Novel Long Noncoding RNAs Upregulation May Have Synergistic Effects on the CYP24A1 and PFDN4 Biomarker Role in Human Colorectal Cancer

Investigators surveyed the expression levels and clinical significance of novel long noncoding RNAs related to CYP24A1 and PFDN4 genes in colorectal cancer using real‐time polymerase chain reaction. They also assessed the expression of these genes after vitamin D treatment in HCT‐116 and HT‐29 colon cancer cell lines.
[Journal of Cellular Physiology]
Sadeghi, H., Nazemalhosseini‐Mojarad, E., Sahebi, U., Fazeli, E., Azizi‐Tabesh, G., Yassaee, V. R., Savabkar, S., Aghdaei, H. A., Zali, M. R., & Mirfakhraie, R. (n.d.). Novel long noncoding RNAs upregulation may have synergistic effects on the CYP24A1 and PFDN4 biomarker role in human colorectal cancer. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.29992 Cite
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Ciclopirox Activates PERK-Dependent Endoplasmic Reticulum Stress to Drive Cell Death in Colorectal Cancer

Scientists report that ciclopirox exhibited strong antitumorigenic properties in colorectal cancer by inducing cell cycle arrest, repressing cell migration, and invasion by affecting N-cadherin, Snail, E-cadherin, MMP-2, and MMP-9 expression. Disruption of cellular bioenergetics contributed to ciclopirox-associated inhibition of cell growth, migration, and invasion.
[Cell Death & Disease]
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Continuous Formation of Small Clusters with LGR5-Positive Cells Contributes to Tumor Growth in a Colorectal Cancer Xenograft Model

Investigators evaluated the growth of moderate differentiated colorectal cancer from LGR5-positive cells, which was a cancer stem cell marker of colorectal cancer, using xenograft and three-dimensional culture models spatiotemporally.
[Laboratory Investigation]
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Src Family Tyrosine Kinases in Intestinal Homeostasis, Regeneration and Tumorigenesis

The authors review recent findings on Src family kinase (SFK) signalling during intestinal homeostasis, regeneration and tumorigenesis. They also describe the key nongenetic mechanisms underlying SFK tumour activities in colorectal cancer, and discuss how these mechanisms could be exploited in therapeutic strategies to target SFK signalling in metastatic colon cancer.
[Cancers]
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Signatures of Co-deregulated Genes and Their Transcriptional Regulators in Colorectal Cancer

Researchers reanalyzed 19 GEO gene expression profiles to identify and annotate colorectal cancer versus normal signatures, single-gene perturbation, and single-drug perturbation signatures.
[npj Systems Biology and Applications]
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Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer

The authors demonstrated that the Hippo kinases LATS1/2 and MST1/2, which inhibited YAP activity, were required for maintaining Wnt signaling and canonical stem cell function.
[Cell Stem Cell]
Cheung, P., Xiol, J., Dill, M. T., Yuan, W.-C., Panero, R., Roper, J., Osorio, F. G., Maglic, D., Li, Q., Gurung, B., Calogero, R. A., Yilmaz, Ö. H., Mao, J., & Camargo, F. D. (2020). Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer. Cell Stem Cell, 0(0). https://doi.org/10.1016/j.stem.2020.07.003 Cite
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miR-3622a-3p Acts as a Tumor Suppressor in Colorectal Cancer by Reducing Stemness Features and EMT through Targeting Spalt-Like Transcription Factor 4

The effect of miR-3622a-3p on proliferation, apoptosis, cell cycle, migration and invasion of colorectal cancer (CRC) cells were investigated by a series of biological function assays and the results revealed that miR-3622a-3p could inhibit the malignant biological properties of CRC.
[Cell Death & Disease]
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Circular RNA circCTNNA1 Promotes Colorectal Cancer Progression by Sponging miR-149-5p and Regulating FOXM1 Expression

circCTNNA1 promoted colon cancer cell proliferation, migration, and invasion in vitro and in vivo. It could serve as a competing endogenous RNA of miR-149-5p to counteract the suppressive effect of miR-149-5p on downstream target Forkhead Box M1.
[Cell Death & Disease]
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LASP1 Interacts with N-WASP to Activate the Arp2/3 Complex and Facilitate Colorectal Cancer Metastasis by Increasing Tumour Budding and Worsening the Pattern of Invasion

Investigators suggested a new mechanism for LIM and SH3 protein 1(LASP1)-mediated colorectal cancer metastasis determined by exploring LASP1-interacting proteins, and identified N–Wiskott–Aldrich syndrome protein as a potential therapeutic target for colorectal cancer.
[Oncogene]
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PI3K-Targeting Strategy Using Alpelisib to Enhance the Antitumor Effect of Paclitaxel in Human Gastric Cancer

The authors investigated the anti-tumor effects of alpelisib, a PI3K p110α-specific inhibitor, using preclinical models of gastric cancer. The combined effects of alpelisib and paclitaxel on gastric cancer was also evaluated.
[Scientific Reports]
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Copper Bioavailability Is a KRAS-Specific Vulnerability in Colorectal Cancer

ATP7A regulates the intracellular copper levels and tumor growth in KRAS-transformed cells. Investigators demonstrated that inhibiting Copper supply was an attractive therapeutic option for KRAS-mutant cells.
[Nature Communications]
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Upregulation of OSBPL3 by HIF1A Promotes Colorectal Cancer Progression through Activation of RAS Signaling Pathway

Scientists investigated the role of oxysterol-binding protein like protein 3 in colorectal cancer and found that its expression was significantly higher in colorectal cancer tissues than that in normal tissues.
[Cell Death & Disease]
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