The authors summarize the latest advances regarding the particular involvement of point mutations of estrogen receptor alpha (ERα) in endocrine resistance. They also discuss the involvement of synonymous ERα mutations with respect to co-translational folding of the receptor and ribosome biogenesis in breast carcinogenesis.
[International Journal of Molecular Sciences]
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Autophagosome formation and autophagic flux were assessed by evaluating endogenous LC3-II levels and ectopic expression of EGFP-LC3 and mRFP-EGFP-LC3 in breast cancer cells.
[British Journal of Cancer]
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Scientists report that genetic SIRT5 disruption in breast cancer cell lines and mouse models caused increased succinylation of IDH2 and other metabolic enzymes, increased oxidative stress, and impaired transformation and tumorigenesis.
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Abril, Y. L. N., Fernandez, I. R., Hong, J. Y., Chiang, Y.-L., Kutateladze, D. A., Zhao, Q., Yang, M., Hu, J., Sadhukhan, S., Li, B., He, B., Remick, B., Bai, J. J., Mullmann, J., Wang, F., Maymi, V., Dhawan, R., Auwerx, J., Southard, T., … Weiss, R. S. (2021). Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01637-w Cite
The authors report an important role for BRCA1P1, the pseudogene of the BRCA1 tumor suppressor gene, in regulating innate immune defense mechanisms in breast cancer cells.
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Han, Y. J., Zhang, J., Lee, J.-H., Mason, J. M., Karginova, O., Yoshimatsu, T. F., Hao, Q., Hurley, I., Brunet, L. P., Prat, A., Prasanth, K. V., Gack, M. U., & Olopade, O. I. (2021). The BRCA1 Pseudogene Negatively Regulates Anti-Tumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1959 Cite
Researchers subjected low-glycolytic breast cancer cells to different microenvironmental selection pressures using combinations of hypoxia, acidosis, low glucose, and starvation for many months and isolated single clones for metabolic and transcriptomic profiling.
[Proceedings of the National Academy of Sciences of the United States of America]
Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Investigators examined the direct influence of β-arrestins on cellular function and gene expression profiles by changing their expression levels in breast cancer cells, MDA-MB-231 and MDA-MB-468.
The authors found that interfering with expression of the receptor for the lactogenic hormone prolactin in breast cancer cells representative of the luminal and epithelial breast cancer subtypes resulted in loss of their differentiation state, enriched for stem-like cell subpopulations, and increased their tumorigenic capacity in a subtype-specific manner.
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Shams, A., Binothman, N., Boudreault, J., Wang, N., Shams, F., Hamam, D., Tian, J., Moamer, A., Dai, M., Lebrun, J.-J., & Ali, S. (2021). Prolactin receptor-driven combined luminal and epithelial differentiation in breast cancer restricts plasticity, stemness, tumorigenesis and metastasis. Oncogenesis, 10(1), 1–16. https://doi.org/10.1038/s41389-020-00297-5 Cite
To understand the potential effects of cancer cells on surrounding normal mammary epithelial cells, researchers performed direct co-culture of non-tumorigenic mammary epithelial MCF10A cells and various breast cancer cells.
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Jo, S. H., Heo, W. H., Son, H.-Y., Quan, M., Hong, B. S., Kim, J. H., Lee, H.-B., Han, W., Park, Y., Lee, D.-S., Kwon, N. H., Park, M. C., Chae, J., Kim, J.-I., Noh, D.-Y., & Moon, H.-G. (2021). S100A8/A9 mediate the reprograming of normal mammary epithelial cells induced by dynamic cell–cell interactions with adjacent breast cancer cells. Scientific Reports, 11(1), 1337. https://doi.org/10.1038/s41598-020-80625-2 Cite
Researchers investigated the therapeutic efficacy of cyanobacteria derived monogalactosyldiacylglycerol to inhibit breast cancer cell growth.
The authors examined whether three commonly prescribed selective serotonin reuptake inhibitors (SSRIs), fluoxetine, sertraline and citalopram, affected proliferation or glucose uptake of human breast and ovarian cancer cell lines characterized by different malignancies and metastatic potential.
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