Tag Archives: breast cancer

Identification of Shared Tumor Epitopes from Endogenous Retroviruses Inducing High-Avidity Cytotoxic T Cells for Cancer Immunotherapy

Six candidates among the most commonly shared HLA-A2 epitopes with evidence of translation were selected for immunological evaluation. In vitro priming assays confirmed the immunogenicity of these epitopes, which induced high-avidity CD8+ T cell clones.
[Science Advances]
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Mapping Molecular Subtype Specific Alterations in Breast Cancer Brain Metastases Identifies Clinically Relevant Vulnerabilities

The authors comprehensively dissected genomic, transcriptomic and clinical data in patient-matched longitudinal tumor samples, and unraveled distinct transcriptional programs enriched in brain metastasis.
[Nature Communications]
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IKBKE Phosphorylates and Stabilizes Snail to Promote Breast Cancer Invasion and Metastasis

Researchers revealed a novel oncogenic function of IKBKE in promoting breast cancer metastasis by governing Snail abundance, and highlighted the potential of targeting IKBKE for metastatic breast cancer therapies.
[Cell Death & Differentiation]
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Flexible Etherified and Esterified Triphenylethylene Derivatives and Their Evaluation on ER Positive and Triple Negative Breast Cancer Cell Lines

Tamoxifen (TAM) is a selective estrogen receptor modulator with potential clinical benefits for all stages of breast cancer. Investigators reported novel TAM analogues that could avoid metabolism via CYP2D6.
[Chemmedchem]
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Prognostic Implications of N6-Methyladenosine RNA Regulators in Breast Cancer

Investigators used a series of bioinformatics methods and experiments to conduct exploratory research on the possible role of m6A regulators in breast cancer (BC) and revealed that YTHDF1 could serve as a new molecular marker for BC immunotherapy.
[Scientific Reports]
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SELENOF Is a New Tumor Suppressor in Breast Cancer

Restoring SELENOF could attenuate a number of aggressive cancer phenotypes in breast cancer cells, including clonogenic survival, and enhance the response to drugs or radiation used in breast cancer therapy.
[Oncogene]
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Tumor ENPP1(CD203a)/Haptoglobin Axis Exploits Myeloid-Derived Suppressor Cells to Promote Post-Radiotherapy Local Recurrence in Breast Cancer

Researchers unveiled the ectonucleotide pyrophosphatase /phosphodiesterase 1 (ENPP1)/HP axis as an unanticipated mechanism exploited by tumor cells linking inflammation to immune remodeling favoring local relapse.
[Cancer Discovery]
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Targeted Nanoparticle for Co-Delivery of HER2 siRNA and a Taxane to Mirror the Standard Treatment of HER2+ Breast Cancer: Efficacy in Breast Tumor and Brain Metastasis

A single therapeutic was developed based on trastuzumab-conjugated nanoparticles for co-delivering docetaxel and siRNA against HER2.
[Small]
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Effects of Matcha Tea Extract on Cell Viability and Peroxisome Proliferator-Activated Receptor γ Expression on T47D Breast Cancer Cells

Researchers investigated the nuclear peroxisome proliferator-activated receptor gamma-dependent proliferation behavior of breast cancer cells after stimulation with matcha green tea extract.
[Archives of Gynecology and Obstetrics]
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Role of Nischarin in the Pathology of Diseases: A Special Emphasis on Breast Cancer

The authors report the prognostic value, clinical relevance, and biological significance of the Nischarin gene in breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas datasets.
[Oncogene]
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Targeting HER2+ Breast Cancer Brain Metastases: A Review of Brain-Directed HER2-Directed Therapies

HER2-targeted therapies, including antibody-drug conjugates, have presented new therapeutic options for this patient population; however, additional data for both small-molecule inhibitors and antibody-drug conjugates with respect to patients with central nervous system metastases is needed. Scientists specifically review the data for the management of HER2+ parenchymal brain metastases.
[CNS Drugs]
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