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Interferon-A Potentiates Anti-PD-1 Efficacy by Remodeling Glucose Metabolism in the Hepatocellular Carcinoma Microenvironment

[Cancer Discovery] Scientists found that a combination of interferon alpha and anti-PD-1-based immunotherapy resulted in enhanced antitumor activity in unresectable hepatocellular carcinoma patients.

TMPRSS2-ERG Promotes the Initiation of Prostate Cancer by Suppressing Oncogene-Induced Senescence

[Cancer Gene Therapy] In primary prostate luminal epithelial cells, following inducible oncogenic Kras expression or Pten depletion, TMPRSS2-ERG suppressed oncogene-induced senescence, independent of TP53 induction and RB1 inhibition.

Application of a Fluorescent H2S Probe Based on Excited-State Intramolecular Proton Transfer for Detecting Latent Mechanism of H2S-Induced MCF-7 Apoptosis

[Future Medicinal Chemistry] FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect H2S in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis.

Protrudin Regulates FAK Activation, Endothelial Cell Migration and Angiogenesis

[Cellular and Molecular Life Sciences] Researchers investigated the role of the endoplasmic reticulum-anchored protein, Protrudin, in endothelial cell protrusion, migration and angiogenesis.

IL-1β-Activated mTORC2 Promotes Accumulation of IFN-γ+ γδ T Cells by Upregulating CXCR3 to Restrict Hepatic Fibrosis

[Cell Death & Disease] Researchers investigated the functional subsets of γδ T cells in hepatic fibrosis and to further explore the underlying causes and drivers of migration.

mTOR Inhibition and Trastuzumab-Emtansine (T-DM1) in HER2-Positive Breast Cancer

[Molecular Cancer Research] Everolimus in combination with T-DM1 showed strong antitumor effects in HER2-positive breast cancer, both in vitro and in vivo.