Tag Archives: MTOR

Fasting Improves Therapeutic Response in Hepatocellular Carcinoma through p53-Dependent Metabolic Synergism

Scientists showed in hepatocellular carcinoma (HCC) cells, xenografts, and patient-derived organoids that fasting improved sorafenib efficacy and acted synergistically to sensitize sorafenib-resistant HCC.
[Science Advances]
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Inhibition of MCL1 Induces Apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma

To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.
[Scientific Reports]
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SLAMF3 and SLAMF4 Are Immune Checkpoints That Constrain Macrophage Phagocytosis of Hematopoietic Tumors

Investigators reported a critical role of SLAM family receptors, ubiquitously expressed on hematopoietic cells and forming homotypic interactions, in constraining macrophage phagocytosis.
[Science Immunology]
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Caffeic Acid Phenethyl Ester Induces Radiosensitization via Inhibition of DNA Damage Repair in Androgen-Independent Prostate Cancer Cells

Investigators studied the effect of co-treatment of caffeic acid phenethyl ester (CAPE) and gamma radiation on androgen-independent DU145 and PC3 cells. The combination treatment sensitized prostate cancer cells to radiation in a dose-dependent manner. The radiosensitizing effect of CAPE was observed in both cell lines.
[Environmental Toxicology]
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Prostate Cancer Cell Proliferation Is Influenced by LDL-Cholesterol Availability and Cholesteryl Ester Turnover

As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, researchers hypothesized that castrate-resistant/advanced prostate cancer cell growth was influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholesterol, which was coupled to intracellular cholesteryl ester homeostasis.
[Cancer & Metabolism]
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CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma

Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two hepatocellular carcinoma (HCC) cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.
[Cancer Research]
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Androgens Increase Excitatory Neurogenic Potential in Human Brain Organoids

Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.
[Nature]
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IFN-γ Affects Pancreatic Cancer Properties by MACC1-AS1/MACC1 Axis via AKT/mTOR Signaling Pathway

Rescue assays of cells overexpressing Metastasis-related in colon cancer 1 (MACC1)-AS1 and of cells silencing MACC1 were performed and cellular properties and proteins were assessed by the above-mentioned assays as well.
[Clinical and Translational Medicine]
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Subcutaneous Nanotherapy Repurposes the Immunosuppressive Mechanism of Rapamycin to Enhance Allogeneic Islet Graft Viability

Researchers demonstrated that subcutaneous delivery via poly(ethylene glycol)-b-poly(propylene sulfide) polymersome nanocarriers significantly altered rapamycin’s cellular biodistribution to repurpose its mechanism of action for tolerance, instead of immunosuppression, and minimize side effects.
[Nature Nanotechnology]
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CDC42 Controlled Apical-Basal Polarity Regulates Intestinal Stem Cell to Transit Amplifying Cell Fate Transition via YAP-EGF-mTOR Signaling

The authors found that CDC42 loss initiated in the intestinal stem cell caused a drastic hyperproliferation of transit amplifying cells and disrupted epithelial polarity.
[Cell Reports]
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Bone Mesenchymal Stem Cell-Derived Exosomal microRNA-7-5p Inhibits Progression of Acute Myeloid Leukemia by Targeting OSBPL11

Researchers investigated the effects of exosomes derived from bone marrow mesenchymal stem cells on the regulation of acute myeloid leukemia and the underlying mechanisms mediated by microRNA.
[Journal of Nanobiotechnology]
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