Scientists formulated docetaxel and thymoquinone in borage oil-based nanoemulsion and evaluated its potential in impeding the growth of breast cancer cells.
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Scientists combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
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Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling | Scientific Reports. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41598-020-74838-8 Cite
Investigators provide an overview of the latest research in the single-cell genomics of mammary gland development, which may help to understand the lineage commitment of mammary stem cells into luminal or basal epithelial cells that constitute the mammary gland.
[Seminars in Cell & Developmental Biology]
The authors investigated the effect of a standard of care chemotherapeutic agent Doxorubicin (Dox) on MSC-exo and its contribution to the development of Dox resistance in breast cancer cells (BCs). They found that the exosome secreted by Dox-treated MSC induced a higher degree of Dox resistance in BCs when compared with non-treated MSC-exo.
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Luo, T., Liu, Q., Tan, A., Duan, L., Jia, Y., Nong, L., Tang, J., Zhou, W., Xie, W., Lu, Y., Yu, Q., & Liu, Y. (2020). Mesenchymal stem cells-secreted exosome promotes chemoresistance in breast cancer via enhancing miR-21-5p-mediated S100A6 expression. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.10.008 Cite
By varying the physical properties of collagen, investigators found that MDA-MB-231 tumor cells invaded and escaped faster in lower-density ECM. These effects were mediated by the ECM pore size, rather than by the elastic modulus or interstitial flow speed.
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Scientists demonstrated that the expression of FOXC1 was associated with resistance of doxorubicin treatment of breast cancer cells.
[Acta Pharmacologica Sinica]
Interruption of the Oxidative stress-responsive kinase 1 (OSR1)-Smad2/3-TGF-β1 signaling axis elicited a robust anti-EMT and anti-metastatic effect in vitro and in vivo.
Investigators elucidated the potential role of a novel lncRNA FGF14-AS2 and the mechanisms underlying metastasis in breast cancer.
[Cell Death Discovery]
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Jin, Y., Zhang, M., Duan, R., Yang, J., Yang, Y., Wang, J., Jiang, C., Yao, B., Li, L., Yuan, H., Zha, X., & Ma, C. (2020). Long noncoding RNA FGF14-AS2 inhibits breast cancer metastasis by regulating the miR-370-3p/FGF14 axis. Cell Death Discovery, 6(1), 1–14. https://doi.org/10.1038/s41420-020-00334-7 Cite
Researchers probed the importance of O-GlcNAc transferase activity for the survival of tamoxifen-sensitive and tamoxifen-resistant breast cancer cells.
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Barkovskaya, A., Seip, K., Prasmickaite, L., Mills, I. G., Moestue, S. A., & Itkonen, H. M. (2020). Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells. Scientific Reports, 10(1), 16992. https://doi.org/10.1038/s41598-020-74083-z Cite
Scientists used a knock-in mouse line, a genetic model for breast cancer and metastasis, a syngeneic melanoma lung colonization model, and orthotopic injection of E0771 breast cancer cells to show that alternative forms increased the diversity of Angiopoietin-2 function.
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Kapiainen, E., Kihlström, M. K., Pietilä, R., Kaakinen, M., Ronkainen, V.-P., Tu, H., Heikkinen, A., Devarajan, R., Miinalainen, I., Laitakari, A., Ansarizadeh, M., Zhang, Q., Wei, G.-H., Ruddock, L., Pihlajaniemi, T., Elamaa, H., & Eklund, L. (2020). The amino-terminal oligomerization domain of Angiopoietin-2 affects vascular remodeling, mammary gland tumor growth, and lung metastasis in mice. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-19-1904 Cite
Researchers uncovered that the transmembrane proline rich γ-carboxyglutamic acid protein 4 (PRRG4) promoted breast cancer metastasis by downregulating Robo1.
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