Researchers showed that an iPSC-based cancer vaccine, comprised of autologous iPSCs and CpG, stimulated cytotoxic antitumor CD8+ T cell effector and memory responses, induced cancer-specific humoral immune responses, reduced immunosuppressive CD4+ T regulatory cells, and prevented tumor formation in 75% of pancreatic ductal adenocarcinoma mice.
[Stem Cell Reports]
6445218 WT3HH7P6 items 1 apa default asc 1
Ouyang, X., Liu, Y., Zhou, Y., Guo, J., Wei, T.-T., Liu, C., Lee, B., Chen, B., Zhang, A., Casey, K. M., Wang, L., Kooreman, N. G., Habtezion, A., Engleman, E. G., & Wu, J. C. (2021). Antitumor effects of iPSC-based cancer vaccine in pancreatic cancer. Stem Cell Reports, 0(0). https://doi.org/10.1016/j.stemcr.2021.04.004 Cite
By tracking individual cells in the skin of live adult mice over time, investigators showed that Langerhans cells and dendritic epidermal T cells actively maintained a non-random spatial distribution despite continuous turnover of neighbouring basal epithelial cells.
[Nature Cell Biology]
6445212 ZF6VHN76 items 1 apa default asc 1
Park, S., Matte-Martone, C., Gonzalez, D. G., Lathrop, E. A., May, D. P., Pineda, C. M., Moore, J. L., Boucher, J. D., Marsh, E., Schmitter-Sánchez, A., Cockburn, K., Markova, O., Bellaïche, Y., & Greco, V. (2021). Skin-resident immune cells actively coordinate their distribution with epidermal cells during homeostasis. Nature Cell Biology, 1–9. https://doi.org/10.1038/s41556-021-00670-5 Cite
Investigators demonstrated that T cell phenotypic signatures associate with viral reservoir size in a cohort of HIV vertically infected children and young adults under durable viral control, and who initiated anti-retroviral therapy under two years old.
6445212 KTML855P items 1 apa default asc 1
Rinaldi, S., Armas, L. de, Dominguez-Rodríguez, S., Pallikkuth, S., Dinh, V., Pan, L., Gӓrtner, K., Pahwa, R., Cotugno, N., Rojo, P., Nastouli, E., Klein, N., Foster, C., Rossi, A. D., Giaquinto, C., Rossi, P., Palma, P., & Consortium, on behalf of E. (2021). T cell immune discriminants of HIV reservoir size in a pediatric cohort of perinatally infected individuals. PLOS Pathogens, 17(4), e1009533. https://doi.org/10.1371/journal.ppat.1009533 Cite
Investigators assessed the magnitude, function and phenotype of SARS-CoV-2-specific CD4 T cells in 95 hospitalized COVID-19 patients and 38 non-COVID-19 patients, using flow cytometry.
[Journal of Clinical Investigation]
6445212 AUF3S6GX items 1 apa default asc 1
Riou, C., Bruyn, E. D., Stek, C., Daroowala, R., Goliath, R. T., Abrahams, F., Said-Hartley, Q., Allwood, B. W., Hsiao, N.-Y., Wilkinson, K. A., Arlehamn, C. S. L., Sette, A., Wasserman, S., & Wilkinson, R. J. (2021). Relationship of SARS-CoV-2-specific CD4 response to COVID-19 severity and impact of HIV-1 and Tuberculosis co-infection. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI149125 Cite
The stellar successes of immunotherapies that harness the power of T cells to treat solid tumors and an improved understanding of the immune systems of patients with hematologic malignancies have led to major efforts to develop immunotherapies for the treatment of patients with AML.
Investigators showed that in peanut-allergic humans, peanut allergen drives the differentiation of CD209+ monocyte-derived dendritic cells and CD23+ myeloid dendritic cells through the action of allergen-specific CD4+ T cells.
[Journal of Experimental Medicine]
6445212 JKM53PBL items 1 apa default asc 1
A positive feedback loop reinforces the allergic immune response in human peanut allergy | Journal of Experimental Medicine | Rockefeller University Press. (n.d.). Retrieved May 5, 2021, from https://rupress.org/jem/article/218/7/e20201793/212046/A-positive-feedback-loop-reinforces-the-allergic Cite
Researchers characterized the constituent monocyte and lymphocyte populations between macaque species, and profile other major immune cell subsets including: CD4+ and CD8+ T cells, NK cells, B cells, monocyte subsets and myeloid dendritic cells.
6445212 BCJF4G4J items 1 apa default asc 1
Sibley, L., Daykin-Pont, O., Sarfas, C., Pascoe, J., White, A. D., & Sharpe, S. (2021). Differences in host immune populations between rhesus macaques and cynomolgus macaque subspecies in relation to susceptibility to Mycobacterium tuberculosis infection. Scientific Reports, 11(1), 8810. https://doi.org/10.1038/s41598-021-87872-x Cite
Scientists summarize the effects of TTP-mediated regulation of mRNA stability in dendritic cells (DCs), focusing on DC maturation and antigen presentation, T cell activation and differentiation, immune tolerance and inflammation.
6445212 KMVHXYRF items 1 apa default asc 1
Zhang, Y., Zhou, J., Wei, Z., Dong, H., Yang, D., Deng, Y., Li, J., Shi, S., Sun, Y., Lu, H., Yuan, J., Ni, B., Wu, Y., Tian, Y., & Han, C. (2021). TTP-mediated regulation of mRNA stability in immune cells contributes to adaptive immunity, immune tolerance and clinical applications. RNA Biology, 0(0), 1–7. https://doi.org/10.1080/15476286.2021.1917185 Cite
developed synthetic notch (synNotch)–CAR T cells targeting solid tumor antigens and used them to treat mouse models of mesothelioma, ovarian cancer, and glioblastoma.
[Science Translational Medicine]
7753456 C9VFE5SU items 1 apa default asc 1
Choe, J. H., Watchmaker, P. B., Simic, M. S., Gilbert, R. D., Li, A. W., Krasnow, N. A., Downey, K. M., Yu, W., Carrera, D. A., Celli, A., Cho, J., Briones, J. D., Duecker, J. M., Goretsky, Y. E., Dannenfelser, R., Cardarelli, L., Troyanskaya, O., Sidhu, S. S., Roybal, K. T., … Lim, W. A. (2021). SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma. Science Translational Medicine, 13(591). https://doi.org/10.1126/scitranslmed.abe7378 Cite
Investigators suggested that CD200 and CD276 were candidate inhibitory immune checkpoints in breast cancer stem cells, which were potentially regulated by Wnt, TGF‐β, and Hedgehog signaling.
DNA-methylation inhibitors have previously been shown to promote regulatory T cell responses and, in the present study, investigators evaluated their potential to ameliorate chronic and acute animal models of rheumatoid arthritis.
[Proceedings of the National Academy of Sciences of the United States of America]
6445212 LHQH2XFX items 1 apa default asc 1
Huang, Y.-S., Tseng, W.-Y., Clanchy, F. I. L., Topping, L. M., Ogbechi, J., McNamee, K., Perocheau, D., Chiang, N.-Y., Ericsson, P., Sundstedt, A., Xue, Z.-T., Salford, L. G., Sjögren, H.-O., Stone, T. W., Lin, H.-H., Luo, S.-F., & Williams, R. O. (2021). Pharmacological modulation of T cell immunity results in long-term remission of autoimmune arthritis. Proceedings of the National Academy of Sciences, 118(19). https://doi.org/10.1073/pnas.2100939118 Cite