breast cancer stem cells

[Cancers] Researchers found that ZFHX3 promoted the proliferation and tumor growth of breast cancer cells in culture and nude mice; and higher expression of ZFHX3 in human breast cancer specimens was associated with poorer prognosis.

[PLoS One] Human CD24-/CD44+ breast cancer stem cells (BCSCs) were treated with andrographolide in vitro for 24 hours. The cytotoxic effect of andrographolide on BCSCs was compared to that on human mesenchymal stem cells.

[Scientific Reports] Researchers evaluated the ex vivo response of patient tumor-derived organoids (or mammospheres) to chemotherapy alone or in combination with P2Et. A xenotransplant model engrafted with MDA-MB-468 was used to evaluate in vivo the activity of P2Et, in this model P2Et delay tumor growth.

[Scientific Reports] Investigators evaluated the presence of breast cancer stem cells as well as markers related to drug resistance in tumors obtained from 78 patients who had received (or not) chemotherapy before surgery.

[Journal of Cellular Biochemistry] The authors investigated the cellular energetics of two triple‐negative breast cancer stem cells treated with two pharmacological doses of vitamin C that generated reactive oxygen species.

[Molecules] Methanol extracts of carrot root were purified by means of silica gel, Sephadex LH-20, and preparative high-performance liquid chromatography to isolate a compound targeting mammosphere formation.