Tag Archives: MTOR

Propofol Inhibits Tumor Angiogenesis through Targeting VEGF/VEGFR and mTOR/eIF4E Signaling

Investigators showed that propofol inhibited tubular structure formation of both lung cancer associated endothelial cells and colon cancer associated endothelial cells, particularly the early stages of angiogenesis.
[Biochemical and Biophysical Research Communications]
Wang, Z., Cao, B., Ji, P., & Yao, F. (2021). Propofol inhibits tumor angiogenesis through targeting VEGF/VEGFR and mTOR/eIF4E signaling. Biochemical and Biophysical Research Communications, 555, 13–18. https://doi.org/10.1016/j.bbrc.2021.03.094 Cite
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Metabolic Modulation by CDK4/6 Inhibitor Promotes Chemokine-Mediated Recruitment of T Cells Into Mammary Tumors

Investigators showed that cyclin-dependent kinases 4 and 6 (CDK4/6i) could enhance efficacy of T cell-based therapies, such as adoptive T cell transfer or T cell-activating antibodies anti-OX40/anti-4-1BB, in murine breast cancer models.
[Cell Reports]
Uzhachenko, R. V., Bharti, V., Ouyang, Z., Blevins, A., Mont, S., Saleh, N., Lawrence, H. A., Shen, C., Chen, S.-C., Ayers, G. D., DeNardo, D. G., Arteaga, C., Richmond, A., & Vilgelm, A. E. (2021). Metabolic modulation by CDK4/6 inhibitor promotes chemokine-mediated recruitment of T cells into mammary tumors. Cell Reports, 35(1). https://doi.org/10.1016/j.celrep.2021.108944 Cite
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Platelet Autophagic Machinery Involved in Thrombosis through a Novel Linkage of AMPK-MTOR to Sphingolipid Metabolism

The authors revealed that LC3-II formation and SQSTM1/p62 degradation were noted in H2O2-activated human platelets, which could be blocked by 3-methyladenine and bafilomycin A1, indicating that platelet activation may cause platelet autophagy.
[Autophagy]
Lee, T.-Y., Lu, W.-J., Changou, C. A., Hsiung, Y.-C., Trang, N. T. T., Lee, C.-Y., Chang, T.-H., Jayakumar, T., Hsieh, C.-Y., Yang, C.-H., Chang, C.-C., Chen, R.-J., Sheu, J.-R., & Lin, K.-H. (2021). Platelet autophagic machinery involved in thrombosis through a novel linkage of AMPK-MTOR to sphingolipid metabolism. Autophagy, 0(0), 1–18. https://doi.org/10.1080/15548627.2021.1904495 Cite
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Loss of ARID1A Activates mTOR Signaling and SOX9 in Gastric Adenocarcinoma-Rationale for Targeting ARID1A Deficiency

Genomic alterations in AT-rich interactive domain 1A (ARID1A) were analyzed in gastric adenocarcinoma. Mouse gastric epithelial cells from CK19-Cre-Arid1Afl/fl and wild-type mice were used to determine the activation of oncogenic genes due to loss of Arid1A.
[Gut]
Dong, X., Song, S., Li, Y., Fan, Y., Wang, L., Wang, R., Huo, L., Scott, A., Xu, Y., Pizzi, M. P., Ma, L., Wang, Y., Jin, J., Zhao, W., Yao, X., Johnson, R. L., Wang, L., Wang, Z., Peng, G., & Ajani, J. A. (2021). Loss of ARID1A activates mTOR signaling and SOX9 in gastric adenocarcinoma—rationale for targeting ARID1A deficiency. Gut. https://doi.org/10.1136/gutjnl-2020-322660 Cite
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IL37 Overexpression Inhibits Autophagy and Apoptosis Induced by Hepatic Ischemia Reperfusion Injury via Modulating AMPK/mTOR/ULLK1 Signaling Pathways

Scientists investigated the potential role of IL37 in hepatic ischemia reperfusion injury and its underlying molecular mechanism.
[Life Sciences]
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CD148 Deficiency in Fibroblasts Promotes the Development of Pulmonary Fibrosis

Scientists investigated the role of CD148 in the profibrotic phenotype of fibroblasts in idiopathic pulmonary fibrosis. Conditional CD148 fibroblast-specific knockout mice were generated and exposed to bleomycin, and then assessed for pulmonary fibrosis.
[American Journal of Respiratory and Critical Care Medicine]
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The Oncogene AAMDC Links PI3K-AKT-mTOR Signaling with Metabolic Reprograming in Estrogen Receptor-Positive Breast Cancer

Scientists uncovered that Adipogenesis associated Mth938 domain containing (AAMDC) regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism.
[Nature Communications]
Golden, E., Rashwan, R., Woodward, E. A., Sgro, A., Wang, E., Sorolla, A., Waryah, C., Tie, W. J., Cuyàs, E., Ratajska, M., Kardaś, I., Kozlowski, P., Johnstone, E. K. M., See, H. B., Duffy, C., Parry, J., Lagerborg, K. A., Czapiewski, P., Menendez, J. A., … Blancafort, P. (2021). The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. Nature Communications, 12(1), 1920. https://doi.org/10.1038/s41467-021-22101-7 Cite
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Modulation of the IGF1R-MTOR Pathway Attenuates Motor Neuron Toxicity of Human ALS SOD1G93A Astrocytes

The authors showed elevated activation of the MTOR pathway in human-derived astrocytes harboring mutant SOD1, which resulted in inhibition of macroautophagy/autophagy, increased cell proliferation, and enhanced astrocyte reactivity.
[Autophagy]
Granatiero, V., Sayles, N. M., Savino, A. M., Konrad, C., Kharas, M. G., Kawamata, H., & Manfredi, G. (2021). Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes. Autophagy, 0(0), 1–14. https://doi.org/10.1080/15548627.2021.1899682 Cite
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CASC11 Promotes Aggressiveness of Prostate Cancer Cells through miR-145/IGF1R Axis

The authors explored the potential functions of CASC11 in association with miR-145 and IGF1R during the malignant progression of prostate cancer cells.
[Prostate Cancer and Prostatic Diseases]
Capik, O., Sanli, F., Kurt, A., Ceylan, O., Suer, I., Kaya, M., Ittmann, M., & Karatas, O. F. (2021). CASC11 promotes aggressiveness of prostate cancer cells through miR-145/IGF1R axis. Prostate Cancer and Prostatic Diseases, 1–12. https://doi.org/10.1038/s41391-021-00353-0 Cite
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Role of the mTOR-Autophagy-ER Stress Pathway in High Fructose-Induced Metabolic-Associated Fatty Liver Disease

This review discusses the possible molecular mechanisms of mTOR-autophagy-endoplasmic reticulum (ER) stress in Metabolic-associated fatty liver disease.
[Acta Pharmacologica Sinica]
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Antiviral Drug Screen Identifies DNA-Damage Response Inhibitor as Potent Blocker of SARS-CoV-2 Replication

Scientists developed a medium-throughput drug screening system and identified a small molecule library of 34 of 430 protein kinase inhibitors that were capable of inhibiting SARS-CoV-2 cytopathic effect in human epithelial cells.
[Cell Reports]
Garcia, G., Sharma, A., Ramaiah, A., Sen, C., Purkayastha, A., Kohn, D. B., Parcells, M. S., Beck, S., Kim, H., Bakowski, M. A., Kirkpatrick, M. G., Riva, L., Wolff, K. C., Han, B., Yuen, C., Ulmert, D., Purbey, P. K., Scumpia, P., Beutler, N., … Arumugaswami, V. (2021). Antiviral Drug Screen Identifies DNA-Damage Response Inhibitor as Potent Blocker of SARS-CoV-2 Replication. Cell Reports, 0(0). https://doi.org/10.1016/j.celrep.2021.108940 Cite
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