Scientists investigated whether Newcastle disease virus (NDV)‐D90, a novel strain isolated from natural sources in China, promoted apoptosis by modulating the expression of ERα or the GPER in breast cancer cells exposed to 17β‐estradiol.
[Journal of Cellular Biochemistry]
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NDV‐D90 inhibits 17β‐estradiol‐mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells - Shan - - Journal of Cellular Biochemistry - Wiley Online Library. (n.d.). Retrieved September 29, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/jcb.28118 Cite
Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
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Knockdown of S100A10 in breast cancer cells suppressed and overexpression of S100A10 in breast cancer patient‐derived tumor xenograft cells enhanced their invasion abilities and 3D organoid formation capacities in vitro.
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Yanagi, H., Watanabe, T., Nishimura, T., Hayashi, T., Kono, S., Tsuchida, H., Hirata, M., Kijima, Y., Takao, S., Okada, S., Suzuki, M., Imaizumi, K., Kawada, K., Minami, H., Gotoh, N., & Shimono, Y. (n.d.). Upregulation of S100A10 in metastasized breast cancer stem cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14659 Cite
Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
By qualitatively and quantitatively monitoring the real-time movements of live cells researchers provided the first evidence that pple polyphenol extract inhibited the migration of MDA-MB-231 and MDA-MB-468 TNBC cells and downregulated metalloproteinase-2 and metalloproteinase-9.
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Vuoso, D. C., D’Angelo, S., Ferraro, R., Caserta, S., Guido, S., Cammarota, M., Porcelli, M., & Cacciapuoti, G. (2020). Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling. Scientific Reports, 10(1), 15921. https://doi.org/10.1038/s41598-020-73092-2 Cite
In vitro, Ambrisentan inhibited both spontaneous and induced migration/invasion capacity of different tumor cells. Whole transcriptome analysis using RNAseq indicated Ambrisentan’s inhibitory effects on the whole transcriptome of resting and PAR2-activated COLO-357 cells, which tended to normalize to an unstimulated profile.
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Kappes, L., Amer, R. L., Sommerlatte, S., Bashir, G., Plattfaut, C., Gieseler, F., Gemoll, T., Busch, H., Altahrawi, A., Al-Sbiei, A., Haneefa, S. M., Arafat, K., Schimke, L. F., Khawanky, N. E., Schulze-Forster, K., Heidecke, H., Kerstein-Staehle, A., Marschner, G., Pitann, S., … Cabral-Marques, O. (2020). Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis. Scientific Reports, 10(1), 15931. https://doi.org/10.1038/s41598-020-72960-1 Cite
As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling.
[npj Breast Cancer]
HSD17B4 was highly expressed in the vast majority of human cancers, and its methylation was present only in breast cancers and one lymphoblastic leukemia cell line.
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Yamashita, S., Hattori, N., Fujii, S., Yamaguchi, T., Takahashi, M., Hozumi, Y., Kogawa, T., El-Omar, O., Liu, Y.-Y., Arai, N., Mori, A., Higashimoto, H., Ushijima, T., & Mukai, H. (2020). Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy. Scientific Reports, 10(1), 15530. https://doi.org/10.1038/s41598-020-72661-9 Cite
Investigators report that Furin was frequently overexpressed in TNBC tumors and this correlated with poor prognosis in patients with TNBC tumors.
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Scientists tested the effectiveness of a novel class of 1,1-diarylethylene FOXM1 inhibitory compounds in suppressing TNBC cell migration, invasion, and metastasis using in vitro cell culture and in vivo tumor models.
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Dey, P., Wang, A., Ziegler, Y., Kim, S. H., El-Ashry, D., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2020). Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer. Cancers, 12(9), 2677. https://doi.org/10.3390/cancers12092677 Cite
Researchers sought to understand the effects of CDK4/6 inhibition and radiation in multiple preclinical breast cancer models.
[Clinical Cancer Research]
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Pesch, A. M., Hirsh, N., Chandler, B. C., Michmerhuizen, A. R., Ritter, C. L., Androsiglio, M., Wilder-Romans, K., Liu, M., Gersch, C., Larios, J. M., Pierce, L. J., Rae, J. M., & Speers, C. (2020). Short Term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor Positive Breast Cancers. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-2269 Cite