USP35, Regulated by Estrogen and AKT, Promotes Breast Tumorigenesis by Stabilizing and Enhancing Transcriptional Activity of Estrogen Receptor α

USP35 promoted the growth of ER+ breast cancer in vitro and in vivo, and reduced the sensitivity of ER+ breast cancer cells to endocrine therapies such as tamoxifen and fulvestrant.
[Cell Death & Disease]
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Utilizing the Hippo Pathway as a Therapeutic Target for Combating Endocrine-Resistant Breast Cancer

Scientists explain the possible mechanism of the Hippo pathway in combating endocrine resistance, and conclude by recommending endocrine therapy in combination with therapies targeting the Hippo pathway in the study of endocrine-resistant breast cancers.
[Cancer Cell International]
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A Time-Course Raman Spectroscopic Analysis of Spontaneous In Vitro Microcalcifications in a Breast Cancer Cell Line

Using a previously established model of in vitro mineralization, the MDA-MB-231 human breast cancer cell line was induced using two osteogenic agents, inorganic phosphate and β-glycerophosphate, and direct monitoring of the mineralization process was conducted using Raman micro-spectroscopy.
[Laboratory Investigation]
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Single and Double Modified Salinomycin Analogs Target Stem-Like Cells in 2D and 3D Breast Cancer Models

A library of 17 C1-single and C1/C20-double modified salinomycin analogs was screened to identify compounds with improved activity against breast cancer stem cells.
[Biomedicine & Pharmacotherapy]
Urbaniak, A., Reed, M. R., Fil, D., Moorjani, A., Heflin, S., Antoszczak, M., Sulik, M., Huczyński, A., Kupsik, M., Eoff, R. L., MacNicol, M. C., Chambers, T. C., & MacNicol, A. M. (2021). Single and double modified salinomycin analogs target stem-like cells in 2D and 3D breast cancer models. Biomedicine & Pharmacotherapy, 141, 111815. https://doi.org/10.1016/j.biopha.2021.111815 Cite
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Carcinoma-Associated Fibroblasts Derived Exosomes Modulate Breast Cancer Cell Stemness through Exonic circHIF1A by miR-580-5p in Hypoxic Stress

Through investigating cellular functions including cell proliferation and stem cell features, it was demonstrated that hypoxic cancer-associated fibroblasts exosomes transferred circHIF1A into breast cancer cells, which played an important role in cancer stem cell properties sponging miR-580-5p by regulating CD44 expression.
[Cell Death Discovery]
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Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis

Researchers explored whether the microbiome of the gut and mammary gland mediates the dietary effects on breast cancer. In vitro models of the normal breast epithelium showed that lipopolysaccharide disrupted tight junctions and compromised epithelial permeability.
[Cancer Research]
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PELP1/Src-3-Dependent Regulation of Metabolic Pfkfb Kinases Drives Therapy Resistant Er+ Breast Cancer

Researchers showed that cytoplasmic complexes composed of steroid receptor co-activators, PELP1 and SRC-3, modulated breast cancer stem cell expansion through upregulation of the HIF-activated metabolic target genes PFKFB3 and PFKFB4.
[Oncogene]
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Aging and CNS Myeloid Cell Depletion Attenuate Breast Cancer Brain Metastasis

Old and young mouse brains, metastatic and naïve, were analyzed by flow cytometry. Immune populations were depleted using antibodies or a colony stimulating factor-1 receptor (CSF-1R) inhibitor, and brain metastasis assays were conducted.
[Clinical Cancer Research]
Wu, A. M. L., Gossa, S., Samala, R., Chung, M. A., Gril, B., Yang, H., Thorsheim, H. R., Tran, A. D., Wei, D., Taner, E., Isanogle, K., Yang, Y., Dolan, E. L., Robinson, C. M., Difilippantonio, S., Lee, M., Khan, I., Smith, Q. R., McGavern, D. B., … Steeg, P. S. (2021). Aging and CNS myeloid cell depletion attenuate breast cancer brain metastasis. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-1549 Cite
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Radium-223-Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow

To understand how 223RaCl2, an alpha particle emitting radiopharmaceutical, affects the growth delay of disseminated tumor cells, scientists quantified the biological changes caused by direct effects of radiation and bystander effects caused by the emitted radiations on mammary tumor cells.
[Molecular Cancer Research]
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LncRNA PART1 Promotes Proliferation and Migration, Is Associated with Cancer Stem Cells, and Alters the miRNA Landscape in Triple-Negative Breast Cancer

Researchers demonstrated that long non-coding RNA prostate androgen regulated transcript 1 (PART1) was enriched in TNBCs. Knockdown of PART1 in TNBC cell lines and a patient-derived xenograft decreased cell proliferation, migration, tumor growth, and mammosphere formation potential.
[Cancers]
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Peptide-Tiling Screens of Cancer Drivers Reveal Oncogenic Protein Domains and Associated Peptide Inhibitors

Pooled fitness screens in two breast cancer cell lines revealed peptides, which selectively reduced cellular proliferation, implicating oncogenic protein domains important for cell fitness.
[Cell Systems]
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