PD-L1

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

[Nature Communications] The authors showed that broadening the number of neoantigen-reactive CD8+ T cell populations between pre-treatment to three weeks post-treatment distinguished patients with controlled disease compared to patients with progressive disease in metastatic urothelial carcinoma treated with PD-L1-blockade.

[Nature Communications] Scientists showed that depletion of stromal antigen 2 (STAG2) in melanoma cells led to the expansion of topologically associating domains and enhanced the formation of acetylated histone H3 lysine 27.

[Nature Communications] Investigators examined tumor-immune eco-evolutionary dynamics from pre-cancer to carcinoma using a computational model, ecological analysis of digital pathology data, and neoantigen prediction in 62 patient samples.

[Nature Communications] Scientists profiled 54,103 cells from tumor and adjacent tissues to characterize cellular composition and elucidated the potential origin and regulation of tumor-enriched cell types in colorectal cancer.

[Cancer Immunology Immunotherapy] In an in vitro study using lung cancer cell lines and human monocyte-derived macrophages, the conditioned medium from cancer cells was found to up-regulate programmed cell death-1 ligand 1 expression on macrophages via STAT3 activation.