cancer stem cells

[Journal For Immunotherapy of Cancer] Human and murine breast CSCs were tested for their production of and response to IL30 by using flow cytometry, confocal microscopy, proliferation and sphere-formation assays, and PCR array.

[Journal of Cancer] Investigators evaluated programmed cell death ligand-1 (PD-L1) expression in colorectal CSCs (CCSCs) and non-CCSCs and designed a combination immunotherapy synchronously utilizing PD-L1-CAR-T cells together with CCSC-dendritic cells vaccine-sensitized T cells for the treatment of colorectal cancer.

[Expert Opinion On Therapeutic Targets] Investigators discuss the challenges of targeting the Wnt signaling cascade, the safety, efficacy, and therapeutic potential of specific CBP/β-catenin antagonists and a rationale for the pleiotropic effects of CBP/β-catenin antagonists beyond Wnt signaling.

[Theranostics] Lung cancer patient-derived cancer cell and cancer-associated fibroblasts were utilized to mimic the tumor microenvironment and reproduced the stemness properties of cancer stem cells in vitro and developed a high-throughput drug screening platform with phenotypical parameters.

[Biomedicine & Pharmacotherapy] The extract of A. cherimola showed the highest antioxidant activity and M. oleifera had the highest capacity to enhance the activity of detoxifying enzymes such as glutathione S-transferase and quinone oxidoreductase.

[Cell Reports] Researchers used marker-independent stochastic clonal labeling, combined with quantitative modeling of tumor expansion, to uncover pancreatic ductal adenocarcinoma tissue growth dynamics.