta Neuropathologica Communications]
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