Tag Archives: MTOR

Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells

Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
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The AKT-Independent MET–V-ATPase–Mtor Axis Suppresses Liver Cancer Vaccination

Scientists investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor (MET, also known as HGFR) on tumor vaccinations for liver cancer in mice.
[Signal Transduction and Targeted Therapy]
Huang, X., Xu, X., Wang, X., Tang, T., Li, E., Zhang, X., Xu, J., Shen, H., Guo, C., Xu, T., Ren, J., Bai, X., & Liang, T. (2020). The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination. Signal Transduction and Targeted Therapy, 5(1), 1–10. https://doi.org/10.1038/s41392-020-0179-x Cite
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ERK/MAPK Signaling Is Essential for Intestinal Development through Wnt Pathway Modulation

Scientists found that deletion of Erk1/2 in intestinal epithelial cells at embryonic stages resulted in an unexpected increase in cell proliferation and migration, expansion of intestinal stem cells and formation of polyp-like structures, leading to postnatal death.
[Development]
ERK/MAPK signaling is essential for intestinal development through Wnt pathway modulation | Development. (n.d.). Retrieved August 7, 2020, from https://dev.biologists.org/content/early/2020/07/30/dev.185678 Cite
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miR-4634 Augments the Anti-Tumor Effects of RAD001 and Associates Well with Clinical Prognosis of Non-Small Cell Lung Cancer

miRNA microarray analysis showed that miR-4634 levels in A549 cells increased significantly after everolimus treatment. Decreased expression of miR-4634 was also found in non-small-cell lung carcinoma cell lines and patients’ tumors by qPCR.
[Scientific Reports]
Liu, S., Zang, H., Zheng, H., Wang, W., Wen, Q., Zhan, Y., Yang, Y., Ning, Y., Wang, H., & Fan, S. (2020). miR-4634 augments the anti-tumor effects of RAD001 and associates well with clinical prognosis of non-small cell lung cancer. Scientific Reports, 10(1), 13079. https://doi.org/10.1038/s41598-020-70157-0 Cite
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Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
Xia, Q., Zhang, H., Zhang, P., Li, Y., Xu, M., Li, X., Li, X., & Dong, L. (2020). Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01400-1 Cite
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Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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A Multimodal Treatment of Carbon Ions Irradiation, miRNA-34 and mTOR Inhibitor Specifically Control High-Grade Chondrosarcoma Cancer Stem Cells

Chondrosarcoma cells were exposed to carbon-ion irradiation, combined with miR-34 mimic and/or rapamycin administration. The effects of treatment on cancer stem cells, stemness-associated phenotype, radioresistance and tumor-initiating properties were evaluated.
[Radiotherapy and Oncology]
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β1 Integrin, ILK and mTOR Regulate Collagen Synthesis in Mechanically Loaded Tendon Cells

Researchers discovered that mechanical stimulation of integrin β1 leads to the phosphorylation of AKT, an event which required the presence of integrin-linked kinase.
[Scientific Reports]
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Discovery of New Fluorescent Thiazole–Pyrazoline Derivatives as Autophagy Inducers by Inhibiting mTOR Activity in A549 Human Lung Cancer Cells

A series of fluorescent thiazole–pyrazoline derivatives was synthesized and their structures were characterized by 1H NMR, 13C NMR, and HRMS. Biological evaluation demonstrated that these compounds could effectively inhibit the growth of human non-small cell lung cancer A549 cells in a dose- and time-dependent manner in vitro and inhibit tumor growth in vivo.
[Cell Death & Disease]
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N-Myristoyltransferase-1 Is Necessary for Lysosomal Degradation and mTORC1 Activation in Cancer Cells

Researchers used genetic and pharmacological inhibition of N-myristoyltransferase-1 (NMT1) to further dissect the role of this enzyme in cancer, and found an unexpected essential role for NMT1 at promoting lysosomal metabolic functions.
[Scientific Reports]
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A Novel 4-Aminoquinazoline Derivative, DHW-208, Suppresses the Growth of Human Breast Cancer Cells by Targeting the PI3K/AKT/mTOR Pathway

Researchers report for the first time that DHW-208 suppressed the growth of human breast cancer cells by inhibiting the PI3K/AKT/mTOR-signaling pathway both in vivo and in vitro.
[Cell Death & Disease]
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Microglia Promote Glioblastoma via mTOR-Mediated Immunosuppression of the Tumor Microenvironment

Investigators showed that glioblastoma (GBM)‐initiating cells induced mTOR signaling in the microglia but not bone marrow‐derived macrophages in both in vitro and in vivo GBM mouse models.
[Embo Journal]
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