Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Using a model of cutaneous allergen exposure, scientists showed that allergens directly activated TRPV1 + sensory neurons leading to itch and pain behaviors.
[Immunity]
Perner, C., Flayer, C. H., Zhu, X., Aderhold, P. A., Dewan, Z. N. A., Voisin, T., Camire, R. B., Chow, O. A., Chiu, I. M., & Sokol, C. L. (2020). Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.001 Cite
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Needle-Injectable Microcomposite Cryogel Scaffolds With Antimicrobial Properties

Researchers indicated that needle-injectable and biodegradable calcium peroxide-containing cryogels exhibited antimicrobial activity that holds great promise for a wide variety of biomedical applications, particularly when designing tissue engineering scaffolds.
[Scientific Reports]
Joshi Navare, K., Colombani, T., Rezaeeyazdi, M., Bassous, N., Rana, D., Webster, T., Memic, A., & Bencherif, S. A. (2020). Needle-injectable microcomposite cryogel scaffolds with antimicrobial properties. Scientific Reports, 10(1), 18370. https://doi.org/10.1038/s41598-020-75196-1 Cite
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Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Using a model of cutaneous allergen exposure, investigators showed that allergens directly activated TRPV1+ sensory neurons leading to itch and pain behaviors.
[Immunity]
Perner, C., Flayer, C. H., Zhu, X., Aderhold, P. A., Dewan, Z. N. A., Voisin, T., Camire, R. B., Chow, O. A., Chiu, I. M., & Sokol, C. L. (2020). Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2020.10.001 Cite
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Exosomal LGALS9 in the Cerebrospinal Fluid of Glioblastoma Patients Suppressed Dendritic Cell Antigen Presentation and Cytotoxic T-Cell Immunity

Researchers found that glioblastoma multiforme-cerebrospinal fluid-exosomes (GBM-CSF-Exos) contained a unique protein, LGALS9 ligand, which bound to the TIM3 receptor of dendritic cells (DCs) in the CSF to inhibit antigen recognition, processing and presentation by DCs, leading to failure of the cytotoxic T-cell-mediated antitumor immune response.
[Cell Death & Disease]
Wang, M., Cai, Y., Peng, Y., Xu, B., Hui, W., & Jiang, Y. (2020). Exosomal LGALS9 in the cerebrospinal fluid of glioblastoma patients suppressed dendritic cell antigen presentation and cytotoxic T-cell immunity. Cell Death & Disease, 11(10), 1–16. https://doi.org/10.1038/s41419-020-03042-3 Cite
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PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction

Emerging evidence indicates that the tumor microenvironment induces immune dysfunctional tumor-infiltrating DCs (TIDCs), characterized with both increased intracellular lipid content and mitochondrial respiration. Scientists report that fatty acid-carrying tumor-derived exosomes induce immune dysfunctional DCs to promote immune evasion.
[Cell Reports]
Yin, X., Zeng, W., Wu, B., Wang, L., Wang, Z., Tian, H., Wang, L., Jiang, Y., Clay, R., Wei, X., Qin, Y., Zhang, F., Zhang, C., Jin, L., & Liang, W. (2020). PPARα Inhibition Overcomes Tumor-Derived Exosomal Lipid-Induced Dendritic Cell Dysfunction. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108278 Cite
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Selective SIRPα Blockade Reverses Tumor T Cell Exclusion and Overcomes Cancer Immunotherapy Resistance

Scientists report a potent synergy between selective SIRPα blockade and immune checkpoint blockade in increasing memory T cell responses and reverting exclusion in syngeneic and orthotopic tumor models.
[Journal of Clinical Investigation]
Gauttier, V., Pengam, S., Durand, J., Biteau, K., Mary, C., Morello, A., Néel, M., Porto, G., Teppaz, G., Thepenier, V., Danger, R., Vince, N., Wilhelm, E., Girault, I., Abes, R., Ruiz, C., Trilleaud, C., Ralph, K.-L., Trombetta, E. S., … Poirier, N. (2020). Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI135528 Cite
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The Differential Immune Responses to COVID-19 in Peripheral and Lung Revealed by Single-Cell RNA Sequencing

Using single-cell RNA sequencing, researchers characterized the peripheral blood mononuclear cells from uninfected controls and COVID-19 patients and cells in paired broncho-alveolar lavage fluid.
[Cell Discovery]
The differential immune responses to COVID-19 in peripheral and lung revealed by single-cell RNA sequencing | Cell Discovery. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41421-020-00225-2 Cite
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Immunomodulatory Activity of IR700-Labelled Affibody Targeting HER2

Irradiating a co-culture of immature dendritic cells (DCs) and cancer cells exposed to light-activated ZHER2:2395-IR700 enhanced DC maturation, as indicated by augmented expression of CD86 and HLA-DR.
[Cell Death & Disease]
Immunomodulatory activity of IR700-labelled affibody targeting HER2 | Cell Death & Disease. (n.d.). Retrieved October 20, 2020, from https://www.nature.com/articles/s41419-020-03077-6 Cite
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New Treatment Addressing the Pathogenesis of Psoriasis

Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
[International Journal of Molecular Sciences]
Tokuyama, M., & Mabuchi, T. (2020). New Treatment Addressing the Pathogenesis of Psoriasis. International Journal of Molecular Sciences, 21(20), 7488. https://doi.org/10.3390/ijms21207488 Cite
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Expression of Leukotriene B4 Receptor 1 Defines Functionally Distinct DCs That Control Allergic Skin Inflammation

By generating Leukotriene B4 (LTB4)-producing enzyme LTA4H knockout mice and CD11c promoter-driven Cre recombinase-expressing BLT1 conditional knockout mice, researchers showed that the migration of BLT1hi dendritic cells exacerbated allergic contact dermatitis.
[Cellular & Molecular Immunology]
Koga, T., Sasaki, F., Saeki, K., Tsuchiya, S., Okuno, T., Ohba, M., Ichiki, T., Iwamoto, S., Uzawa, H., Kitajima, K., Meno, C., Nakamura, E., Tada, N., Fukui, Y., Kikuta, J., Ishii, M., Sugimoto, Y., Nakao, M., & Yokomizo, T. (2020). Expression of leukotriene B 4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Cellular & Molecular Immunology, 1–13. https://doi.org/10.1038/s41423-020-00559-7 Cite
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Landscape of Coordinated Immune Responses to H1N1 Challenge in Humans

Scientists showed changes in the abundance and activation states of more than 50 immune cell subsets in 35 individuals over 11 time points during human A/California/2009 (H1N1) virus challenge monitored using mass cytometry along with other clinical assessments.
[Journal of Clinical Investigation]
Rahil, Z., Leylek, R., Schürch, C. M., Chen, H., Bjornson-Hooper, Z., Christensen, S. R., Gherardini, P. F., Bhate, S. S., Spitzer, M. H., Fragiadakis, G. K., Mukherjee, N., Kim, N., Jiang, S., Yo, J., Gaudilliere, B., Affrime, M., Bock, B., Hensley, S. E., Idoyaga, J., … McIlwain, D. R. (2020). Landscape of coordinated immune responses to H1N1 challenge in humans. The Journal of Clinical Investigation, 130(11). https://doi.org/10.1172/JCI137265 Cite
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