SELENOF Is a New Tumor Suppressor in Breast Cancer

Restoring SELENOF could attenuate a number of aggressive cancer phenotypes in breast cancer cells, including clonogenic survival, and enhance the response to drugs or radiation used in breast cancer therapy.
[Oncogene]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Targeted Nanoparticle for Co-Delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis

A single therapeutic was developed based on trastuzumab-conjugated nanoparticles for co-delivering docetaxel and siRNA against HER2.
[Small]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Effects of Matcha Tea Extract on Cell Viability and Peroxisome Proliferator-Activated Receptor γ Expression on T47D Breast Cancer Cells

Researchers investigated the nuclear peroxisome proliferator-activated receptor gamma-dependent proliferation behavior of breast cancer cells after stimulation with matcha green tea extract.
[Archives of Gynecology and Obstetrics]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Tanshinone IIA Attenuates the Stemness of Breast Cancer Cells via Targeting the miR-125b/STARD13 Axis

In vitro mammary spheroid formation, flow cytometry assay on CD24−/CD44+ sub-population, ALDH activity detection, cell viability assay and western blot analysis, and in vivo tumor-initiating analysis were performed to examine the effects of Tanshinone IIA on the stemness of breast cancer cells.
[Experimental Hematology & Oncology]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

RICH1 Inhibits Breast Cancer Stem Cell Traits through Activating Kinases Cascade of Hippo Signaling by Competing with Merlin for Binding to Amot-p80

Scientists found that the low expression of RICH1 in breast cancer was associated with poor prognosis. Depletion of RICH1 promoted the stemness and disrupted the normal epithelial architecture of MCF10A cells.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Herceptin-Conjugated Magnetic Polystyrene-Agsbox Nanoparticles as a Theranostic Agent for Breast Cancer

Researchers demonstrated selective binding, effective uptake of herceptin (HER)-conjugated magnetic polystyrene-Agsbox nanoparticles into MDA-MB-231and SKBR-3 cell lines with no effect against L929.
[Journal of Biomaterials Applications]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

C/EBPβ Isoform-Specific Regulation of Migration and Invasion in Triple-Negative Breast Cancer Cells

Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.
[npj Breast Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Lineage-Specific Silencing of PSAT1 Induces Serine Auxotrophy and Sensitivity to Dietary Serine Starvation in Luminal Breast Tumors

Investigators analyzed lineage-dependent gene expression in human breast tumors to identify differences in metabolic gene expression that may limit pathway redundancy and create therapeutic vulnerabilities.
[Cell Reports]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticleGraphical Abstract
Bookmark

No account yet? Register

Share

C/EBPB-Dependent Adaptation to Palmitic Acid Promotes Tumor Formation in Hormone Receptor Negative Breast Cancer

Scientists demonstrated that obesity-associated tumor formation was driven by cellular adaptation rather than expansion of pre-existing clones within the cancer cell population.
[Nature Communications]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full ArticlePress Release
Bookmark

No account yet? Register

Share

Stem-Like Breast Cancer Cells in the Activated State Resist Genetic Stress via TGFBI-ZEB1

The authors characterized a population of stem-like breast cancer cells expressing the integrin αvβ3 as transcriptionally related to activated stem/basal cells in the normal human mammary gland.
[npj Breast Cancer]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Exosomal circCARM1 from Spheroids Reprograms Cell Metabolism by Regulating PFKFB2 in Breast Cancer

The authors investigated breast cancer cell metabolism reprogramming by circular RNAs (circRNAs) from breast cancer stem cell (BCSC) exosomes and found that BCSC exosome-derived circCARM1 played an important role in breast cancer cell glycolysis by sponging miR-1252-5p which regulated PFKFB2 expression.
[Oncogene]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share