NDV-D90 Inhibits 17β-Estradiol-Mediated Resistance to Apoptosis by Differentially Modulating Classic and Nonclassic Estrogen Receptors in Breast Cancer Cells

Scientists investigated whether Newcastle disease virus (NDV)‐D90, a novel strain isolated from natural sources in China, promoted apoptosis by modulating the expression of ERα or the GPER in breast cancer cells exposed to 17β‐estradiol.
[Journal of Cellular Biochemistry]
NDV‐D90 inhibits 17β‐estradiol‐mediated resistance to apoptosis by differentially modulating classic and nonclassic estrogen receptors in breast cancer cells - Shan - - Journal of Cellular Biochemistry - Wiley Online Library. (n.d.). Retrieved September 29, 2020, from https://onlinelibrary.wiley.com/doi/10.1002/jcb.28118 Cite
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6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling

Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.
[Molecules]
Liu, R., Choi, H. S., Kim, S.-L., Kim, J.-H., Yun, B.-S., & Lee, D.-S. (2020). 6-Methoxymellein Isolated from Carrot (Daucus carota L.) Targets Breast Cancer Stem Cells by Regulating NF-κB Signaling. Molecules, 25(19), 4374. https://doi.org/10.3390/molecules25194374 Cite
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Upregulation of S100A10 in Metastasized Breast Cancer Stem Cells

Knockdown of S100A10 in breast cancer cells suppressed and overexpression of S100A10 in breast cancer patient‐derived tumor xenograft cells enhanced their invasion abilities and 3D organoid formation capacities in vitro.
[Cancer Science]
Yanagi, H., Watanabe, T., Nishimura, T., Hayashi, T., Kono, S., Tsuchida, H., Hirata, M., Kijima, Y., Takao, S., Okada, S., Suzuki, M., Imaizumi, K., Kawada, K., Minami, H., Gotoh, N., & Shimono, Y. (n.d.). Upregulation of S100A10 in metastasized breast cancer stem cells. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14659 Cite
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Introduction of hsa-MiR-512-3p as a New Regulator of HER2 Signaling Pathway in Breast Cancer

Researchers found that miR-512-3p acted as a cell-type-specific tumor suppressor, through targeting HER2, HER3, PIK3R2, and AKT1 transcripts.
[Breast Cancer Research and Treatment]
Mohamadzade, Z., Mahjoubi, F., & Soltani, B. M. (2020). Introduction of hsa-miR-512-3p as a new regulator of HER2 signaling pathway in breast cancer. Breast Cancer Research and Treatment. https://doi.org/10.1007/s10549-020-05937-3 Cite
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Annurca Apple Polyphenol Extract Promotes Mesenchymal-to-Epithelial Transition and Inhibits Migration in Triple-Negative Breast Cancer Cells through ROS/JNK Signaling

By qualitatively and quantitatively monitoring the real-time movements of live cells researchers provided the first evidence that pple polyphenol extract inhibited the migration of MDA-MB-231 and MDA-MB-468 TNBC cells and downregulated metalloproteinase-2 and metalloproteinase-9.
[Scientific Reports]
Vuoso, D. C., D’Angelo, S., Ferraro, R., Caserta, S., Guido, S., Cammarota, M., Porcelli, M., & Cacciapuoti, G. (2020). Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling. Scientific Reports, 10(1), 15921. https://doi.org/10.1038/s41598-020-73092-2 Cite
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Ambrisentan, an Endothelin Receptor Type A-Selective Antagonist, Inhibits Cancer Cell Migration, Invasion, and Metastasis

In vitro, Ambrisentan inhibited both spontaneous and induced migration/invasion capacity of different tumor cells. Whole transcriptome analysis using RNAseq indicated Ambrisentan’s inhibitory effects on the whole transcriptome of resting and PAR2-activated COLO-357 cells, which tended to normalize to an unstimulated profile.
[Scientific Reports]
Kappes, L., Amer, R. L., Sommerlatte, S., Bashir, G., Plattfaut, C., Gieseler, F., Gemoll, T., Busch, H., Altahrawi, A., Al-Sbiei, A., Haneefa, S. M., Arafat, K., Schimke, L. F., Khawanky, N. E., Schulze-Forster, K., Heidecke, H., Kerstein-Staehle, A., Marschner, G., Pitann, S., … Cabral-Marques, O. (2020). Ambrisentan, an endothelin receptor type A-selective antagonist, inhibits cancer cell migration, invasion, and metastasis. Scientific Reports, 10(1), 15931. https://doi.org/10.1038/s41598-020-72960-1 Cite
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ARe We There Yet? Understanding Androgen Receptor Signaling in Breast Cancer

As both prostate and breast cancers often share a reliance on nuclear hormone signaling, there is increasing appreciation of the overlap between activated cellular pathways in these cancers in response to androgen signaling.
[npj Breast Cancer]
Michmerhuizen, A. R., Spratt, D. E., Pierce, L. J., & Speers, C. W. (2020). ARe we there yet? Understanding androgen receptor signaling in breast cancer. Npj Breast Cancer, 6(1), 1–19. https://doi.org/10.1038/s41523-020-00190-9 Cite
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Multi-Omics Analyses Identify HSD17B4

HSD17B4 was highly expressed in the vast majority of human cancers, and its methylation was present only in breast cancers and one lymphoblastic leukemia cell line.
[Scientific Reports]
Yamashita, S., Hattori, N., Fujii, S., Yamaguchi, T., Takahashi, M., Hozumi, Y., Kogawa, T., El-Omar, O., Liu, Y.-Y., Arai, N., Mori, A., Higashimoto, H., Ushijima, T., & Mukai, H. (2020). Multi-omics analyses identify HSD17B4 methylation-silencing as a predictive and response marker of HER2-positive breast cancer to HER2-directed therapy. Scientific Reports, 10(1), 15530. https://doi.org/10.1038/s41598-020-72661-9 Cite
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Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

Investigators report that Furin was frequently overexpressed in TNBC tumors and this correlated with poor prognosis in patients with TNBC tumors.
[Cancers]
He, Z., Khatib, A.-M., & Creemers, J. W. M. (2020). Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer. Cancers, 12(9), 2686. https://doi.org/10.3390/cancers12092686 Cite
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Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer

Scientists tested the effectiveness of a novel class of 1,1-diarylethylene FOXM1 inhibitory compounds in suppressing TNBC cell migration, invasion, and metastasis using in vitro cell culture and in vivo tumor models.
[Cancers]
Dey, P., Wang, A., Ziegler, Y., Kim, S. H., El-Ashry, D., Katzenellenbogen, J. A., & Katzenellenbogen, B. S. (2020). Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer. Cancers, 12(9), 2677. https://doi.org/10.3390/cancers12092677 Cite
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Short Term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor Positive Breast Cancers

Researchers sought to understand the effects of CDK4/6 inhibition and radiation in multiple preclinical breast cancer models.
[Clinical Cancer Research]
Pesch, A. M., Hirsh, N., Chandler, B. C., Michmerhuizen, A. R., Ritter, C. L., Androsiglio, M., Wilder-Romans, K., Liu, M., Gersch, C., Larios, J. M., Pierce, L. J., Rae, J. M., & Speers, C. (2020). Short Term CDK4/6 Inhibition Radiosensitizes Estrogen Receptor Positive Breast Cancers. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-2269 Cite
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