Synergistic Killing Effects of PD-L1-CAR T Cells and Colorectal Cancer Stem Cell-Dendritic Cell Vaccine-Sensitized T Cells in ALDH1-Positive Colorectal Cancer Stem Cells

Investigators evaluated programmed cell death ligand-1 (PD-L1) expression in colorectal CSCs (CCSCs) and non-CCSCs and designed a combination immunotherapy synchronously utilizing PD-L1-CAR-T cells together with CCSC-dendritic cells vaccine-sensitized T cells for the treatment of colorectal cancer.