Tag Archives: dendritic cells

Human Anogenital Monocyte-Derived Dendritic Cells and langerin+cDC2 Are Major HIV Target Cells

Scientsts showed that HIV could penetrate the epithelial surface to interact with sub-epithelial resident mononuclear phagocytes in anogenital explants and defined the full array of subsets that were present in the human anogenital and colorectal tissues that HIV may encounter during sexual transmission.
[Nature Communications]
Rhodes, J. W., Botting, R. A., Bertram, K. M., Vine, E. E., Rana, H., Baharlou, H., Vegh, P., O’Neil, T. R., Ashhurst, A. S., Fletcher, J., Parnell, G. P., Graham, J. D., Nasr, N., Lim, J. J. K., Barnouti, L., Haertsch, P., Gosselink, M. P., Di Re, A., Reza, F., … Harman, A. N. (2021). Human anogenital monocyte-derived dendritic cells and langerin+cDC2 are major HIV target cells. Nature Communications, 12(1), 2147. https://doi.org/10.1038/s41467-021-22375-x Cite
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Control of IFN-I Responses by the Aminopeptidase IRAP in Neonatal C57BL/6 Alveolar Macrophages during RSV Infection

Neonatal C57BL/6 alveolar macrophages mobilized very weakly the IFN-I pathway upon Respiratory Syncytial Virus (RSV) infection in vitro and failed to restrain virus replication.
[Mucosal Immunology]
Drajac, C., Laubreton, D., Marquant, Q., Chottin, C., Ferret, C., Bouguyon, E., Schwartz-Cornil, I., Saveanu, L., Riffault, S., & Descamps, D. (2021). Control of IFN-I responses by the aminopeptidase IRAP in neonatal C57BL/6 alveolar macrophages during RSV infection. Mucosal Immunology, 1–14. https://doi.org/10.1038/s41385-021-00402-w Cite
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Calcineurin Inhibitors Suppress Acute Graft-vs-Host Disease via NFAT-Independent Inhibition of T Cell Receptor Signaling

Researchers utilized T cells from mice that express LckS59A, which cannot accept a phosphate at residue 59, to initiate acute graft-versus-host disease.
[Journal of Clinical Investigation]
Otsuka, S., Melis, N., Gaida, M. M., Dutta, D., Weigert, R., & Ashwell, J. D. (2021). Calcineurin inhibitors suppress acute graft-vs-host disease via NFAT-independent inhibition of T cell receptor signaling. The Journal of Clinical Investigation. https://doi.org/10.1172/JCI147683 Cite
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Improving Outcomes in Chronic Myeloid Leukemia through Harnessing the Immunological Landscape

Scientists focus on immune dysfunction in newly diagnosed chronic myeloid leukemia patients, and the role that tyrosine kinase inhibitors and other therapies have in restoring immune surveillance.
[Leukemia]
Hsieh, Y.-C., Kirschner, K., & Copland, M. (2021). Improving outcomes in chronic myeloid leukemia through harnessing the immunological landscape. Leukemia, 1–14. https://doi.org/10.1038/s41375-021-01238-w Cite
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Human Plasmacytoid Dendritic Cells Mount a Distinct Antiviral Response to Virus-Infected Cells

Human plasmacytoid dendritic cells produced high amounts of type I interferon when incubated with live cytomegalovirus-infected fibroblasts but not with free cytomegalovirus
[Science Immunology]
Yun, T. J., Igarashi, S., Zhao, H., Perez, O. A., Pereira, M. R., Zorn, E., Shen, Y., Goodrum, F., Rahman, A., Sims, P. A., Farber, D. L., & Reizis, B. (2021). Human plasmacytoid dendritic cells mount a distinct antiviral response to virus-infected cells. Science Immunology, 6(58). https://doi.org/10.1126/sciimmunol.abc7302 Cite
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Type 1 Conventional Dendritic Cell Fate and Function Are Controlled by DC-SCRIPT

Scientists showed that mice lacking dendritic cell (DC)-SCRIPT displayed substantially impaired development of IRF8–dependent conventional DC (cDC)1, whereas cDC2 numbers increased marginally.
[Science Immunology]
Zhang, S., Coughlan, H. D., Ashayeripanah, M., Seizova, S., Kueh, A. J., Brown, D. V., Cao, W., Jacquelot, N., D’Amico, A., Lew, A. M., Zhan, Y., Tonkin, C. J., Villadangos, J. A., Smyth, G. K., Chopin, M., & Nutt, S. L. (2021). Type 1 conventional dendritic cell fate and function are controlled by DC-SCRIPT. Science Immunology, 6(58). https://doi.org/10.1126/sciimmunol.abf4432 Cite
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Inositol 1,4, 5-Trisphosphate 3-Kinase B Promotes Ca2+ Mobilization and the Inflammatory Activity of Dendritic Cells

Researchers showed that the IP3 receptor 3 and ITPKB, a kinase that converts IP3 to inositol 1,3,4,5-tetrakisphosphate, were both necessary for Ca2+ mobilization and NFAT activation in mouse and human dendritic cells.
[Science Signaling]
Marongiu, L., Mingozzi, F., Cigni, C., Marzi, R., Gioia, M. D., Garrè, M., Parazzoli, D., Sironi, L., Collini, M., Sakaguchi, R., Morii, T., Crosti, M., Moro, M., Schurmans, S., Catelani, T., Rotem, R., Colombo, M., Shears, S., Prosperi, D., … Granucci, F. (2021). Inositol 1,4,5-trisphosphate 3-kinase B promotes Ca2+ mobilization and the inflammatory activity of dendritic cells. Science Signaling, 14(676). https://doi.org/10.1126/scisignal.aaz2120 Cite
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TAP Dysfunction in Dendritic Cells Enables Noncanonical Cross-Presentation for T Cell Priming

Scientists found that protective CD8+ T cells could be mobilized during viral infection even when TAP was absent in all hematopoietic cells.
[Nature Immunology]
Barbet, G., Nair-Gupta, P., Schotsaert, M., Yeung, S. T., Moretti, J., Seyffer, F., Metreveli, G., Gardner, T., Choi, A., Tortorella, D., Tampé, R., Khanna, K. M., García-Sastre, A., & Blander, J. M. (2021). TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nature Immunology, 1–13. https://doi.org/10.1038/s41590-021-00903-7 Cite
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Single-Cell Profiling of Myeloid Cells in Glioblastoma across Species and Disease Stage Reveals Macrophage Competition and Specialization

Scientists employed single-cell RNA sequencing and CITE-seq to map the glioblastoma immune landscape in mouse tumors and in patients with newly diagnosed disease or recurrence.
[Nature Neuroscience]
Pombo Antunes, A. R., Scheyltjens, I., Lodi, F., Messiaen, J., Antoranz, A., Duerinck, J., Kancheva, D., Martens, L., De Vlaminck, K., Van Hove, H., Kjølner Hansen, S. S., Bosisio, F. M., Van der Borght, K., De Vleeschouwer, S., Sciot, R., Bouwens, L., Verfaillie, M., Vandamme, N., Vandenbroucke, R. E., … Movahedi, K. (2021). Single-cell profiling of myeloid cells in glioblastoma across species and disease stage reveals macrophage competition and specialization. Nature Neuroscience, 1–16. https://doi.org/10.1038/s41593-020-00789-y Cite
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Fibroblast Activation Protein α-Targeted CD40 Agonism Abrogates Systemic Toxicity and Enables Administration of High Doses to Induce Effective Anti-tumor Immunity

Researchers developed a bispecific FAP-CD40 antibody, which induced CD40 stimulation solely in presence of fibroblast activation protein α (FAP), a protease specifically expressed in the tumor stroma.
[Clinical Cancer Research]
Sum, E., Rapp, M., Fröbel, P., Clech, M. L., Dürr, H., Giusti, A. M. F., Perro, M., Speziale, D., Kunz, L., Menietti, E., Brünker, P., Hopfer, U., Lechmann, M., Sobieniecki, A., Appelt, B., Adelfio, R., Nicolini, V. G., Freimoser-Grundschober, A., Jordaan, W. S., … Umana, P. (2021). Fibroblast activation protein α-targeted CD40 agonism abrogates systemic toxicity and enables administration of high doses to induce effective anti-tumor immunity. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4001 Cite
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BCL9/BCL9L Promotes Tumorigenicity through Immune-Dependent and Independent Mechanisms in Triple Negative Breast Cancer

Investigators demonstrated that the expression of BCL9 and BCL9L was directly correlated with malignancy in TNBC patient tumors and that BCL9 and BCL9L promoted tumor cell growth, cell migration and metastasis in TNBC models.
[Oncogene]
Wang, X., Feng, M., Xiao, T., Guo, B., Liu, D., Liu, C., Pei, J., Liu, Q., Xiao, Y., Rosin-Arbesfeld, R., Shi, Y., Zhou, Y., Yang, M., Feng, Y.-X., Jiang, Y., Shao, Z., Yu, K., & Zhu, D. (2021). BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01756-y Cite
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