Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells

Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
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Myeloid-Derived Suppressor Cell Depletion Therapy Targets IL-17A-Expressing Mammary Carcinomas

Investigators report here that IL-17A mRNA and protein were detectable in some human triple-negative breast cancer cell lines and further upregulated by IL-23 and LPS stimulation.
[Scientific Reports]
Dawod, B., Liu, J., Gebremeskel, S., Yan, C., Sappong, A., Johnston, B., Hoskin, D. W., Marshall, J. S., & Wang, J. (2020). Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas. Scientific Reports, 10(1), 13343. https://doi.org/10.1038/s41598-020-70231-7 Cite
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EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma

Scientists report that Eph receptor A5 (EPHA5) mutations were associated with increased tumor mutation burden, neoantigen load, levels of immune-related gene expression signatures, and enhanced tumor-infiltrating lymphocytes in lung adenocarcinoma.
[Cancer Gene Therapy]
Huang, W., Lin, A., Luo, P., Liu, Y., Xu, W., Zhu, W., Wei, T., Lyu, Q., Guo, L., & Zhang, J. (2020). EPHA5 mutation predicts the durable clinical benefit of immune checkpoint inhibitors in patients with lung adenocarcinoma. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-020-0207-6 Cite
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AUF1 Promotes Stemness in Human Mammary Epithelial Cells through Stabilization of the EMT Transcription Factors TWIST1 and SNAIL1

Scientists showed that AU-rich element RNA-binding protein 1 was an important inducer of the epithelial-to-mesenchymal transition process through stabilization of SNAIL1 and TWIST1 and the consequent promotion of breast cancer stem cells.
[Oncogenesis]
AUF1 promotes stemness in human mammary epithelial cells through stabilization of the EMT transcription factors TWIST1 and SNAIL1 | Oncogenesis. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41389-020-00255-1 Cite
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

Researchers summarized recent literature regarding molecules and pathways and reviewed the effects of cancer stem cells biology during the formation of brain metastasis in TNBC.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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Natural Polysaccharide Derived Carbon Dot Based In Situ Facile Green Synthesis of Silver Nanoparticles: Synergistic Effect on Breast Cancer

Carbon dot showed selective cytotoxicity against MCF7 breast cancer cells with the IC50 of 10 μg/ml while carbon dot based silver nanoparticles demonstrated synergistic effect on cytotoxicity.
[International Journal of Biological Macromolecules]
Ghosal, K., Ghosh, S., Ghosh, D., & Sarkar, K. (2020). Natural polysaccharide derived carbon dot based in situ facile green synthesis of silver nanoparticles: Synergistic effect on breast cancer. International Journal of Biological Macromolecules. https://doi.org/10.1016/j.ijbiomac.2020.07.315 Cite
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Rosmarinic Acid-Induced Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

Researchers evaluated the effects and mechanisms of rosmarinic acid (RA) in two racially different TNBC cell lines. Results obtained showed that RA significantly caused cytotoxic and antiproliferative effects in both cell lines in a dose- and time-dependent manner. RA induced cell cycle arrest-related apoptosis and altered the expression of many apoptosis-involved genes differently.
[European Journal of Pharmacology]
Messeha, S. S., Zarmouh, N. O., Asiri, A., & Soliman, K. F. A. (2020). Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology, 173419. https://doi.org/10.1016/j.ejphar.2020.173419 Cite
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Distinct Phenotypes of Cancer Cells on Tissue Matrix Gel

Scientists investigated mammary epithelial cell phenotypes and metabolic profiles on animal breast extracellular matrix-derived tissue matrix gel, Col I, and Matrigel. Atomic force microscopy, fluorescence microscopy, acini formation assay, differentiation experiments, spatial migration/invasion assays, proliferation assay, and nuclear magnetic resonance spectroscopy were used to examine biological phenotypes and metabolic changes.
[Breast Cancer Research]
Distinct phenotypes of cancer cells on tissue matrix gel | Breast Cancer Research | Full Text. (n.d.). Retrieved August 6, 2020, from https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-020-01321-7 Cite
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PRMT1-Dependent Methylation of BRCA1 Contributes to the Epigenetic Defense of Breast Cancer Cells against Ionizing Radiation

Investigators found that by activating PRMT1, irradiation triggered a BRCA1-dependent program that resulted in efficient DNA repair and inhibition of apoptosis. Depletion of PRMT1 in irradiated cells resulted in a switch of BRCA1 functions from repair and survival in the nucleus to activation of cell death signals in the cytoplasm.
[Scientific Reports]
PRMT1-dependent methylation of BRCA1 contributes to the epigenetic defense of breast cancer cells against ionizing radiation | Scientific Reports. (n.d.). Retrieved August 6, 2020, from https://www.nature.com/articles/s41598-020-70289-3 Cite
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Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells

The nanocomplexes formed by metallodendrimers and different siRNA were examined for their zeta potential and size, and by transmission electron microscopy, fluorescence polarisation, circular dichroism, and electrophoresis. The internalisation of dendriplexes was estimated by flow cytometry and confocal microscopy in a human breast cancer cell line, following the ability of these metallodendrimers to deliver the siRNA into the cell. In vitro cell viability experiments have indicated effective interactions between Cu (II) dendrimers and pro-apoptotic siRNAs: Mcl-1 and Bcl-2 in breast cancer cells.
[Pharmaceutics]
Sanz del Olmo, N., Holota, M., Michlewska, S., Gómez, R., Ortega, P., Ionov, M., de la Mata, F. J., & Bryszewska, M. (2020). Copper (II) Metallodendrimers Combined with Pro-Apoptotic siRNAs as a Promising Strategy Against Breast Cancer Cells. Pharmaceutics, 12(8), 727. https://doi.org/10.3390/pharmaceutics12080727 Cite
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Daiichi Sankyo and AstraZeneca Enter New Global Development and Commercialization Collaboration for Daiichi Sankyo’s ADC DS-1062

Daiichi Sankyo Company, Limited announced that it has entered into a global development and commercialization agreement with AstraZeneca for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate, currently in Phase I clinical development for non-small cell lung cancer and TNBC.
[Daiichi Sankyo Ltd.]
Press Release

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Merck Announces Two US Regulatory Milestones for KEYTRUDA® (pembrolizumab) in Triple-Negative Breast Cancer (TNBC)

Merck announced that the FDA has accepted two new supplemental Biologics License Applications for KEYTRUDA, Merck’s anti-PD-1 therapy.
[Merck]
Press Release

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