Oestrogen Deprivation Induces Chemokine Production and Immune Cell Recruitment in In Vitro and In Vivo Models of Oestrogen Receptor-Positive Breast Cancer

Scientists investigated the effect of oestrogen deprivation on the expression of chemokines and immune infiltration in vitro and in an ER+ immunocompetent mouse model.
[Breast Cancer Research]
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Fluid Flow Exposure Promotes Epithelial-to-Mesenchymal Transition and Adhesion of Breast Cancer Cells to Endothelial Cells

Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.
[Breast Cancer Research]
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Loss of TRIM31 Promotes Breast Cancer Progression through Regulating K48- and K63-Linked Ubiquitination of p53

The authors showed that TRIM31 was downregulated in breast cancer tissues and negatively correlated with breast cancer progression. Both gain- and loss-of-function assays indicated that TRIM31 inhibited the proliferation, colony formation, migration, and invasion of breast cancer cells.
[Cell Death & Disease]
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The Long Non-Coding RNA ET-20 Mediates EMT by Impairing Desmosomes in Breast Cancer Cells

Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.
[Journal of Cell Science]
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MINDY1 Promotes Breast Cancer Cell Proliferation by Stabilizing Estrogen Receptor α

The authors identified MINDY1, a member belongs to the motif interacting with Ubcontaining novel DUB family (MINDY), as a potential deubiquitylase of estrogen receptor α in breast cancer.
[Cell Death & Disease]
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Sauchinone Inhibits the Proliferation, Migration and Invasion of Breast Cancer Cells by Suppressing Akt-CREB-MMP13 Signaling Pathway

Scientists investigated the effects of sauchinone on the growth of breast cancer cells along with the underlying molecular mechanisms. Their results showed that sauchinone treatment markedly inhibited the proliferation, migration, and invasion of breast cancer cells.
[Bioscience Reports]
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RNA Binding Protein RBMS3 Is a Common EMT Effector That Modulates Triple-Negative Breast Cancer Progression via Stabilizing PRRX1 mRNA

Scientists identified RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) as a novel and common effector of epithelial-to-mesenchymal transition (EMT), which could be a promising therapeutic target for triple-negative breast cancer treatment.
[Oncogene]
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Transmembrane Protein 97 Exhibits Oncogenic Properties via Enhancing LRP6-Mediated Wnt Signaling in Breast Cancer

Researchers revealed that transmembrane protein 97 was a positive modulator of canonical Wnt signaling which was implicated in the tumorigenesis of breast cancer.
[Cell Death & Disease]
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PEAK1 Promotes Invasion and Metastasis and Confers Drug Resistance in Breast Cancer

The authors investigated pseudopodium-enriched atypical kinase 1 (PEAK1) expression in breast cancer and its role in breast cancer cells in vitro and in vivo and analyzed the relationship with clinicopathological status and chemotherapy resistance.
[Clinical and Experimental Medicine]
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Emerging Role of Ferroptosis in Breast Cancer: New Dawn for Overcoming Tumor Progression

Investigators discuss the roles of ferroptosis-associated modulators glutathione, glutathione peroxidase 4, iron, nuclear factor erythroid-2 related factor-2, superoxide dismutases, lipoxygenase and coenzyme Q in breast cancer and provide evidence that ferroptosis inducers eliminate breast cancer cells.
[Pharmacology & Therapeutics]
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Targeting Neurons in the Tumor Microenvironment with Bupivacaine Nanoparticles Reduces Breast Cancer Progression and Metastases

The authors designed PEGylated lipid nanoparticles loaded with a non-opioid analgesic, bupivacaine, to target neurons within breast cancer tumors and suppress nerve-to-cancer cross-talk.
[Science Advances]
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