Researchers summarize current knowledge of mouse and human conventional dendritic cells subsets and describe their hematopoietic development and their phenotypic and functional attributes.
[Annual Review of Immunology]
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Cabeza-Cabrerizo, M., Cardoso, A., Minutti, C. M., Costa, M. P. da, & Sousa, C. R. e. (2021, January 22). Dendritic Cells Revisited [Review-article]. Https://Doi.Org/10.1146/Annurev-Immunol-061020-053707. https://doi.org/10.1146/annurev-immunol-061020-053707 Cite
Scientists attempted to treat lung cancer using a personalized neoantigen peptide-pulsed autologous dendritic cell vaccine and conducted a single-arm, 2 medical centers, pilot study initiated by the investigator.
[Signal Transduction and Targeted Therapy]
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Ding, Z., Li, Q., Zhang, R., Xie, L., Shu, Y., Gao, S., Wang, P., Su, X., Qin, Y., Wang, Y., Fang, J., Zhu, Z., Xia, X., Wei, G., Wang, H., Qian, H., Guo, X., Gao, Z., Wang, Y., … Yang, L. (2021). Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer. Signal Transduction and Targeted Therapy, 6(1), 1–12. https://doi.org/10.1038/s41392-020-00448-5 Cite
Researchers demonstrated that altered dendritic cell representation in the skin-draining lymph nodes during sensitization to allergens caused Th2-driven contact hypersensitivity.
[Proceedings of the National Academy of Sciences of the United States of America]
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Miller, H. L., Andhey, P. S., Swiecki, M. K., Rosa, B. A., Zaitsev, K., Villani, A.-C., Mitreva, M., Artyomov, M. N., Gilfillan, S., Cella, M., & Colonna, M. (2021). Altered ratio of dendritic cell subsets in skin-draining lymph nodes promotes Th2-driven contact hypersensitivity. Proceedings of the National Academy of Sciences, 118(3). https://doi.org/10.1073/pnas.2021364118 Cite
Scientists showed that Mitomycin C (MMC) promoted immunogenic cell death (ICD) and in vivo tumor protection. MMC-induced ICD relied on metabolic reprogramming of tumor cells toward increased oxidative phosphorylation.
[Science Translational Medicine]
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Oresta, B., Pozzi, C., Braga, D., Hurle, R., Lazzeri, M., Colombo, P., Frego, N., Erreni, M., Faccani, C., Elefante, G., Barcella, M., Guazzoni, G., & Rescigno, M. (2021). Mitochondrial metabolic reprogramming controls the induction of immunogenic cell death and efficacy of chemotherapy in bladder cancer. Science Translational Medicine, 13(575). https://doi.org/10.1126/scitranslmed.aba6110 Cite
Deconvolution analysis revealed that the proportions of alveolar type 2 cells, proliferating basal cells, goblet cells, and proliferating natural killer/T cells decreased with age, whereas alveolar fibroblasts, pericytes, airway smooth muscle cells, endothelial cells and IGSF21+ dendritic cells increased with age.
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Scientists review the challenges and opportunities in using nanoparticles as a delivery mechanism to target dendritic cells and induce immunomodulation, emphasizing their versatility.
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Scientists found that conventional dendritic cells, defined in mice via expression of the transcription factor Zbtb46, were a major source of circulating sIL-6R and, thus, systemically regulated IL-6 signaling.
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The persistence of interleukin-6 is regulated by a blood buffer system derived from dendritic cells: Immunity. (n.d.). Retrieved January 5, 2021, from https://www.cell.com/immunity/fulltext/S1074-7613(20)30508-2 Cite
Overall HLA class I mismatch was also a significant risk factor and the predictor of post-cord blood transplantation viral infection, probably due to the insufficient cytotoxic T cell recognition and dendritic cell priming.
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Iemura, T., Arai, Y., Kanda, J., Kitawaki, T., Hishizawa, M., Kondo, T., Yamashita, K., & Takaori-Kondo, A. (2020). Impact of HLA class I allele-level mismatch on viral infection within 100 days after cord blood transplantation. Scientific Reports, 10(1), 21150. https://doi.org/10.1038/s41598-020-78259-5 Cite
Scientists showed that the Wnt family was extensively upregulated in and impacted the prognosis of patients with prostate adenocarcinoma and bladder urothelial carcinoma. Moreover, the Wnt family correlated with the levels of infiltrating immune cells, including B cells, CD4 + T cells, CD8 + T cells, neutrophils, macrophages, and dendritic cells.
[Cancer Gene Therapy]
Scientists showed that B7-CD28 co-stimulation and B7 expression by specific antigen-presenting cell types were required for clonal deletion and for regulatory T cell generation from endogenous tissue-restricted antigen-specific thymocytes.
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Scientists showed the prerequisite role of conventional dendritic cells in submandibular lymph nodes in the effectiveness of sublingual immunotherapy for the treatment of allergic disorders in mice.
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Miyanaga, N., Takagi, H., Uto, T., Fukaya, T., Nasu, J., Fukui, T., Nishikawa, Y., Sparwasser, T., Choijookhuu, N., Hishikawa, Y., Nakamura, T., Tono, T., & Sato, K. (2020). Essential role of submandibular lymph node dendritic cells in protective sublingual immunotherapy against murine allergy. Communications Biology, 3(1), 1–12. https://doi.org/10.1038/s42003-020-01466-3 Cite