colorectal cancer

[Molecular and Cellular Biochemistry] The combined chemotherapy with methionine restriction could enhance the chemotherapeutic sensitivity of colorectal cancer stem cells by up-regulation of miR-320d to inhibit c-Myc expression

[Oncogene] Scientists performed a synthetic lethal drug screening with SMAD4-isogenic colorectal cancer cells and found that aurora kinase A inhibition is synthetic lethal with SMAD4 loss.

[Nature Communications] Investigators showed that the aryl hydrocarbon receptor was important for the termination of the regenerative response and the reacquisition of mature epithelial cell identity post injury in vivo and in organoid cultures in vitro.

[Biochemical and Biophysical Research Communications] Scientists found that the expression of miR-1538 was significantly down-regulated in colorectal cancer tissues and cells, and its expression level was significantly correlated with tumor size, clinical stage and prognosis.

[Experimental Cell Research] The authors found that high ZIC2 expression was not only associated with poor prognosis, relapse-free survival and advanced metastasis but was also an independent prognostic factor in colorectal cancer patients.

[Frontiers in Oncology] Investigators summarize current knowledge on the molecular network of colorectal cancer (CRC), including cellular signaling pathways, CRC microenvironment modulation, epigenetic changes, and CRC biomarkers for diagnosis and predictive/prognostic use.