Incorporation of Docetaxel and Thymoquinone in Borage Nanoemulsion Potentiates Their Antineoplastic Activity in Breast Cancer Cells

Scientists formulated docetaxel and thymoquinone in borage oil-based nanoemulsion and evaluated its potential in impeding the growth of breast cancer cells.
[Scientific Reports]
Alkhatib, M. H., Bawadud, R. S., & Gashlan, H. M. (2020). Incorporation of docetaxel and thymoquinone in borage nanoemulsion potentiates their antineoplastic activity in breast cancer cells. Scientific Reports, 10(1), 18124. https://doi.org/10.1038/s41598-020-75017-5 Cite
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Identification of Drivers of Breast Cancer Invasion by Secretome Analysis: Insight Into CTGF Signaling

Scientists combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
[Scientific Reports]
Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling | Scientific Reports. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41598-020-74838-8 Cite
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The Molecular Basis of Mammary Gland Development and Epithelial Differentiation

Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.
[Seminars in Cell & Developmental Biology]
Slepicka, P. F., Somasundara, A. V. H., & dos Santos, C. O. (2020). The molecular basis of mammary gland development and epithelial differentiation. Seminars in Cell & Developmental Biology. https://doi.org/10.1016/j.semcdb.2020.09.014 Cite
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Mesenchymal Stem Cells-Secreted Exosome Promotes Chemoresistance in Breast Cancer via Enhancing miR-21-5p-Mediated S100A6 Expression

The authors investigated the effect of a standard of care chemotherapeutic agent Doxorubicin (Dox) on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). They found that the exosome secreted by Dox-treated MSC induced a higher degree of Dox resistance in BCs when compared with non-treated MSC-exo.
[Molecular Therapy-Oncolytics]
Luo, T., Liu, Q., Tan, A., Duan, L., Jia, Y., Nong, L., Tang, J., Zhou, W., Xie, W., Lu, Y., Yu, Q., & Liu, Y. (2020). Mesenchymal stem cells-secreted exosome promotes chemoresistance in breast cancer via enhancing miR-21-5p-mediated S100A6 expression. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.10.008 Cite
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Matrix Pore Size Governs Escape of Human Breast Cancer Cells from a Microtumor to an Empty Cavity

By varying the physical properties of collagen, investigators found that MDA-MB-231 tumor cells invaded and escaped faster in lower-density ECM. These effects were mediated by the ECM pore size, rather than by the elastic modulus or interstitial flow speed.
[iScience]
Tien, J., Ghani, U., Dance, Y. W., Seibel, A. J., Karakan, M. C., Ekinci, K. L., & Nelson, C. M. (2020). Matrix pore size governs escape of human breast cancer cells from a microtumor to an empty cavity. IScience, 0(0). https://doi.org/10.1016/j.isci.2020.101673 Cite
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EZH2 Regulates Expression of FOXC1 by Mediating H3K27me3 in Breast Cancers

Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Zheng, X., Li, W., Yi, J., Liu, J., Ren, L., Zhu, X., Liu, S., Wang, J., & Du, G. (2020). EZH2 regulates expression of FOXC1 by mediating H3K27me3 in breast cancers. Acta Pharmacologica Sinica, 1–9. https://doi.org/10.1038/s41401-020-00543-x Cite
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OSR1 Phosphorylates the Smad2/3 Linker Region and Induces TGF-β1 Autocrine to Promote EMT and Metastasis in Breast Cancer

Interruption of the Oxidative stress-responsive kinase 1 (OSR1)-Smad2/3-TGF-β1 signaling axis elicited a robust anti-EMT and anti-metastatic effect in vitro and in vivo.
[Oncogene]
Li, Y., Li, L., Qin, J., Wu, J., Dai, X., & Xu, J. (2020). OSR1 phosphorylates the Smad2/3 linker region and induces TGF-β1 autocrine to promote EMT and metastasis in breast cancer. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01499-2 Cite
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Long Noncoding RNA FGF14-AS2 Inhibits Breast Cancer Metastasis by Regulating the miR-370-3p/FGF14 Axis

Investigators elucidated the potential role of a novel lncRNA FGF14-AS2 and the mechanisms underlying metastasis in breast cancer.
[Cell Death Discovery]
Jin, Y., Zhang, M., Duan, R., Yang, J., Yang, Y., Wang, J., Jiang, C., Yao, B., Li, L., Yuan, H., Zha, X., & Ma, C. (2020). Long noncoding RNA FGF14-AS2 inhibits breast cancer metastasis by regulating the miR-370-3p/FGF14 axis. Cell Death Discovery, 6(1), 1–14. https://doi.org/10.1038/s41420-020-00334-7 Cite
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Inhibition of O-GlcNAc Transferase Activates Tumor-Suppressor Gene Expression in Tamoxifen-Resistant Breast Cancer Cells

Researchers probed the importance of O-GlcNAc transferase activity for the survival of tamoxifen-sensitive and tamoxifen-resistant breast cancer cells.
[Scientific Reports]
Barkovskaya, A., Seip, K., Prasmickaite, L., Mills, I. G., Moestue, S. A., & Itkonen, H. M. (2020). Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Scientific Reports, 10(1), 16992. https://doi.org/10.1038/s41598-020-74083-z Cite
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The Amino-Terminal Oligomerization Domain of Angiopoietin-2 Affects Vascular Remodeling, Mammary Gland Tumor Growth, and Lung Metastasis in Mice

Scientists used a knock-in mouse line, a genetic model for breast cancer and metastasis, a syngeneic melanoma lung colonization model, and orthotopic injection of E0771 breast cancer cells to show that alternative forms increased the diversity of Angiopoietin-2 function.
[Cancer Research]
Kapiainen, E., Kihlström, M. K., Pietilä, R., Kaakinen, M., Ronkainen, V.-P., Tu, H., Heikkinen, A., Devarajan, R., Miinalainen, I., Laitakari, A., Ansarizadeh, M., Zhang, Q., Wei, G.-H., Ruddock, L., Pihlajaniemi, T., Elamaa, H., & Eklund, L. (2020). The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-1904 Cite
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PRRG4 Promotes Breast Cancer Metastasis Through the Recruitment of NEDD4 and Downregulation of Robo1

Researchers uncovered that the transmembrane proline rich γ-carboxyglutamic acid protein 4 (PRRG4) promoted breast cancer metastasis by downregulating Robo1.
[Oncogene]
Zhang, L., Qin, Y., Wu, G., Wang, J., Cao, J., Wang, Y., Wu, D., Yang, K., Zhao, Z., He, L., Lyu, J., Li, H., & Gu, H. (2020). PRRG4 promotes breast cancer metastasis through the recruitment of NEDD4 and downregulation of Robo1. Oncogene, 1–13. https://doi.org/10.1038/s41388-020-01494-7 Cite
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