PolyTLR7/8a-Conjugated, Antigen-Trapping Gold Nanorods Elicit Anticancer Immunity against Abscopal Tumors by Photothermal Therapy-Induced In Situ Vaccination

Scientists demonstrated that PTT-induced in situ vaccination cancer therapy can elicit potent antitumor immunity against disseminated and metastatic tumors.
[Biomaterials]
Liu, X., Su, Q., Song, H., Shi, X., Zhang, Y., Zhang, C., Huang, P., Dong, A., Kong, D., & Wang, W. (2021). PolyTLR7/8a-conjugated, antigen-trapping gold nanorods elicit anticancer immunity against abscopal tumors by photothermal therapy-induced in situ vaccination. Biomaterials, 275, 120921. https://doi.org/10.1016/j.biomaterials.2021.120921 Cite
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Integrin β7 Inhibits Colorectal Cancer Pathogenesis via Maintaining Anti-Tumor Immunity

Researchers found that the number of β7+ cells decreased significantly in tumor tissue compared with adjacent normal tissue. β7 expression decreased in tumor-derived compared to normal tissue-derived CD8+ T cells.
[Cancer Immunology Research]
Zhang, Y., Xie, R., Zhang, H., Zheng, Y., Lin, C., Yang, L., Huang, M., Li, M., Song, F., Lu, L., Yang, M., Liu, Y., Wei, Q., Li, J., & Chen, J. (2021). Integrin β7 inhibits colorectal cancer pathogenesis via maintaining anti-tumor immunity. Cancer Immunology Research. https://doi.org/10.1158/2326-6066.CIR-20-0879 Cite
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Single-Cell RNA Sequencing Identify SDCBP in ACE2-Positive Bronchial Epithelial Cells Negatively Correlates with COVID-19 Severity

Since angiotensin-converting enzyme 2 (ACE2)-positive cells were hosts for COVID-19, researchers focussed on this cell type to explore the underlying mechanisms of COVID-19.
[Journal of Cellular and Molecular Medicine]
Ma, D., Liu, S., Hu, L., He, Q., Shi, W., Yan, D., Cao, Y., Zhang, G., Wang, Z., Wu, J., & Jiang, C. (n.d.). Single-cell RNA sequencing identify SDCBP in ACE2-positive bronchial epithelial cells negatively correlates with COVID-19 severity. Journal of Cellular and Molecular Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1111/jcmm.16714 Cite
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Structural Specificities of Cell Surface β-Glucan Polysaccharides Determine Commensal Yeast Mediated Immuno-Modulatory Activities

MGCP, in contrast to previously identified microbial cell surface polysaccharides, through a Dectin1-Cox2 signaling axis in dendritic cells, facilitates regulatory T cell induction from naïve T cells.
[Nature Communications]
Lee, C., Verma, R., Byun, S., Jeun, E.-J., Kim, G.-C., Lee, S., Kang, H.-J., Kim, C. J., Sharma, G., Lahiri, A., Paul, S., Kim, K. S., Hwang, D. S., Iwakura, Y., Speciale, I., Molinaro, A., De Castro, C., Rudra, D., & Im, S.-H. (2021). Structural specificities of cell surface β-glucan polysaccharides determine commensal yeast mediated immuno-modulatory activities. Nature Communications, 12(1), 3611. https://doi.org/10.1038/s41467-021-23929-9 Cite
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Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
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Lentiviral Vector Induces High-Quality Memory T Cells via Dendritic Cells Transduction

With a mycobacterial immunogen, scientists observed distinct functional signatures and memory phenotype in lentiviral vector- or Adenovirus type 5-immunized mice, despite comparable antigen-specific CD8+ T cell magnitudes.
[Communications Biology]
Ku, M. W., Authié, P., Nevo, F., Souque, P., Bourgine, M., Romano, M., Charneau, P., & Majlessi, L. (2021). Lentiviral vector induces high-quality memory T cells via dendritic cells transduction. Communications Biology, 4(1), 1–16. https://doi.org/10.1038/s42003-021-02251-6 Cite
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Secreted Gelsolin Inhibits DNGR-1-Dependent Cross-Presentation and Cancer Immunity

Investigators showed that secreted gelsolin, an extracellular protein, decreased DNGR-1 binding to F-actin and cross-presentation of dead cell-associated antigens by type 1 conventional dendritic cells.
[Cell]
Giampazolias, E., Schulz, O., Lim, K. H. J., Rogers, N. C., Chakravarty, P., Srinivasan, N., Gordon, O., Cardoso, A., Buck, M. D., Poirier, E. Z., Canton, J., Zelenay, S., Sammicheli, S., Moncaut, N., Varsani-Brown, S., Rosewell, I., & Sousa, C. R. e. (2021). Secreted gelsolin inhibits DNGR-1-dependent cross-presentation and cancer immunity. Cell, 0(0). https://doi.org/10.1016/j.cell.2021.05.021 Cite
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Damon Runyon Cancer Research Foundation Announces 2021 Physician-Scientist Awardees

(Peter) Geon Kim, MD, with mentor Benjamin L. Ebert, MD, PhD, at the Dana-Farber Cancer Institute, was one of five recipients of the 2021 Damon Runyon Physician-Scientist Training Award. Dr. Kim’s research may provide insight into various inflammatory conditions associated with clonal hematopoiesis and potentially elucidate how clonal hematopoiesis progresses into blood cancer.
[Damon Runyon Cancer Research Foundation]
Press Release
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Non-Transplantable Cord Blood Units as a Source for Adoptive Immunotherapy of Leukemia and a Paradigm of Circular Economy in Medicine

Scientists explored the feasibility of generating bivalent-Leuk-STs directed against Wilms tumor 1 and preferentially expressed antigen in melanoma from umbilical cord blood units disqualified for allogeneic hematopoietic stem cell transplantation.
[British Journal of Haematology]
Koukoulias, K., Papadopoulou, A., Kouimtzidis, A., Papayanni, P.-G., Papaloizou, A., Sotiropoulos, D., Yiangou, M., Costeas, P., Anagnostopoulos, A., Yannaki, E., & Kaloyannidis, P. (n.d.). Non-transplantable cord blood units as a source for adoptive immunotherapy of leukaemia and a paradigm of circular economy in medicine. British Journal of Haematology, n/a(n/a). https://doi.org/https://doi.org/10.1111/bjh.17464 Cite
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Zbtb46-Dependent Altered Developmental Program in Embryonic Stem Cell-Derived Blood Cell Progenitors

Investigators probed the effect of the Zbtb46 transcription factor in ESC-derived blood cell progenitors using chemically inducible mouse cell lines.
[Stem Cells]
Boto, P., Gerzsenyi, T. B., Lengyel, A., Szunyog, B., & Szatmari, I. (n.d.). Zbtb46-dependent altered developmental program in embryonic stem cell-derived blood cell progenitors. STEM CELLS, n/a(n/a). https://doi.org/https://doi.org/10.1002/stem.3424 Cite
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Withaferin A Inhibits Lymphocyte Proliferation, Dendritic Cell Maturation In Vitro and Prolongs Islet Allograft Survival

The authors investigated the immunosuppressive and immunomodulation abilities of Withaferin A and its effect on long-term islet allograft survival.
[Scientific Reports]
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