Immune-Onc Therapeutics Announces First Patient Dosed in Phase 1 Clinical Trial Evaluating IO-108, a Novel Antagonist Antibody Targeting LILRB2 (ILT4), in Patients with Advanced Solid Tumors

Immune-Onc Therapeutics, Inc. announced that the first patient has been dosed in the company’s first-in-human clinical trial of IO-108, a novel antagonist antibody targeting the myeloid checkpoint Leukocyte Immunoglobulin-Like Receptor B2 (LILRB2) for the treatment of solid tumors.
[Immune-Onc Therapeutics, Inc.]
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Machine Learning Identification of Specific Changes in Myeloid Cell Phenotype during Bloodstream Infections

An eight-color antibody panel was used to identify seven monocyte and two dendritic cell subsets. In the learning cohort, immunophenotyping was applied to control subjects, postoperative heart surgery patients, as a model of noninfectious inflammatory responses, and blood culture-positive patients.
[Scientific Reports]
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The Cholesterol Metabolite 25-Hydroxycholesterol Restrains the Transcriptional Regulator SREBP2 and Limits Intestinal IgA Plasma Cell Differentiation

Researchers examined how the cholesterol metabolite 25-hydroxycholesterol impacted the intestinal B cell response. Mice lacking cholesterol 25-hydroxylase, the enzyme generating 25-HC, had higher frequencies of immunoglobulin A-secreting antigen-specific B cells upon immunization or infection.
[Immunity]
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Allogeneic Hematopoietic Cell Transplantation for Patients with Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Investigators reported on all 17 patients with BPDCN who underwent allogeneic hematopoietic cell transplantation (allo-HCT) at their center between 2000 and 2020, and concluded that allo-HCT provided long-lasting remissions in BPDCN patients, particularly when performed in complete remission.
[Bone Marrow Transplantation]
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Enhancing Adoptive CD8 T Cell Therapy by Systemic Delivery of Tumor Associated Antigens

Scientists showed that systemic delivery of tumor-associated antigens facilitated in vivo priming and expansion of previously non-activated T cells and enhanced the cytotoxicity of activated T cells.
[Scientific Reports]
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Inhibition of the BTK-IDO-mTOR Axis Promotes Differentiation of Monocyte-Lineage Dendritic Cells and Enhances Anti-Tumor T Cell Immunity

Researchers examined how targeting pathways that inhibit the differentiation of inflammatory myeloid cells affect antitumor immunity.
[Immunity]
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Anti-CD40 Antibodies Fused to CD40 Ligand Have Superagonist Properties

The authors showed that direct fusion of CD40L to certain agonistic anti-CD40 Abs conferred superagonist properties, reducing the dose required for efficacy, notably greatly increasing total cytokine secretion by human dendritic cells.
[Journal of Immunology]
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SEC61G Overexpression and DNA Amplification Correlates with Prognosis and Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma

SEC61G expression was analyzed using publicly available datasets. The association between SEC61G and disease prognosis was evaluated.
[Cancer Medicine]
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Blood and Immune Development in Human Fetal Bone Marrow and Down Syndrome

Hematopoietic progenitors from fetal liver, fetal bone marrow and cord blood exhibited transcriptional and functional differences that contributed to tissue-specific identity and cellular diversification.
[Nature]
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Distinct Single-Component Adjuvants Steer Human DC-Mediated T-cell Polarization via Toll-Like Receptor Signaling toward a Potent Antiviral Immune Response

Scientists assessed the effect of different adjuvants on human monocyte-derived dendritic cells and their ability to polarize innate and adaptive immune responses.
[Proceedings of the National Academy of Sciences of the United States of America]
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Novel Population of Human Monocyte and Osteoclast Progenitors from Pluripotent Stem Cells and Peripheral Blood

The authors developed reproducible methods to derive, from human pluripotent stem cells, a population containing monocyte progenitors able to generate functional osteoclast cells. Within this population, they identified cells with monocyte and osteoclast progenitor activity based on CD11b and CD14 expression.
[Blood Advances]
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