Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
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Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Circulating Tumor Cell Number and Endocrine Therapy Index in ER Positive Metastatic Breast Cancer Patients

Circulating tumor cells enumeration at initiation of endocrine therapy (ET), and at early and following time points was prognostic in ER-positive metastatic breast cancer starting second-line or later ET.
[npj Breast Cancer]
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Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
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Metabolic Perturbations Sensitize Triple-Negative Breast Cancers to Apoptosis Induced by BH3 Mimetics

The authors investigated the metabolic vulnerabilities of TNBC, particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics.
[Science Signaling]
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Combined Inhibition of DDR1 and CDK4/6 Induces Synergistic Effects in ER-Positive, HER2-Negative Breast Cancer with PIK3CA/AKT1 Mutations

DDR1 knockdown and DDR1 pharmacological inhibitor decreased cell growth and inhibited cell cycle progression in breast cancer cell lines, while enhanced the sensitivity of PIK3CA/AKT1 mutant cells to palbociclib.
[Oncogene]
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Antibody-Drug Conjugates with Dual Payloads for Combating Breast Tumor Heterogeneity and Drug Resistance

Scientists created homogeneous antibody-drug conjugates containing two distinct payloads that showed HER2-specific cell killing potency, desirable pharmacokinetic profiles, minimal inflammatory response, and marginal toxicity at therapeutic doses.
[Nature Communications]
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Long Noncoding RNAs in Triple-Negative Breast Cancer: A New Frontier in the Regulation of Tumorigenesis

The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
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Byondis Announces Positive Topline Results of Pivotal Phase III TULIP® Study in Patients With HER2-Positive Unresectable Locally Advanced or Metastatic Breast Cancer

Byondis B.V. announced positive results from the Phase III TULIP® study. The trial compared the efficacy and safety of the company’s antibody-drug conjugate [vic-]trastuzumab duocarmazine to physician’s choice treatment in patients with pretreated HER2-positive unresectable locally advanced or metastatic breast cancer.
[Byondis B.V.]
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Mechano-Induced Cell Metabolism Promotes Microtubule Glutamylation to Force Metastasis

Researchers showed that matrix stiffening rewired glutamine metabolism to promote microtubules (MT) glutamylation and force MT stabilization, thereby promoting cell invasion.
[Cell Metabolism]
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Genetic Variation Associated with Thyroid Autoimmunity Shapes the Systemic Immune Response to PD-1 Checkpoint Blockade

The authors studied endocrine immune related adverse events from seven clinical trials across six cancers where atezolizumab was combined with chemotherapies and compared to standard of care.
[Nature Communications]
Khan, Z., Hammer, C., Carroll, J., Di Nucci, F., Acosta, S. L., Maiya, V., Bhangale, T., Hunkapiller, J., Mellman, I., Albert, M. L., McCarthy, M. I., & Chandler, G. S. (2021). Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade. Nature Communications, 12(1), 3355. https://doi.org/10.1038/s41467-021-23661-4 Cite
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