Flow cytometric analyses indicated that induction of epithelial-mesenchymal transition decreased trastuzumab binding, prior to overt loss of HER2 expression in trastuzumab-emtansine-resistant (TDM1R) cells. Kinome analyses of TDM1R cells indicated increased phosphorylation of ErbB1, ErbB4, and FGFR1.
[npj Breast Cancer]
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Akhand, S. S., Chen, H., Purdy, S. C., Liu, Z., Anderson, J. C., Willey, C. D., & Wendt, M. K. (2021). Fibroblast growth factor receptor facilitates recurrence of minimal residual disease following trastuzumab emtansine therapy. Npj Breast Cancer, 7(1), 1–11. https://doi.org/10.1038/s41523-020-00213-5 Cite
The authors summarize the latest advances regarding the particular involvement of point mutations of estrogen receptor alpha (ERα) in endocrine resistance. They also discuss the involvement of synonymous ERα mutations with respect to co-translational folding of the receptor and ribosome biogenesis in breast carcinogenesis.
[International Journal of Molecular Sciences]
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Investigators discuss the cellular phenotypes and spatial patterns of the lymphoid-, myeloid-, and stromal cells in the TNBC microenvironment and the potential value of mapping these features onto tumor cell genotypes.
Autophagosome formation and autophagic flux were assessed by evaluating endogenous LC3-II levels and ectopic expression of EGFP-LC3 and mRFP-EGFP-LC3 in breast cancer cells.
[British Journal of Cancer]
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Scientists report that genetic SIRT5 disruption in breast cancer cell lines and mouse models caused increased succinylation of IDH2 and other metabolic enzymes, increased oxidative stress, and impaired transformation and tumorigenesis.
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Abril, Y. L. N., Fernandez, I. R., Hong, J. Y., Chiang, Y.-L., Kutateladze, D. A., Zhao, Q., Yang, M., Hu, J., Sadhukhan, S., Li, B., He, B., Remick, B., Bai, J. J., Mullmann, J., Wang, F., Maymi, V., Dhawan, R., Auwerx, J., Southard, T., … Weiss, R. S. (2021). Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer. Oncogene, 1–15. https://doi.org/10.1038/s41388-020-01637-w Cite
The authors report an important role for BRCA1P1, the pseudogene of the BRCA1 tumor suppressor gene, in regulating innate immune defense mechanisms in breast cancer cells.
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Han, Y. J., Zhang, J., Lee, J.-H., Mason, J. M., Karginova, O., Yoshimatsu, T. F., Hao, Q., Hurley, I., Brunet, L. P., Prat, A., Prasanth, K. V., Gack, M. U., & Olopade, O. I. (2021). The BRCA1 Pseudogene Negatively Regulates Anti-Tumor Responses through Inhibition of Innate Immune Defense Mechanisms. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1959 Cite
Cairnsurgical, Inc. announced that the first patient has been treated in its US pivotal trial of the Breast Cancer Locator System at Massachusetts General Hospital.
[Cairnsurgical, Inc. (Business Wire, Inc.)]
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Researchers subjected low-glycolytic breast cancer cells to different microenvironmental selection pressures using combinations of hypoxia, acidosis, low glucose, and starvation for many months and isolated single clones for metabolic and transcriptomic profiling.
[Proceedings of the National Academy of Sciences of the United States of America]
Daiichi Sankyo Company, Ltd. and AstraZeneca’s ENHERTU® has been granted conditional approval in the European Union (EU) as a monotherapy for the treatment of adult patients with unresectable or metastatic HER2 positive breast cancer who have received two or more prior anti-HER2 based regimens.
[Daiichi Sankyo Company, Ltd.]
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Investigators summarize the critical roles of miRNAs in regulating multiple signaling pathways such as Wnt/β-catenin, Notch, PI3K/AKT/mTOR, BMI-1 and STAT3 that are important for the breast cancer stem cell maintenance.
[Cancer Cell International]
Using conditional knockout and reporter mouse models, the authors demonstrated that tumor cells expressing the Notch ligand Dll1 was important for tumor growth and metastasis and bear similarities to tumor-initiating cancer cells in breast cancer.
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Kumar, S., Nandi, A., Singh, S., Regulapati, R., Li, N., Tobias, J. W., Siebel, C. W., Blanco, M. A., Klein-Szanto, A. J., Lengner, C., Welm, A. L., Kang, Y., & Chakrabarti, R. (2021). Dll1 + quiescent tumor stem cells drive chemoresistance in breast cancer through NF-κB survival pathway. Nature Communications, 12(1), 432. https://doi.org/10.1038/s41467-020-20664-5 Cite