Dual Akt and Bcl-2 Inhibition Induces Cell-Type Specific Modulation of Apoptotic and Autophagic Signaling in Castration Resistant Prostate Cancer Cell Lines

The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).
[Molecular Biology Reports]
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A Novel and Highly Effective Mitochondrial Uncoupling Drug in T-Cell Leukemia

MB1-47 treatment in T-cell acute lymphoblastic leukemia cells robustly inhibited cell proliferation via both cytostatic and cytotoxic effects as a result of compromised mitochondrial energy and metabolite depletion, which severely impaired nucleotide biosynthesis.
[Blood]
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MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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Biomaterial-Enabled Induction of Pancreatic-Specific Regulatory T Cells through Distinct Signal Transduction Pathways

Scientists used poly (lactic-co-glycolide) to co-encapsulate type 1 diabetes-relevant antigen and 3 distinct TREG-inducing molecules – rapamycin, all-trans retinoic acid, and butyrate – that targeted the mechanistic target of Rapa, the retinoid pathway, and histone deacetylase inhibition, respectively.
[Drug Delivery and Translational Research]
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ECHS1, an Interacting Protein of LASP1, Induces Sphingolipid-Metabolism Imbalance to Promote Colorectal Cancer Progression by Regulating Ceramide Glycosylation

Through an LC–MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer.
[Cell Death & Disease]
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γδ T Cells Support Antigen-Specific αβ T Cell-Mediated Antitumor Responses during BCG Treatment for Bladder Cancer

Scientists showed that Bacillus Calmette-Guérin (BCG) increased the number of tumor antigen-specific αβ T cells in patients with bladder cancer.
[Cancer Immunology Research]
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Involvement of Multiple Scavenger Receptors in Advanced Glycation End Product-Induced Vessel Tube Formation in Endothelial Cells

Researchers examined the involvement of advanced glycation end (AGE)-related receptors on AGE-induced angiogenesis in endothelial cells.
[Experimental Cell Research]
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Human Cardiac Stem Cells Rejuvenated by Modulating Autophagy with MHY-1685 Enhance the Therapeutic Potential for Cardiac Repair

Scientists employed MHY-1685, a novel mammalian target of rapamycin inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation.
[Experimental and Molecular Medicine]
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Curcumol Inhibits the Malignant Progression of Prostate Cancer and Regulates the PDK1/AKT/mTOR Pathway by Targeting miR-9

Researchers analyzed the effect of curcumol on prostate cancer and identify its possible internal regulatory pathway using in vitro cell culture and in vivo tumor model experiments.
[Oncology Reports]
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Tanshinone IIA Affects the Malignant Growth of Cholangiocarcinoma Cells by Inhibiting the PI3K-Akt-mTOR Pathway

The anti-cancer effects of Tanshinone IIA (Tan-IIA) were investigated by using subcutaneous tumorigenic model in nude mice and in the human cholangiocarcinoma cell lines in vitro. Tan-IIA treatment considerably suppressed the proliferation and migration of Cholangiocarcinoma cells while inducing apoptosis of Cholangiocarcinoma cells.
[Scientific Reports]
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Predictive Biomarkers for Systemic Therapy of Hepatocellular Carcinoma

Scientists cover the recent advancements in the identification of proteomic/genomic/epigenomic/transcriptomic biomarkers for predicting hepatocellular carcinoma treatment efficacy with the use of multi-kinase inhibitors, CDK4/6 inhibitors, and immune checkpoint inhibitors.
[Expert Review of Molecular Diagnostics]
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