Among 759 specimens, immunohistochemistry exhibited glycoprotein non-metastatic B (GPNMB) expressions were variable in different subtypes and significantly higher in TNBC. GPNMB positively correlated with epithelial–mesenchymal transition regulators, mesenchymal marker vimentin, MMP and integrins.
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The exaggerated images unveiled pseudopodial extensions and increased light scattering as hallmark properties of metastatic cells. Scientists validated this interpretation using live cells spontaneously transitioning between states indicative of low and high metastatic efficiency.
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Zaritsky, A., Jamieson, A. R., Welf, E. S., Nevarez, A., Cillay, J., Eskiocak, U., Cantarel, B. L., & Danuser, G. (2021). Interpretable deep learning uncovers cellular properties in label-free live cell images that are predictive of highly metastatic melanoma. Cell Systems, 0(0). https://doi.org/10.1016/j.cels.2021.05.003 Cite
Researchers delineated the phenotypic and functional defects in NK cells of high-risk B- and T- cell acute lymphoblastic leukemia (ALL) patients using mass, flow, and in silico cytometry, with the goal of further elucidating the role of NK cells in sustaining ALL regression.
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Duault, C., Kumar, A., Taghi Khani, A., Lee, S. J., Yang, L., Huang, M., Hurtz, C., Manning, B., Ghoda, L. Y., McDonald, T., Lacayo, N. J., Sakamoto, K. M., Carroll, M. P., Tasian, S. K., Marcucci, G., Yu, J., Caligiuri, M. A., Maecker, H. T., & Swaminathan, S. (2021). Activated Natural Killer Cells Predict Poor Clinical Prognosis in High-risk B- and T- cell Acute Lymphoblastic Leukemia. Blood, blood.2020009871. https://doi.org/10.1182/blood.2020009871 Cite
The authors investigated the signaling pathways through which ONC201/CHOP crosstalk was regulated in ONC201-treated nonmetastatic and metastatic colorectal cancer cell lines.
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The authors hypothesized that divergent infection outcomes were a natural result of mutual negative feedbacks between pathogens and the host immune response.
[Proceedings of the Royal Society B-Biological Sciences]
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Investigators present SFRP2 as a SOX2-antagonist with the capacity to induce a mesenchymal subtype transition in glioma cells located in vascular tumor areas, highlighting its role in glioblastoma tumor evolution and intratumoral heterogeneity.
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Linear, adhered rat and human 3D neuronal-astrocyte cultures were developed to enable the study of aggregation and sorting of these cells. An in silico model of the contraction, clustering, and cell sorting in the 3D cultures was also developed.
Scientists identify key regulatory pathways that distinguish the liver and lung tumor microenvironments in a preclinical mouse model of metastatic pancreatic ductal adenocarcinoma.
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Cryopreserved hepatocytes from humans, rats, and rainbow trout were used to measure CLint values for 54 industrial and pesticidal chemicals at starting test concentrations of 0.1 and 1 µM.
Induced pluripotent stem cell-derived endothelial cells generated from six patients with pulmonary arterial hypertension were exposed to 4500 compounds and assayed for improved cell survival after serum withdrawal using a chemiluminescent caspase assay.
[Science Translational Medicine]
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Gu, M., Donato, M., Guo, M., Wary, N., Miao, Y., Mao, S., Saito, T., Otsuki, S., Wang, L., Harper, R. L., Sa, S., Khatri, P., & Rabinovitch, M. (2021). iPSC–endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension. Science Translational Medicine, 13(592). https://doi.org/10.1126/scitranslmed.aba6480 Cite
Scientists found that LAMP5 is a direct target of the oncogenic MLL-fusion protein. LAMP5 depletion significantly inhibited leukemia cell growth in vitro and in vivo.
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Gracia-Maldonado, G., Clark, J., Burwinkel, M., Greenslade, B., Wunderlich, M., Salomonis, N., Leone, D., Gatti, E., Pierre, P., Kumar, A. R., & Lee, L. H. (2020). LAMP-5 is an essential inflammatory-signaling regulator and novel immunotherapy target for Mixed Lineage Leukemia-Rearranged acute leukemia. Haematologica. https://doi.org/10.3324/haematol.2020.257451 Cite