Sialic Acid Blockade in Dendritic Cells Enhances CD8+ T Cell Responses by Facilitating High-Avidity Interactions

Scientists established cultures of murine bone marrow-derived dendritic cells that lacked sialic acid expression using a sialic acid-blocking mimetic Ac53FaxNeu5Ac.
[Cellular and Molecular Life Sciences]
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Integrative Bioinformatics and Experimental Analysis Revealed TEAD as Novel Prognostic Target for Hepatocellular Carcinoma and Its Roles in Ferroptosis Regulation

Investigators indicated that TEAD2/4 were significantly upregulated in HCC compared with normal tissues. Downregulation of TEAD2 promoted the death of HCC cells through inducing ferroptosis by iron accumulation and subsequent oxidative damage.
[Aging]
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CXCR3 Regulates Stem and Proliferative CD8+ T Cells during Chronic Infection by Promoting Interactions with DCs in Splenic Bridging Channels

The authors observed distinct locations for parasite-specific T cell subsets, implying a link between differentiation and anatomical niches in the spleen.
[Cell Reports]
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Exosome-Mediated Delivery of Transforming Growth Factor-β Receptor 1 Kinase Inhibitors and Toll-Like Receptor 7/8 Agonists for Combination Therapy of Tumors

Combination therapy with the transforming growth factor-β receptor I kinase inhibitor SD-208 and a toll-like receptor-7/8 agonist resiquimod was examined along with serum-derived exosomes as versatile carriers and may serve as a promising strategy to treat melanoma and prostate cancer.
[Acta Biomaterialia]
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The Idd2 Locus Confers Prominent Resistance to Autoimmune Diabetes

Researchers generated a NOD congenic mouse bearing B10 resistance alleles on chromosome 9 in a locus coinciding with part of the insulin-dependent diabetes (Idd) locus and found that NOD.
[Journal of Immunology]
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EBV+ Tumors Exploit Tumor Cell-Intrinsic and -Extrinsic Mechanisms to Produce Regulatory T Cell-Recruiting Chemokines CCL17 and CCL22

Both in vitro and in vivo Treg migration was effectively blocked by a novel, small molecule antagonist of CCR4, CCR4-351.
[PLoS Pathogens]
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Topical Astilbin Ameliorates Imiquimod-Induced Psoriasis-Like Skin Lesions in SKH-1 Mice via Suppression Dendritic Cell-Th17 Inflammation Axis

Investigators found that astilbin inhibited R837-induced maturation and activation of bone marrow-derived dendritic cells and decreased the expression of pro-inflammatory cytokines by downregulating myeloid differentiation factor 88.
[Journal of Cellular and Molecular Medicine]
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Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
[Frontiers in Immunology]
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Comprehensive Analysis of FKBP4/NR3C1/TMEM173 Signaling Pathway in Triple-Negative Breast Cancer Cell and Dendritic Cell among Tumor Microenvironment

The authors identified that FKBP4/NR3C1 axis was a novel negative regulator of TMEM173 in human breast cancer (BC) cells and demonstrated that FKBP4/NR3C1/TMEM173 signaling pathway could regulate autophagy and proliferation of BC cells as well as dendritic cell abundance through exosome release.
[Molecular Therapy Oncolytics]
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Phospholipase A2 Inhibitor and LY6/PLAUR Domain-Containing Protein PINLYP Regulates Type I Interferon Innate Immunity

Investigators characterized an unknown protein encoded by phospholipase A2 inhibitor and LY6/PLAUR domain-containing (PINLYP) gene that interacted with TBK1 and induced type I IFN in a TBK1- and IRF3-dependent manner.
[Proceedings of the National Academy of Sciences of the United States of America]
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A Multivariate Modeling Framework to Quantify Immune Checkpoint Context-Dependent Stimulation on T Cells

Researchers established an experimental system including a stimulus of interest, applied to an immune cell type in several contexts.
[Cell Discovery]
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